{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:11:00Z","timestamp":1790323860259,"version":"4.1.0"},"reference-count":46,"publisher":"Rockefeller University Press","issue":"10","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.rupress.org\/terms\/"},{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"vor","delay-in-days":252,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 HL135752"],"award-info":[{"award-number":["R35 HL135752"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 HL131478"],"award-info":[{"award-number":["P01 HL131478"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 HL142494"],"award-info":[{"award-number":["P01 HL142494"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["17EIA33410439"],"award-info":[{"award-number":["17EIA33410439"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Patricia and Scott Eston MGH Research Scholar"},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["AHA 19POST34380057"],"award-info":[{"award-number":["AHA 19POST34380057"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001645","name":"Boehringer Ingelheim Fonds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10,5]]},"abstract":"<jats:p>The thymus is a primary lymphoid organ necessary for optimal T cell development. Here, we show that liver X receptors (LXRs)\u2014a class of nuclear receptors and transcription factors with diverse functions in metabolism and immunity\u2014critically contribute to thymic integrity and function. LXR\u03b1\u03b2-deficient mice develop a fatty, rapidly involuting thymus and acquire a shrunken and prematurely immunoinhibitory peripheral T cell repertoire. LXR\u03b1\u03b2\u2019s functions are cell specific, and the resulting phenotypes are mutually independent. Although thymic macrophages require LXR\u03b1\u03b2 for cholesterol efflux, thymic epithelial cells (TECs) use LXR\u03b1\u03b2 for self-renewal and thymocytes for negative selection. Consequently, TEC-derived LXR\u03b1\u03b2 protects against homeostatic premature involution and orchestrates thymic regeneration following stress, while thymocyte-derived LXR\u03b1\u03b2 limits cell disposal during negative selection and confers heightened sensitivity to experimental autoimmune encephalomyelitis. These results identify three distinct but complementary mechanisms by which LXR\u03b1\u03b2 governs T lymphocyte education and illuminate LXR\u03b1\u03b2\u2019s indispensable roles in adaptive immunity.<\/jats:p>","DOI":"10.1084\/jem.20200318","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T02:21:45Z","timestamp":1592360505000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Liver X receptors are required for thymic resilience and T cell output"],"prefix":"10.1084","volume":"217","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1517-6530","authenticated-orcid":true,"given":"Christopher T.","family":"Chan","sequence":"first","affiliation":[{"name":"Center for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley M.","family":"Fenn","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina K.","family":"Harder","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2212-3904","authenticated-orcid":true,"given":"John E.","family":"Mindur","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron S.","family":"McAlpine","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Patel","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Valet","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5172-6456","authenticated-orcid":true,"given":"Sara","family":"Rattik","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"He","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Anzai","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Kahles","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram C.","family":"Poller","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrike","family":"Janssen","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai Ping","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, Boston, MA 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3950-1924","authenticated-orcid":true,"given":"Carlos","family":"Fernandez-Hernando","sequence":"additional","affiliation":[{"name":"Vascular Biology and Therapeutics Program, Department of Comparative Medicine and Pathology, Yale University School of Medicine, New Haven, CT 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Koolbergen","sequence":"additional","affiliation":[{"name":"Heart Center, Department of Cardiothoracic Surgery, Amsterdam Universitair Medische Centra, University of Amsterdam, Amsterdam, Netherlands 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja M.","family":"van der Laan","sequence":"additional","affiliation":[{"name":"Heart Center, Department of Cardiology, Amsterdam Universitair Medische Centra, University of Amsterdam, Amsterdam, Netherlands 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Yvan-Charvet","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Universit\u00e9 C\u00f4te d\u2019Azur, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire, Atip-Avenir, F\u00e9d\u00e9ration Hospitalo-Universitaire Oncoage, Nice, France 