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However, the impact of CMV in young adults is less clear. In this study, healthy UK and Senegalese adults aged 18\u201350 yr (average, 29 yr) were vaccinated with the Ebola vaccine candidate chimpanzee adenovirus type 3\u2013vectored Ebola Zaire vaccine (ChAd3-EBO-Z) and boosted with modified vaccinia Ankara Ebola Zaire\u2013vectored (MVA\u2013EBO-Z) vaccine. CMV carriage was associated with an expansion of phenotypically senescent CD4+ and CD8+ T cells expressing CD57 and killer cell lectin-like receptor G1 (KLRG1), which was negatively associated with vaccine responses in both cohorts. Ebola-specific T cell responses induced by vaccination also contained significantly increased frequencies of terminally differentiated CD57+KLRG1+ cells in CMV seropositive (CMV+) individuals. This study suggests that CMV can also affect vaccine responses in younger adults and may have a particularly marked impact in many developing countries where CMV seroprevalence is almost universal.<\/jats:p>","DOI":"10.1084\/jem.20200004","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T02:21:27Z","timestamp":1587003687000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":54,"title":["Reduced Ebola vaccine responses in CMV+ young adults is associated with expansion of CD57+KLRG1+ T cells"],"prefix":"10.1084","volume":"217","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2058-4045","authenticated-orcid":true,"given":"Georgina","family":"Bowyer","sequence":"first","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford, UK 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1194-2429","authenticated-orcid":true,"given":"Hannah","family":"Sharpe","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford, UK 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navin","family":"Venkatraman","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford, UK 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6882-6325","authenticated-orcid":true,"given":"Pierre Birahim","family":"Ndiaye","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire le Dantec, Dakar, Senegal 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1321-365X","authenticated-orcid":true,"given":"Djibril","family":"Wade","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire le Dantec, Dakar, Senegal 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7690-4925","authenticated-orcid":true,"given":"Nicole","family":"Brenner","sequence":"additional","affiliation":[{"name":"Infections and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4502-2209","authenticated-orcid":true,"given":"Alex","family":"Mentzer","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford, UK 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Mair","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford, UK 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Waterboer","sequence":"additional","affiliation":[{"name":"Infections and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Lambe","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford, UK 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tandakha","family":"Dieye","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire le Dantec, Dakar, Senegal 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7968-3320","authenticated-orcid":true,"given":"Souleymane","family":"Mboup","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire le Dantec, Dakar, Senegal 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian V.S.","family":"Hill","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford, UK 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9827-9836","authenticated-orcid":true,"given":"Katie J.","family":"Ewer","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford, UK 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2020,5,15]]},"reference":[{"key":"2023072617371743700_bib1","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.3389\/fmicb.2015.01016","article-title":"Ongoing burden of disease and mortality from HIV\/CMV coinfection in Africa in the antiretroviral therapy era","volume":"6","author":"Adland","year":"2015","journal-title":"Front. 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