{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:59:41Z","timestamp":1790755181592,"version":"4.1.0"},"reference-count":48,"publisher":"Rockefeller University Press","issue":"1","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.rupress.org\/terms\/"},{"start":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T00:00:00Z","timestamp":1625443200000},"content-version":"vor","delay-in-days":279,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81722045"],"award-info":[{"award-number":["81722045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673405"],"award-info":[{"award-number":["81673405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872844"],"award-info":[{"award-number":["81872844"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973302"],"award-info":[{"award-number":["81973302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LR17H310001"],"award-info":[{"award-number":["LR17H310001"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LY18H310003"],"award-info":[{"award-number":["LY18H310003"]}]},{"name":"Zhejiang Province","award":["ZJWR0108003"],"award-info":[{"award-number":["ZJWR0108003"]}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1,4]]},"abstract":"<jats:p>Neonatal hypoxic-ischemic encephalopathy (HIE) with the pathological characteristic of white matter injury often leads to lifelong cognitive and neurobehavioral dysfunction, but relevant therapies to promote remyelination are still unavailable. We found that histamine H2 receptor (H2R) negatively regulated the oligodendrocyte differentiation rate without affecting the oligodendrocytes at the oligodendrocyte precursor cell stage or mature stage following oxygen-glucose deprivation in vitro. Notably, selective deletion of the H2R gene (Hrh2) in differentiating oligodendrocytes (Hrh2fl\/fl;CNPase-Cre) improved their differentiation, remyelination, and functional recovery following neonatal hypoxia-ischemia in mice. The regulation of oligodendrocyte differentiation by H2R is mediated by binding with Axin2, which leads to up-regulation of the Wnt\/\u03b2-catenin signaling pathway. Furthermore, H2R antagonists also promoted oligodendrocyte differentiation and remyelination and the recovery of cognition and motor functions following neonatal hypoxia-ischemia. Thus, histamine H2R in oligodendrocytes could serve as a novel and effective therapeutic target for the retard of oligodendrocyte differentiation and remyelination following neonatal hypoxia-ischemia. The H2R antagonists may have potential therapeutic value for neonatal HIE.<\/jats:p>","DOI":"10.1084\/jem.20191365","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T14:04:30Z","timestamp":1601388270000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Histamine H2 receptor negatively regulates oligodendrocyte differentiation in neonatal hypoxic-ischemic white matter injury"],"prefix":"10.1084","volume":"218","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6481-1449","authenticated-orcid":true,"given":"Lei","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Department of Pharmacy of the Second Affiliated Hospital, National Health Commission and Chinese Academy of Medical Sciences Key Laboratory of Medical Neurobiology, Department of Anatomy, School of Basic Medical Science, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1286-9403","authenticated-orcid":true,"given":"Li","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Department of Pharmacy of the Second Affiliated Hospital, National Health Commission and Chinese Academy of Medical Sciences Key Laboratory of Medical Neurobiology, Department of Anatomy, School of Basic Medical Science, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0885-9947","authenticated-orcid":true,"given":"Han","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Department of Pharmacy of the Second Affiliated Hospital, National Health Commission and Chinese Academy of Medical Sciences Key Laboratory of Medical Neurobiology, Department of Anatomy, School of Basic Medical Science, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5768-2714","authenticated-orcid":true,"given":"Haibin","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Department of Pharmacy of the Second Affiliated Hospital, National Health Commission and Chinese Academy of Medical Sciences Key Laboratory of Medical Neurobiology, Department of Anatomy, School of Basic Medical Science, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1706-8901","authenticated-orcid":true,"given":"Dadao","family":"An","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Department of Pharmacy of the Second Affiliated Hospital, National Health Commission and Chinese Academy of Medical Sciences Key Laboratory of Medical Neurobiology, Department of Anatomy, School of Basic Medical Science, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5101-2923","authenticated-orcid":true,"given":"Qianyi","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Department of Pharmacy of the Second Affiliated Hospital, National Health Commission and Chinese Academy of Medical Sciences Key Laboratory of Medical Neurobiology, Department of Anatomy, School of Basic Medical Science, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6253-9835","authenticated-orcid":true,"given":"Yanrong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Department