6"},{"name":"Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruslan I.","family":"Sadreyev","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Department of Pathology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4021-1887","authenticated-orcid":true,"given":"Matthias","family":"Nahrendorf","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marit","family":"Westerterp","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 7"},{"name":"Department of Pediatrics, Section Molecular Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R.","family":"Tall","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Ake","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX 10"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3163-9152","authenticated-orcid":true,"given":"Filip K.","family":"Swirski","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2020,7,27]]},"reference":[{"key":"2026041423504072700_bib1","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.immuni.2009.06.018","article-title":"Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR","volume":"31","author":"A-Gonzalez","year":"2009","journal-title":"Immunity"},{"key":"2026041423504072700_bib2","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1146\/annurev-immunol-051116-052320","article-title":"Thymic Epithelial Cells","volume":"35","author":"Abramson","year":"2017","journal-title":"Annu. Rev. Immunol"},{"key":"2026041423504072700_bib3","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"2026041423504072700_bib4","first-page":"437","article-title":"The origin and implication of thymic involution","volume":"2","author":"Aw","year":"2011","journal-title":"Aging Dis"},{"key":"2026041423504072700_bib5","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.cell.2008.04.052","article-title":"LXR signaling couples sterol metabolism to proliferation in the acquired immune response","volume":"134","author":"Bensinger","year":"2008","journal-title":"Cell"},{"key":"2026041423504072700_bib6","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1038\/415922a","article-title":"BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes","volume":"415","author":"Bouillet","year":"2002","journal-title":"Nature"},{"key":"2026041423504072700_bib7","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/imr.12418","article-title":"Thymus: the next (re)generation","volume":"271","author":"Chaudhry","year":"2016","journal-title":"Immunol. Rev"},{"key":"2026041423504072700_bib8","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1002\/2211-5463.12194","article-title":"PDGF-induced fibroblast growth requires monounsaturated fatty acid production by stearoyl-CoA desaturase","volume":"7","author":"Coomans de Brach\u00e8ne","year":"2017","journal-title":"FEBS Open Bio"},{"key":"2026041423504072700_bib9","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1172\/JCI42974","article-title":"Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation","volume":"121","author":"Cui","year":"2011","journal-title":"J. Clin. Invest"},{"key":"2026041423504072700_bib10","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1084\/jem.20121458","article-title":"Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-\u03baB","volume":"210","author":"Daley","year":"2013","journal-title":"J. Exp. Med"},{"key":"2026041423504072700_bib11","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2026041423504072700_bib12","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1126\/science.1218004","article-title":"Interleukin-22 drives endogenous thymic regeneration in mice","volume":"336","author":"Dudakov","year":"2012","journal-title":"Science"},{"key":"2026041423504072700_bib13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001566","article-title":"Elimination of self-reactive T cells in the thymus: a timeline for negative selection","volume":"11","author":"Dzhagalov","year":"2013","journal-title":"PLoS Biol"},{"key":"2026041423504072700_bib14","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.devcel.2016.06.029","article-title":"The Dynamics of Apoptotic Cell Clearance","volume":"38","author":"Elliott","year":"2016","journal-title":"Dev. Cell"},{"key":"2026041423504072700_bib15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pharmthera.2017.07.010","article-title":"The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease","volume":"181","author":"Fessler","year":"2018","journal-title":"Pharmacol. Ther"},{"key":"2026041423504072700_bib45","doi-asserted-by":"publisher","first-page":"3777","DOI":"10.1182\/blood-2006-02-004531","article-title":"Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells","volume":"108","author":"Gray","year":"2006","journal-title":"Blood"},{"key":"2026041423504072700_bib16","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nrd4280","article-title":"Liver X receptors in lipid metabolism: opportunities for drug discovery","volume":"13","author":"Hong","year":"2014","journal-title":"Nat. Rev. Drug Discov"},{"key":"2026041423504072700_bib17","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.3390\/cancers3022462","article-title":"Roles of StearoylCoA Desaturase-1 in the Regulation of Cancer Cell Growth, Survival