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Antibody responses are regulated by follicular helper T (TFH) cells and FOXP3+ follicular regulatory T (TFR) cells. Here we describe a subset of human tonsillar follicular T cells identified by expression of TFH markers and CD25 that are the main source of follicular T (TF) cell\u2013derived IL-10. Despite lack of FOXP3 expression, CD25+ TF cells resemble T reg cells in high CTLA4 expression, low IL-2 production, and their ability to repress T cell proliferation. CD25+ TF cell\u2013derived IL-10 dampens induction of B cell class-switching to IgE. In children, circulating total IgE titers were inversely correlated with the frequencies of tonsil CD25+ TF cells and IL-10\u2013producing TF cells but not with total T reg cells, TFR, or IL-10\u2013producing T cells. Thus, CD25+ TF cells emerge as a subset with unique T and B cell regulatory activities that may help prevent atopy.<\/jats:p>","DOI":"10.1084\/jem.20190493","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T08:27:47Z","timestamp":1560846467000},"page":"1843-1856","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":90,"title":["Regulatory roles of IL-10\u2013producing human follicular T cells"],"prefix":"10.1084","volume":"216","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6167-4186","authenticated-orcid":true,"given":"Pablo F.","family":"Ca\u00f1ete","sequence":"first","affiliation":[{"name":"Department of Immunology and Infectious Disease and Centre for Personalised Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca 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