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Its pivotal role in antifungal defense and its central position in the pathogenesis of inflammatory diseases including psoriasis were discovered only relatively late in the early 2000s. Since the connection of dysregulated IL-17 and psoriasis pathogenesis turned out to be particularly evident, a number of monoclonal antibodies targeting IL-17 pathways have been approved and are used as first line treatment of moderate-to-severe plaque psoriasis and psoriatic arthritis, and further agents are currently in clinical development.<\/jats:p>","DOI":"10.1084\/jem.20191397","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T14:44:13Z","timestamp":1573742653000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":77,"title":["Interleukin-17 cytokines: Effectors and targets in psoriasis\u2014A breakthrough in understanding and treatment"],"prefix":"10.1084","volume":"217","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8789-9578","authenticated-orcid":true,"given":"Immo","family":"Prinz","sequence":"first","affiliation":[{"name":"Institute of Immunology, Hannover Medical School, Hannover, Germany 1"},{"name":"Centre for Individualized Infection Medicine, Hannover, Germany 2"},{"name":"Cluster of Excellence RESIST - Resolving Infection Susceptibility (EXC 2155), Hannover Medical School, Hannover, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Sandrock","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School, Hannover, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Mrowietz","sequence":"additional","affiliation":[{"name":"Psoriasis Center at the Department of Dermatology and Comprehensive Center for Inflammation Medicine, University Medical Center Schleswig-Holstein, Campus Kiel, Germany 4"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"2023072617502000900_bib1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aat4617","article-title":"IL-17 integrates multiple self-reinforcing, feed-forward mechanisms through the RNA binding protein Arid5a","volume":"11","author":"Amatya","year":"2018","journal-title":"Sci. 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