of Pharmacy of the Second Affiliated Hospital, National Health Commission and Chinese Academy of Medical Sciences Key Laboratory of Medical Neurobiology, Department of Anatomy, School of Basic Medical Science, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7603-7403","authenticated-orcid":true,"given":"Xiangnan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Department of Pharmacy of the Second Affiliated Hospital, National Health Commission and Chinese Academy of Medical Sciences Key Laboratory of Medical Neurobiology, Department of Anatomy, School of Basic Medical Science, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7768-6907","authenticated-orcid":true,"given":"Weiwei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Department of Pharmacy of the Second Affiliated Hospital, National Health Commission and Chinese Academy of Medical Sciences Key Laboratory of Medical Neurobiology, Department of Anatomy, School of Basic Medical Science, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4755-9357","authenticated-orcid":true,"given":"Zhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Department of Pharmacy of the Second Affiliated Hospital, National Health Commission and Chinese Academy of Medical Sciences Key Laboratory of Medical Neurobiology, Department of Anatomy, School of Basic Medical Science, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2020,9,29]]},"reference":[{"key":"2023072121182419300_bib1","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1523\/JNEUROSCI.22-02-00455.2002","article-title":"Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia","volume":"22","author":"Back","year":"2002","journal-title":"J. Neurosci"},{"key":"2023072121182419300_bib2","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1126\/science.280.5363.596","article-title":"Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta","volume":"280","author":"Behrens","year":"1998","journal-title":"Science"},{"key":"2023072121182419300_bib3","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/j.1750-3639.2007.00107.x","article-title":"Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia","volume":"18","author":"Billiards","year":"2008","journal-title":"Brain Pathol"},{"key":"2023072121182419300_bib4","first-page":"193","article-title":"Remyelination in experimental models of toxin-induced demyelination","volume-title":"Current Topics in Microbiology and Immunology.","author":"Blakemore","year":"2008"},{"key":"2023072121182419300_bib5","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1002\/ana.22627","article-title":"Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants","volume":"71","author":"Buser","year":"2012","journal-title":"Ann. Neurol"},{"key":"2023072121182419300_bib6","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1093\/brain\/awx312","article-title":"Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury","volume":"141","author":"Cree","year":"2018","journal-title":"Brain"},{"key":"2023072121182419300_bib7","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1111\/j.1471-4159.2005.03633.x","article-title":"Histamine protects against NMDA-induced necrosis in cultured cortical neurons through H receptor\/cyclic AMP\/protein kinase A and H receptor\/GABA release pathways","volume":"96","author":"Dai","year":"2006","journal-title":"J. Neurochem"},{"key":"2023072121182419300_bib8","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/nrneurol.2010.53","article-title":"Neurobiology of injury to the developing brain","volume":"6","author":"Deng","year":"2010","journal-title":"Nat. Rev. Neurol"},{"key":"2023072121182419300_bib9","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1001\/jamapediatrics.2014.3269","article-title":"Hypoxic-ischemic encephalopathy: a review for the clinician","volume":"169","author":"Douglas-Escobar","year":"2015","journal-title":"JAMA Pediatr"},{"key":"2023072121182419300_bib10","doi-asserted-by":"publisher","first-page":"E9685","DOI":"10.1073\/pnas.1714183114","article-title":"Thin myelin sheaths as the hallmark of remyelination persist over time and preserve axon function","volume":"114","author":"Duncan","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023072121182419300_bib11","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/nn.2855","article-title":"Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination","volume":"14","author":"Fancy","year":"2011","journal-title":"Nat. Neurosci"},{"key":"2023072121182419300_bib12","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nn.3676","article-title":"Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer","volume":"17","author":"Fancy","year":"2014","journal-title":"Nat. Neurosci"},{"key":"2023072121182419300_bib13","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/nrn2480","article-title":"Remyelination in the CNS: from biology to therapy","volume":"9","author":"Franklin","year":"2008","journal-title":"Nat. Rev. Neurosci"},{"key":"2023072121182419300_bib14","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020594","article-title":"Glia Disease and Repair-Remyelination","volume":"7","author":"Franklin","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol"},{"key":"2023072121182419300_bib15","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1152\/physrev.00043.2007","article-title":"Histamine