{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:47:03Z","timestamp":1791920823193,"version":"4.3.4"},"reference-count":62,"publisher":"Rockefeller University Press","issue":"2","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.rupress.org\/terms\/"},{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":265,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008672","name":"Wilhelm Sander Stiftung","doi-asserted-by":"publisher","award":["1 027 087 401"],"award-info":[{"award-number":["1 027 087 401"]}],"id":[{"id":"10.13039\/100008672","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"publisher","award":["BMBF 01 EO 0803"],"award-info":[{"award-number":["BMBF 01 EO 0803"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"publisher","award":["BMBF 01GM1111B"],"award-info":[{"award-number":["BMBF 01GM1111B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CoNfirm","award":["FKZ 01ZX1708F"],"award-info":[{"award-number":["FKZ 01ZX1708F"]}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["VO 1835\/3-1"],"award-info":[{"award-number":["VO 1835\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["MA1351\/12-1"],"award-info":[{"award-number":["MA1351\/12-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002714","name":"University of Freiburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002714","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Else\u2013Kr\u00f6ner\u2013Fresenius\u2013Stiftung"},{"name":"Berta-Ottenstein-Program for Clinician Scientists"}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:p>The identification and characterization of rare immune cell populations in humans can be facilitated by their growth advantage in the context of specific genetic diseases. Here, we use autoimmune lymphoproliferative syndrome to identify a population of FAS-controlled TCR\u03b1\u03b2+ T cells. They include CD4+, CD8+, and double-negative T cells and can be defined by a CD38+CD45RA+T-BET\u2212 expression pattern. These unconventional T cells are present in healthy individuals, are generated before birth, are enriched in lymphoid tissue, and do not expand during acute viral infection. They are characterized by a unique molecular signature that is unambiguously different from other known T cell differentiation subsets and independent of CD4 or CD8 expression. Functionally, FAS-controlled T cells represent highly proliferative, noncytotoxic T cells with an IL-10 cytokine bias. Mechanistically, regulation of this physiological population is mediated by FAS and CTLA4 signaling, and its survival is enhanced by mTOR and STAT3 signals. Genetic alterations in these pathways result in expansion of FAS-controlled T cells, which can cause significant lymphoproliferative disease.<\/jats:p>","DOI":"10.1084\/jem.20192191","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T14:26:50Z","timestamp":1605018410000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS"],"prefix":"10.1084","volume":"218","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6488-7622","authenticated-orcid":true,"given":"Maria Elena","family":"Maccari","sequence":"first","affiliation":[{"name":"Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 1"},{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9191-7970","authenticated-orcid":true,"given":"Sebastian","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development, Immunology, Infectious Diseases and Ophthalmology (I2O) Discovery and Translational Area, Roche Innovation Center Basel, Basel, Switzerland 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6876-2875","authenticated-orcid":true,"given":"Patrick","family":"Kury","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 1"},{"name":"Faculty of Biology, University of Freiburg, Freiburg, Germany 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5389-9481","authenticated-orcid":true,"given":"Geoffroy","family":"Andrieux","sequence":"additional","affiliation":[{"name":"Institute of Medical Bioinformatics and Systems Medicine, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 5"},{"name":"German Cancer Consortium, Freiburg, and German Cancer Research Center, Heidelberg, Germany 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2193-3048","authenticated-orcid":true,"given":"Simon","family":"V\u00f6lkl","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 5\u2013Hematology\/Oncology, University of Erlangen, Erlangen, Germany 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2552-740X","authenticated-orcid":true,"given":"Bertram","family":"Bengsch","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 8"},{"name":"Center for Integrative Biological Signaling Studies, Albert-Ludwigs University, Freiburg, Germany 9"},{"name":"Bioss Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany 10"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-4550","authenticated-orcid":true,"given":"Myriam Ricarda","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine, University of Ulm, Ulm, Germany 11"},{"name":"Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service Baden-Wuerttemberg\u2013Hessen, Ulm, Germany 12"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9594-1377","authenticated-orcid":true,"given":"Maximilian","family":"Heeg","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 1"},{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0390-406X","authenticated-orcid":true,"given":"Jan","family":"Rohr","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 