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Moreover, in the absence of IL-18BP, excessive NK cell activation by IL-18 results in uncontrolled killing of human hepatocytes in vitro. Inherited human IL-18BP deficiency thus underlies fulminant HAV hepatitis by unleashing IL-18. These findings provide proof-of-principle that FVH can be caused by single-gene inborn errors that selectively disrupt liver-specific immunity. They also show that human IL-18 is toxic to the liver and that IL-18BP is its antidote.<\/jats:p>","DOI":"10.1084\/jem.20190669","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T14:35:15Z","timestamp":1560868515000},"page":"1777-1790","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":108,"title":["Inherited IL-18BP deficiency in human fulminant viral hepatitis"],"prefix":"10.1084","volume":"216","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4214-382X","authenticated-orcid":false,"given":"Serkan","family":"Belkaya","sequence":"first","affiliation":[{"name":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 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