in the nervous system","volume":"88","author":"Haas","year":"2008","journal-title":"Physiol. Rev"},{"key":"2023072121182419300_bib16","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/S0960-9822(98)70226-X","article-title":"Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta","volume":"8","author":"Hart","year":"1998","journal-title":"Curr. Biol"},{"key":"2023072121182419300_bib17","first-page":"253","article-title":"International Union of Pharmacology. XIII. Classification of histamine receptors","volume":"49","author":"Hill","year":"1997","journal-title":"Pharmacol. Rev"},{"key":"2023072121182419300_bib18","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.ejphar.2006.11.020","article-title":"Suppression of inflammatory cell recruitment by histamine receptor stimulation in ischemic rat brains","volume":"557","author":"Hiraga","year":"2007","journal-title":"Eur. J. Pharmacol"},{"key":"2023072121182419300_bib19","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.pharmthera.2017.02.039","article-title":"The roles of histamine and its receptor ligands in central nervous system disorders: An update","volume":"175","author":"Hu","year":"2017","journal-title":"Pharmacol. Ther"},{"key":"2023072121182419300_bib20","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3389\/neuro.05.005.2009","article-title":"Oligodendrocyte development and the onset of myelination in the human fetal brain","volume":"3","author":"Jakovcevski","year":"2009","journal-title":"Front. Neuroanat"},{"key":"2023072121182419300_bib21","doi-asserted-by":"publisher","first-page":"F153","DOI":"10.1136\/adc.2006.108837","article-title":"Pathogenesis of cerebral white matter injury of prematurity","volume":"93","author":"Khwaja","year":"2008","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed"},{"key":"2023072121182419300_bib22","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.earlhumdev.2010.05.010","article-title":"Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy","volume":"86","author":"Kurinczuk","year":"2010","journal-title":"Early Hum. Dev"},{"key":"2023072121182419300_bib23","doi-asserted-by":"publisher","first-page":"15356","DOI":"10.1038\/srep15356","article-title":"Histidine provides long-term neuroprotection after cerebral ischemia through promoting astrocyte migration","volume":"5","author":"Liao","year":"2015","journal-title":"Sci. Rep"},{"key":"2023072121182419300_bib24","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.jneumeth.2018.05.024","article-title":"A stable and easily reproducible model of focal white matter demyelination","volume":"307","author":"Luo","year":"2018","journal-title":"J. Neurosci. Methods"},{"key":"2023072121182419300_bib25","doi-asserted-by":"publisher","first-page":"12079","DOI":"10.1038\/srep12079","article-title":"Early treatment of minocycline alleviates white matter and cognitive impairments after chronic cerebral hypoperfusion","volume":"5","author":"Ma","year":"2015","journal-title":"Sci. Rep"},{"key":"2023072121182419300_bib26","doi-asserted-by":"publisher","first-page":"7925","DOI":"10.1523\/JNEUROSCI.1493-16.2016","article-title":"Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination","volume":"36","author":"Mei","year":"2016","journal-title":"J. Neurosci"},{"key":"2023072121182419300_bib27","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.bbr.2006.05.007","article-title":"Behavioral effects of corpus callosum transection and environmental enrichment in adult rats","volume":"172","author":"Miu","year":"2006","journal-title":"Behav. Brain Res"},{"key":"2023072121182419300_bib28","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1111\/j.1471-4159.2008.05424.x","article-title":"Histamine induces neural stem cell proliferation and neuronal differentiation by activation of distinct histamine receptors","volume":"106","author":"Molina-Hern\u00e1ndez","year":"2008","journal-title":"J. Neurochem"},{"key":"2023072121182419300_bib29","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/j.bcp.2005.12.037","article-title":"Histamine H2 receptor overexpression induces U937 cell differentiation despite triggered mechanisms to attenuate cAMP signalling","volume":"71","author":"Monczor","year":"2006","journal-title":"Biochem. Pharmacol"},{"key":"2023072121182419300_bib30","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/nrn3526","article-title":"The histaminergic network in the brain: basic organization and role in disease","volume":"14","author":"Panula","year":"2013","journal-title":"Nat. Rev. Neurosci"},{"key":"2023072121182419300_bib31","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3389\/fnsys.2014.00064","article-title":"Histamine in the brain","volume":"8","author":"Passani","year":"2014","journal-title":"Front. Syst. Neurosci"},{"key":"2023072121182419300_bib32","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1242\/dev.018234","article-title":"Netrin 1 and Dcc regulate oligodendrocyte process branching and membrane extension via Fyn and RhoA","volume":"136","author":"Rajasekharan","year":"2009","journal-title":"Development"},{"key":"2023072121182419300_bib33","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1002\/ana.21359","article-title":"Arrested oligodendrocyte lineage maturation in chronic perinatal white matter