1"},{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6370-4919","authenticated-orcid":true,"given":"Sabine","family":"J\u00e4gle","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2689-9072","authenticated-orcid":true,"given":"Carla N.","family":"Castro","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8630-5275","authenticated-orcid":true,"given":"Miriam","family":"Gro\u00df","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 1"},{"name":"Faculty of Biology, University of Freiburg, Freiburg, Germany 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Warthorst","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0256-0680","authenticated-orcid":true,"given":"Christoph","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 1"},{"name":"Faculty of Biology, University of Freiburg, Freiburg, Germany 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1146-7250","authenticated-orcid":true,"given":"Ilka","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6217-1556","authenticated-orcid":true,"given":"Carsten","family":"Speckmann","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 1"},{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0226-1955","authenticated-orcid":true,"given":"Julian","family":"Thalhammer","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 1"},{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2729-6177","authenticated-orcid":true,"given":"Friedrich G.","family":"Kapp","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0981-8661","authenticated-orcid":true,"given":"Markus G.","family":"Seidel","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology-Oncology, Department of Pediatrics and Adolescent Medicine, Medical University Graz, Graz, Austria 13"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2220-6010","authenticated-orcid":true,"given":"Gregor","family":"D\u00fcckers","sequence":"additional","affiliation":[{"name":"Helios Kliniken Krefeld, Children\u2019s Hospital, Krefeld, Germany 14"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7222-296X","authenticated-orcid":true,"given":"Stefan","family":"Sch\u00f6nberger","sequence":"additional","affiliation":[{"name":"University of Bonn, Department of Paediatric Haematology and Oncology, University Children's Hospital Bonn, Germany 15"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8731-8924","authenticated-orcid":true,"given":"Catharina","family":"Sch\u00fctz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany 16"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3423-0854","authenticated-orcid":true,"given":"Marita","family":"F\u00fchrer","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine, University of Ulm, Ulm, Germany 11"},{"name":"Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service Baden-Wuerttemberg\u2013Hessen, Ulm, Germany 12"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6067-3408","authenticated-orcid":true,"given":"Robin","family":"Kobbe","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Division of Infectious Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany 17"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8062-8820","authenticated-orcid":true,"given":"Dirk","family":"Holzinger","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology-Oncology, University of Duisburg-Essen, Essen, Germany 18"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5639-8690","authenticated-orcid":true,"given":"Christian","family":"Klemann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany 19"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3158-7484","authenticated-orcid":true,"given":"Petr","family":"Smisek","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, University Hospital Motol and Second Faculty of Medicine, Charles University, Prague, Czech Republic 20"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6979-9207","authenticated-orcid":true,"given":"Stephen","family":"Owens","sequence":"additional","affiliation":[{"name":"Great North Children\u2019s Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK 21"},{"name":"Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK 22"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5491-7832","authenticated-orcid":true,"given":"Gerd","family":"Horneff","sequence":"additional","affiliation":[{"name":"Department of General Paediatrics, Clinic Sankt Augustin, Sankt Augustin, Germany 23"},{"name":"Department of Pediatric and Adolescent Medicine, University Hospital of Cologne, Cologne, Germany 24"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7689-9786","authenticated-orcid":true,"given":"Reinhard","family":"Kolb","sequence":"additional","affiliation":[{"name":"Department of General Paediatrics, Clinic Oldenburg, Oldenburg, Germany 25"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5606-9822","authenticated-orcid":true,"given":"Nora","family":"Naumann-Bartsch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Erlangen, Germany 26"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-1704","authenticated-orcid":true,"given":"Maurizio","family":"Miano","sequence":"additional","affiliation":[{"name":"Haematology Unit, Istituto di Ricovero e Cura a Carattere Scientifico Istituto Giannina Gaslini, Genoa, Italy 27"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4050-2772","authenticated-orcid":true,"given":"Julian","family":"Staniek","sequence":"additional","affiliation":[{"name":"Faculty of Biology, University of Freiburg, Freiburg, Germany 4"},{"name":"Department of Rheumatology and Clinical Immunology, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 