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To address B cell tolerance and autoantibody formation to TG2, we generated immunoglobulin knock-in (Ig KI) mice that express a prototypical celiac patient\u2013derived anti-TG2 B cell receptor equally reactive to human and mouse TG2. We studied B cell development in the presence\/absence of autoantigen by crossing the Ig KI mice to Tgm2\u2212\/\u2212 mice. Autoreactive B cells in Tgm2+\/+ mice were indistinguishable from their naive counterparts in Tgm2\u2212\/\u2212 mice with no signs of clonal deletion, receptor editing, or B cell anergy. The autoreactive B cells appeared ignorant to their antigen, and they produced autoantibodies when provided T cell help. The findings lend credence to a model of celiac disease where gluten-reactive T cells provide help to autoreactive TG2-specific B cells by involvement of gluten\u2013TG2 complexes, and they outline a general mechanism of autoimmunity with autoantibodies being produced by ignorant B cells on provision of T cell help.<\/jats:p>","DOI":"10.1084\/jem.20190860","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T14:45:15Z","timestamp":1573742715000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":53,"title":["B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2"],"prefix":"10.1084","volume":"217","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9231-643X","authenticated-orcid":true,"given":"M. Fleur","family":"du Pr\u00e9","sequence":"first","affiliation":[{"name":"K.G. 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