injury","volume":"63","author":"Segovia","year":"2008","journal-title":"Ann. Neurol"},{"key":"2023072121182419300_bib34","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s12264-018-0207-9","article-title":"Myt1L Promotes Differentiation of Oligodendrocyte Precursor Cells and is Necessary for Remyelination After Lysolecithin-Induced Demyelination","volume":"34","author":"Shi","year":"2018","journal-title":"Neurosci. Bull"},{"key":"2023072121182419300_bib35","first-page":"437","article-title":"H1-antihistamines in children","volume":"17","author":"Simons","year":"2002","journal-title":"Clin. Allergy Immunol"},{"key":"2023072121182419300_bib36","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1097\/WOX.0b013e318186fb3a","article-title":"H1 antihistamines: current status and future directions","volume":"1","author":"Simons","year":"2008","journal-title":"World Allergy Organ. J"},{"key":"2023072121182419300_bib37","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0736-5748(00)00075-7","article-title":"Hypoxic-ischemic injury results in acute disruption of myelin gene expression and death of oligodendroglial precursors in neonatal mice","volume":"19","author":"Skoff","year":"2001","journal-title":"Int. J. Dev. Neurosci"},{"key":"2023072121182419300_bib38","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jpeds.2016.03.059","article-title":"Neonatal Histamine-2 Receptor Antagonist and Proton Pump Inhibitor Treatment at United States Children\u2019s Hospitals","volume":"174","author":"Slaughter","year":"2016","journal-title":"J. Pediatr"},{"key":"2023072121182419300_bib39","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1111\/j.1471-4159.1992.tb08903.x","article-title":"Pharmacological characterization and autoradiographic localization of histamine H2 receptors in human brain identified with [125I]iodoaminopotentidine","volume":"59","author":"Traiffort","year":"1992","journal-title":"J. Neurochem"},{"key":"2023072121182419300_bib40","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.neuron.2018.07.017","article-title":"Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia","volume":"99","author":"Wang","year":"2018","journal-title":"Neuron"},{"key":"2023072121182419300_bib41","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.pep.2010.04.009","article-title":"The tandem affinity purification method: an efficient system for protein complex purification and protein interaction identification","volume":"72","author":"Xu","year":"2010","journal-title":"Protein Expr. Purif"},{"key":"2023072121182419300_bib42","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.jneumeth.2005.05.003","article-title":"Optimization of oligodendrocyte progenitor cell culture method for enhanced survival","volume":"149","author":"Yang","year":"2005","journal-title":"J. Neurosci. Methods"},{"key":"2023072121182419300_bib43","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/nn.2333","article-title":"HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction","volume":"12","author":"Ye","year":"2009","journal-title":"Nat. Neurosci"},{"key":"2023072121182419300_bib44","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1080\/14737175.2017.1259567","article-title":"Neonatal hypoxic ischemic encephalopathy: an update on disease pathogenesis and treatment","volume":"17","author":"Y\u0131ld\u0131z","year":"2017","journal-title":"Expert Rev. Neurother"},{"key":"2023072121182419300_bib45","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1080\/15548627.2017.1357792","article-title":"BNIP3L\/NIX-mediated mitophagy protects against ischemic brain injury independent of PARK2","volume":"13","author":"Yuan","year":"2017","journal-title":"Autophagy"},{"key":"2023072121182419300_bib46","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1111\/cns.12379","article-title":"Histamine promotes locomotion recovery after spinal cord hemisection via inhibiting astrocytic scar formation","volume":"21","author":"Zhao","year":"2015","journal-title":"CNS Neurosci. Ther"},{"key":"2023072121182419300_bib47","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s12035-014-8678-9","article-title":"GSK3\u03b2 promotes the differentiation of oligodendrocyte precursor cells via \u03b2-catenin-mediated transcriptional regulation","volume":"50","author":"Zhou","year":"2014","journal-title":"Mol. Neurobiol"},{"key":"2023072121182419300_bib48","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.bbi.2016.09.024","article-title":"Interleukin-1\u03b2 impedes oligodendrocyte progenitor cell recruitment and white matter repair following chronic cerebral hypoperfusion","volume":"60","author":"Zhou","year":"2017","journal-title":"Brain Behav. Immun"}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20191365\/1455813\/jem_20191365.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20191365\/1455813\/jem_20191365.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T21:21:32Z","timestamp":1689974492000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/218\/1\/e20191365\/152128\/Histamine-H2-receptor-negatively-regulates"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,29]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1,4]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20191365","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,29]]},"article-number":"e20191365"}}