28"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5153-6089","authenticated-orcid":true,"given":"Marta","family":"Rizzi","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 1"},{"name":"Department of Rheumatology and Clinical Immunology, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 28"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4475-2872","authenticated-orcid":true,"given":"Tomas","family":"Kalina","sequence":"additional","affiliation":[{"name":"Childhood Leukemia Investigation Prague, Department of Pediatric Hematology and Oncology, Second Medical School, Charles University and University Hospital Motol, Prague, Czech Republic 29"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0677-9409","authenticated-orcid":true,"given":"Pascal","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Lausanne, Epalinges, Switzerland 30"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-6478","authenticated-orcid":true,"given":"Anika","family":"Erxleben","sequence":"additional","affiliation":[{"name":"Bioinformatics, Institute for Computer Science, Faculty of Engineering, University of Freiburg, Germany 31"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8231-3323","authenticated-orcid":true,"given":"Rolf","family":"Backofen","sequence":"additional","affiliation":[{"name":"Bioinformatics, Institute for Computer Science, Faculty of Engineering, University of Freiburg, Germany 31"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6099-7066","authenticated-orcid":true,"given":"Arif","family":"Ekici","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, University of Erlangen, Erlangen, Germany 32"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3856-7937","authenticated-orcid":true,"given":"Charlotte M.","family":"Niemeyer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1172-865X","authenticated-orcid":true,"given":"Klaus","family":"Warnatz","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6897-6806","authenticated-orcid":true,"given":"Bodo","family":"Grimbacher","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 1"},{"name":"Center for Integrative Biological Signaling Studies, Albert-Ludwigs University, Freiburg, Germany 9"},{"name":"German Center for Infection Research, Satellite Center, Freiburg, Germany 33"},{"name":"Resolving Infection Susceptibility Cluster of Excellence 2155, Hanover Medical School, Satellite Center, Freiburg, Germany 34"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2901-2809","authenticated-orcid":true,"given":"Hermann","family":"Eibel","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0685-4483","authenticated-orcid":true,"given":"Andreas","family":"Mackensen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 5\u2013Hematology\/Oncology, University of Erlangen, Erlangen, Germany 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9996-8251","authenticated-orcid":true,"given":"Andreas Philipp","family":"Frei","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development, Immunology, Infectious Diseases and Ophthalmology (I2O) Discovery and Translational Area, Roche Innovation Center Basel, Basel, Switzerland 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine, University of Ulm, Ulm, Germany 11"},{"name":"Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service Baden-Wuerttemberg\u2013Hessen, Ulm, Germany 12"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3670-0602","authenticated-orcid":true,"given":"Melanie","family":"Boerries","sequence":"additional","affiliation":[{"name":"Institute of Medical Bioinformatics and Systems Medicine, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 5"},{"name":"German Cancer Consortium, Freiburg, and German Cancer Research Center, Heidelberg, Germany 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9265-2721","authenticated-orcid":true,"given":"Stephan","family":"Ehl","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 1"},{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 2"},{"name":"Center for Integrative Biological Signaling Studies, Albert-Ludwigs University, Freiburg, Germany 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7031-0018","authenticated-orcid":true,"given":"Anne","family":"Rensing-Ehl","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"2023072611212395300_bib1","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/nbt.2594","article-title":"viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia","volume":"31","author":"Amir","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"2023072611212395300_bib2","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1002\/cyto.a.20643","article-title":"Phenotype and function of human T lymphocyte subsets: consensus and issues","volume":"73","author":"Appay","year":"2008","journal-title":"Cytometry A."},{"key":"2023072611212395300_bib3","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/nbt.4314","article-title":"Dimensionality reduction for visualizing single-cell data using UMAP","volume":"37","author":"Becht","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"2023072611212395300_bib4","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.clim.2017.12.009","article-title":"Pediatric-onset Evans syndrome: Heterogeneous presentation and high frequency of monogenic disorders including LRBA and CTLA4 mutations","volume":"188","author":"Besnard","year":"2018","journal-title":"Clin. Immunol."},{"key":"2023072611212395300_bib5","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1006\/clim.2001.5069","article-title":"TcR-alpha\/beta(+) CD4(-)CD8(-) T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis","volume":"100","author":"Bleesing","year":"2001","journal-title":"Clin. Immunol."