{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:11:29Z","timestamp":1792174289155,"version":"4.4.0"},"reference-count":125,"publisher":"Rockefeller University Press","issue":"1","license":[{"start":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T00:00:00Z","timestamp":1575504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.rupress.org\/terms\/"},{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"vor","delay-in-days":214,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1,6]]},"abstract":"<jats:p>Type III IFNs, or IFN-\u03bb, are the newest members of the IFN family and were long believed to play roles that were redundant with those of type I IFNs. However, IFN-\u03bb displays unique traits that delineate them as primary protectors of barrier integrity at mucosal sites. This unique role stems both from the restricted expression of IFN-\u03bb receptor, confined to epithelial cells and to a limited pool of immune cells, and from unique immunomodulatory properties of IFN-\u03bb. Here, we discuss recent findings that establish the unique capacity of IFN-\u03bb to act at the barriers of the host to balance tissue tolerance and immune resistance against viral and bacterial challenges.<\/jats:p>","DOI":"10.1084\/jem.20190295","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T17:44:17Z","timestamp":1575913457000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":158,"title":["Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion"],"prefix":"10.1084","volume":"217","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7244-2401","authenticated-orcid":true,"given":"Achille","family":"Broggi","sequence":"first","affiliation":[{"name":"Division of Immunology, Boston Children\u2019s Hospital and Harvard Medical School, Boston, MA 1"},{"name":"Division of Gastroenterology, Boston Children\u2019s Hospital and Harvard Medical School, Boston, MA 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7046-4914","authenticated-orcid":true,"given":"Francesca","family":"Granucci","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy 3"},{"name":"National Institute of Molecular Genetics \u201cRomeo ed Enrica Invernizzi\u201d, Milan, Italy 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3423-7474","authenticated-orcid":true,"given":"Ivan","family":"Zanoni","sequence":"additional","affiliation":[{"name":"Division of Immunology, Boston Children\u2019s Hospital and Harvard Medical School, Boston, MA 1"},{"name":"Division of Gastroenterology, Boston Children\u2019s Hospital and Harvard Medical School, Boston, MA 2"},{"name":"Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy 3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2019,12,5]]},"reference":[{"key":"2023072611080280700_bib1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.coi.2018.10.007","article-title":"Lambda interferons come to light: dual function cytokines mediating antiviral immunity and damage control","volume":"56","author":"Andreakos","year":"2019","journal-title":"Curr. 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