},{"key":"2023072611212395300_bib6","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1006\/clim.2002.5225","article-title":"A composite picture of TcR alpha\/beta(+) CD4(-)CD8(-) T Cells (alpha\/beta-DNTCs) in humans with autoimmune lymphoproliferative syndrome","volume":"104","author":"Bleesing","year":"2002","journal-title":"Clin. Immunol."},{"key":"2023072611212395300_bib7","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1182\/blood-2002-07-2103","article-title":"Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells","volume":"101","author":"Brenchley","year":"2003","journal-title":"Blood."},{"key":"2023072611212395300_bib8","doi-asserted-by":"publisher","first-page":"440","DOI":"10.4049\/jimmunol.181.1.440","article-title":"Human TCR alpha\/beta+ CD4-CD8- double-negative T cells in patients with autoimmune lymphoproliferative syndrome express restricted Vbeta TCR diversity and are clonally related to CD8+ T cells","volume":"181","author":"Bristeau-Leprince","year":"2008","journal-title":"J. Immunol."},{"key":"2023072611212395300_bib9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1006368","article-title":"Quantitative single cell analysis uncovers the life\/death decision in CD95 network","volume":"14","author":"Buchbinder","year":"2018","journal-title":"PLOS Comput. Biol."},{"key":"2023072611212395300_bib10","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.immuni.2015.04.010","article-title":"FAS inactivation releases unconventional germinal center B cells that escape antigen control and drive IgE and autoantibody production","volume":"42","author":"Butt","year":"2015","journal-title":"Immunity."},{"key":"2023072611212395300_bib11","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics."},{"key":"2023072611212395300_bib12","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.4049\/jimmunol.156.7.2357","article-title":"Different susceptibility of cytotoxic T cells to CD95 (Fas\/Apo-1) ligand-mediated cell death after activation in vitro versus in vivo","volume":"156","author":"Ehl","year":"1996","journal-title":"J. Immunol."},{"key":"2023072611212395300_bib13","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2016.1256526","article-title":"FAM13A is associated with non-small cell lung cancer (NSCLC) progression and controls tumor cell proliferation and survival","volume":"6","author":"Eisenhut","year":"2016","journal-title":"OncoImmunology."},{"key":"2023072611212395300_bib14","doi-asserted-by":"publisher","first-page":"2828","DOI":"10.1182\/blood-2004-07-2583","article-title":"Isolation and characterization of human antigen-specific TCR alpha beta+ CD4(-)CD8- double-negative regulatory T cells","volume":"105","author":"Fischer","year":"2005","journal-title":"Blood."},{"key":"2023072611212395300_bib15","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/0092-8674(95)90013-6","article-title":"Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome","volume":"81","author":"Fisher","year":"1995","journal-title":"Cell."},{"key":"2023072611212395300_bib16","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1093\/intimm\/dxq466","article-title":"Fas (CD95\/APO-1) limits the expansion of T lymphocytes in an environment of limited T-cell antigen receptor\/MHC contacts","volume":"23","author":"Fortner","year":"2011","journal-title":"Int. Immunol."},{"key":"2023072611212395300_bib17","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1002\/eji.201847862","article-title":"High-dimensional single-cell proteomics analysis identifies immune checkpoint signatures and therapeutic targets in ulcerative colitis","volume":"49","author":"Fuchs","year":"2019","journal-title":"Eur. J. Immunol."},{"key":"2023072611212395300_bib18","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1007\/s10495-015-1104-6","article-title":"Lipid rafts and raft-mediated supramolecular entities in the regulation of CD95 death receptor apoptotic signaling","volume":"20","author":"Gajate","year":"2015","journal-title":"Apoptosis."},{"key":"2023072611212395300_bib19","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/s41590-018-0311-z","article-title":"The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity","volume":"20","author":"Gautam","year":"2019","journal-title":"Nat. Immunol."},{"key":"2023072611212395300_bib20","doi-asserted-by":"publisher","first-page":"26389","DOI":"10.1074\/jbc.271.42.26389","article-title":"Fas-induced apoptosis is mediated by activation of a Ras and Rac protein-regulated signaling pathway","volume":"271","author":"Gulbins","year":"1996","journal-title":"J. Biol. Chem."},{"key":"2023072611212395300_bib21","doi-asserted-by":"publisher","first-page":"883","DOI":"10.3389\/fimmu.2019.00883","article-title":"Human double-negative regulatory T-cells induce a metabolic and functional switch in effector T-cells by suppressing mTOR activity","volume":"10","author":"Haug","year":"2019","journal-title":"Front. Immunol."},{"key":"2023072611212395300_bib22","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1128\/MCB.23.4.1428-1440.2003","article-title":"Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex","volume":"23","author":"Holler","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"2023072611212395300_bib23","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1056\/NEJMoa040036","article-title":"Autoimmune lymphoproliferative syndrome with somatic Fas mutations","volume":"351","author":"Holzelova","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"2023072611212395300_bib24","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.immuni.2007.12.017","article-title":"Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity","volume":"28","author":"Hughes","year":"2008","journal-title":"Immunity."},{"key":"2023072611212395300_bib25","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/0161-5890(88)90161-7","article-title":"Enhancement of the activities of glycosyltransferases involved in the biosynthesis of mucin-type sugar chains in autoimmune MRL lpr\/lpr mouse T cells","volume":"25","author":"Imai","year":"1988","journal-title":"Mol. Immunol."},{"key":"2023072611212395300_bib26","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/ni1268","article-title":"Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin","volume":"6","author":"Intlekofer","year":"2005","journal-title":"Nat. Immunol."},{"key":"2023072611212395300_bib27","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1038\/ni.2153","article-title":"Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits the formation of memory CD8+ T cells","volume":"12","author":"Ji","year":"2011","journal-title":"Nat. Immunol."},{"key":"2023072611212395300_bib28","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.immuni.2007.07.010","article-title":"Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor","volume":"27","author":"Joshi","year":"2007","journal-title":"Immunity."},{"key":"2023072611212395300_bib29","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/nri3307","article-title":"Transcriptional control of effector and memory CD8+ T cell differentiation","volume":"12","author":"Kaech","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"2023072611212395300_bib30","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1172\/JCI81217","article-title":"Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy","volume":"126","author":"Klebanoff","year":"2016","journal-title":"J. Clin. Invest."},{"key":"2023072611212395300_bib31","doi-asserted-by":"publisher","first-page":"147","DOI":"10.4049\/jimmunol.1601218","article-title":"Sensitivity to Restimulation-induced cell death is linked to glycolytic metabolism in human T cells","volume":"198","author":"Larsen","year":"2017","journal-title":"J. Immunol."},{"key":"2023072611212395300_bib32","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.3389\/fimmu.2017.01216","article-title":"CD95\/Fas, non-apoptotic signaling pathways, and kinases","volume":"8","author":"Le Gallo","year":"2017","journal-title":"Front. Immunol."},{"key":"2023072611212395300_bib33","author":"Li","year":"2013"},{"key":"2023072611212395300_bib34","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics."},{"key":"2023072611212395300_bib35","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"2023072611212395300_bib36","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/1471-2105-10-161","article-title":"GAGE: generally applicable gene set enrichment for pathway analysis","volume":"10","author":"Luo","year":"2009","journal-title":"BMC Bioinformatics."},{"key":"2023072611212395300_bib37","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1681\/ASN.2014121214","article-title":"Double-negative \u03b1\u03b2 T cells are early responders to AKI and are found in human kidney","volume":"27","author":"Martina","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"2023072611212395300_bib38","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1182\/blood-2014-09-602763","article-title":"Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations","volume":"125","author":"Milner","year":"2015","journal-title":"Blood."},{"key":"2023072611212395300_bib39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003465","article-title":"Fas-mediated apoptosis regulates the composition of peripheral alphabeta T cell repertoire by constitutively purging out double negative T cells","volume":"3","author":"Mohamood","year":"2008","journal-title":"PLoS One."},{"key":"2023072611212395300_bib40","doi-asserted-by":"crossref","first-page":"328","DOI":"10.4049\/jimmunol.142.1.328","article-title":"Studies of c-myb gene regulation in MRL-lpr\/lpr mice. Identification of a 5\u2032 c-myb nuclear protein binding site and high levels of binding factors in nuclear extracts of lpr\/lpr lymph node cells","volume":"142","author":"Mountz","year":"1989","journal-title":"J. Immunol."},{"key":"2023072611212395300_bib41","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1126\/science.6494925","article-title":"Autoimmunity and increased c-myb transcription","volume":"226","author":"Mountz","year":"1984","journal-title":"Science."},{"key":"2023072611212395300_bib42","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s00401-016-1658-6","article-title":"Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis","volume":"133","author":"M\u00fcller","year":"2017","journal-title":"Acta Neuropathol."},{"key":"2023072611212395300_bib43","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.clim.2017.05.021","article-title":"STAT3 gain-of-function mutations associated with autoimmune lymphoproliferative syndrome like disease deregulate lymphocyte apoptosis and can be targeted by BH3 mimetic compounds","volume":"181","author":"Nabhani","year":"2017","journal-title":"Clin. Immunol."},{"key":"2023072611212395300_bib44","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1046\/j.1365-2141.2002.03848.x","article-title":"Dominant expression of interleukin 10 but not interferon gamma in CD4(-)CD8(-)alphabetaT cells of autoimmune lymphoproliferative syndrome","volume":"119","author":"Ohga","year":"2002","journal-title":"Br. J. Haematol."},{"key":"2023072611212395300_bib45","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1126\/science.284.5417.1187","article-title":"Inactivation of misselected CD8 T cells by CD8 gene methylation and cell death","volume":"284","author":"Pestano","year":"1999","journal-title":"Science."},{"key":"2023072611212395300_bib46","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.cell.2007.04.031","article-title":"The CD95 receptor: apoptosis revisited","volume":"129","author":"Peter","year":"2007","journal-title":"Cell."},{"key":"2023072611212395300_bib47","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1182\/blood-2013-10-535393","article-title":"Natural history of autoimmune lymphoproliferative syndrome associated with FAS gene mutations","volume":"123","author":"Price","year":"2014","journal-title":"Blood."},{"key":"2023072611212395300_bib48","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.immuni.2009.10.010","article-title":"The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin","volume":"32","author":"Rao","year":"2010","journal-title":"Immunity."},{"key":"2023072611212395300_bib49","article-title":"R: a language and environment for statistical computing.","author":"R Core Team","year":"2015"},{"key":"2023072611212395300_bib50","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1182\/blood-2014-03-564286","article-title":"Abnormally differentiated CD4+ or CD8+ T cells with phenotypic and genetic features of double negative T cells in human Fas deficiency","volume":"124","author":"Rensing-Ehl","year":"2014","journal-title":"Blood."},{"key":"2023072611212395300_bib51","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1126\/science.7539157","article-title":"Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity","volume":"268","author":"Rieux-Laucat","year":"1995","journal-title":"Science."},{"key":"2023072611212395300_bib52","doi-asserted-by":"publisher","first-page":"4409","DOI":"10.1073\/pnas.90.10.4409","article-title":"Mature T cells of autoimmune lpr\/lpr mice have a defect in antigen-stimulated suicide","volume":"90","author":"Russell","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072611212395300_bib53","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1016\/j.cell.2018.10.022","article-title":"Impact of genetic polymorphisms on human immune cell gene expression","volume":"175","author":"Schmiedel","year":"2018","journal-title":"Cell."},{"key":"2023072611212395300_bib54","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072611212395300_bib55","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1292\/jvms.62.29","article-title":"Involvement of CD28\/CTLA4-B7 costimulatory pathway in the development of lymphadenopathy and splenomegaly in MRL\/lpr mice","volume":"62","author":"Takiguchi","year":"2000","journal-title":"J. Vet. Med. Sci."},{"key":"2023072611212395300_bib56","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/j.1365-2141.2009.07595.x","article-title":"Treatment with sirolimus results in complete responses in patients with autoimmune lymphoproliferative syndrome","volume":"145","author":"Teachey","year":"2009","journal-title":"Br. J. Haematol."},{"key":"2023072611212395300_bib57","doi-asserted-by":"publisher","first-page":"4960","DOI":"10.4049\/jimmunol.168.10.4960","article-title":"Fas-dependent elimination of nonselected CD8 cells and lpr disease","volume":"168","author":"Trimble","year":"2002","journal-title":"J. Immunol."},{"key":"2023072611212395300_bib58","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1002\/cyto.a.22625","article-title":"FlowSOM: Using self-organizing maps for visualization and interpretation of cytometry data","volume":"87","author":"Van Gassen","year":"2015","journal-title":"Cytometry A."},{"key":"2023072611212395300_bib59","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1182\/blood-2015-11-685024","article-title":"Hyperactive mTOR pathway promotes lymphoproliferation and abnormal differentiation in autoimmune lymphoproliferative syndrome","volume":"128","author":"V\u00f6lkl","year":"2016","journal-title":"Blood."},{"key":"2023072611212395300_bib60","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1515\/hsz-2014-0212","article-title":"Principles and mechanisms of CD95 activation","volume":"395","author":"Wajant","year":"2014","journal-title":"Biol. Chem."},{"key":"2023072611212395300_bib61","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.1002\/eji.1830261215","article-title":"Homeostatic regulation of CD8+ T cells after antigen challenge in the absence of Fas (CD95)","volume":"26","author":"Zimmermann","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"2023072611212395300_bib62","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.jaut.2007.05.001","article-title":"OBF-1 is essential for the generation of antibody-secreting cells and the development of autoimmunity in MRL-lpr mice","volume":"29","author":"Zuo","year":"2007","journal-title":"J. Autoimmun."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20192191\/1769674\/jem_20192191.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20192191\/1769674\/jem_20192191.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T11:23:44Z","timestamp":1690370624000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/218\/2\/e20192191\/211525\/A-distinct-CD38-CD45RA-population-of-CD4-CD8-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,10]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20192191","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,10]]},"article-number":"e20192191"}}