and Tumorigenesis","volume":"3","author":"Igal","year":"2011","journal-title":"Cancers (Basel)"},{"key":"2026041423504072700_bib18","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1002\/1521-4141(200003)30:3&lt;954::AID-IMMU954&gt;3.0.CO;2-Y","article-title":"Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes","volume":"30","author":"Kabouridis","year":"2000","journal-title":"Eur. J. Immunol"},{"key":"2026041423504072700_bib19","doi-asserted-by":"publisher","first-page":"716","DOI":"10.4049\/jimmunol.176.2.716","article-title":"Modulation of Fas-mediated apoptosis by lipid rafts in T lymphocytes","volume":"176","author":"Legembre","year":"2006","journal-title":"J. Immunol"},{"key":"2026041423504072700_bib20","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/978-1-4939-1752-5_8","article-title":"Cholesterol depletion using methyl-\u03b2-cyclodextrin","volume":"1232","author":"Mahammad","year":"2015","journal-title":"Methods Mol. Biol"},{"key":"2026041423504072700_bib21","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.4049\/jimmunol.1701328","article-title":"Cutting edge: denovo glucocorticoid synthesis by thymic epithelial cells regulates antigen-specific thymocyte selection","volume":"200","author":"Mittelstadt","year":"2018","journal-title":"J. Immunol"},{"key":"2026041423504072700_bib22","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1084\/jem.20041685","article-title":"Role of membrane sphingomyelin and ceramide in platform formation for Fas-mediated apoptosis","volume":"202","author":"Miyaji","year":"2005","journal-title":"J. Exp. Med"},{"key":"2026041423504072700_bib23","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.1182\/blood-2007-06-096529","article-title":"Semaphorin3A signaling controls Fas (CD95)-mediated apoptosis by promoting Fas translocation into lipid rafts","volume":"111","author":"Moretti","year":"2008","journal-title":"Blood"},{"key":"2026041423504072700_bib24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026751","article-title":"Liver x receptors regulate the transcriptional activity of the glucocorticoid receptor: implications for the carbohydrate metabolism","volume":"7","author":"Nader","year":"2012","journal-title":"PLoS One"},{"key":"2026041423504072700_bib25","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1073\/pnas.1714478115","article-title":"Thymic involution and rising disease incidence with age","volume":"115","author":"Palmer","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026041423504072700_bib26","doi-asserted-by":"publisher","first-page":"E28","DOI":"10.1152\/ajpendo.90897.2008","article-title":"Biochemical and physiological function of stearoyl-CoA desaturase","volume":"297","author":"Paton","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab"},{"key":"2026041423504072700_bib27","doi-asserted-by":"publisher","first-page":"3299","DOI":"10.1194\/jlr.M009449","article-title":"Lipidomics reveals a remarkable diversity of lipids in human plasma","volume":"51","author":"Quehenberger","year":"2010","journal-title":"J. Lipid Res"},{"key":"2026041423504072700_bib28","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1124\/mol.106.022608","article-title":"Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting","volume":"70","author":"Quinet","year":"2006","journal-title":"Mol. Pharmacol"},{"key":"2026041423504072700_bib29","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cellimm.2018.01.020","article-title":"Macrophages and lipid metabolism","volume":"330","author":"Remmerie","year":"2018","journal-title":"Cell. Immunol"},{"key":"2026041423504072700_bib30","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"2026041423504072700_bib31","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.3389\/fimmu.2017.01636","article-title":"Transcriptional Regulation of T-Cell Lipid Metabolism: Implications for Plasma Membrane Lipid Rafts and T-Cell Function","volume":"8","author":"Robinson","year":"2017","journal-title":"Front. Immunol"},{"key":"2026041423504072700_bib32","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3389\/fimmu.2014.00019","article-title":"From pre-DP, post-DP, SP4, and SP8 Thymocyte Cell Counts to a Dynamical Model of Cortical and Medullary Selection","volume":"5","author":"Sawicka","year":"2014","journal-title":"Front. Immunol"},{"key":"2026041423504072700_bib33","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/j.immuni.2015.04.011","article-title":"The Autoimmunity-Associated Gene CLEC16A Modulates Thymic Epithelial Cell Autophagy and Alters T Cell Selection","volume":"42","author":"Schuster","year":"2015","journal-title":"Immunity"},{"key":"2026041423504072700_bib34","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1038\/ni.2681","article-title":"Sterols and oxysterols in immune cell function","volume":"14","author":"Spann","year":"2013","journal-title":"Nat. Immunol"},{"key":"2026041423504072700_bib35","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1038\/nri1484","article-title":"Strategies to enhance T-cell reconstitution in immunocompromised patients","volume":"4","author":"van den Brink","year":"2004","journal-title":"Nat. Rev. Immunol"},{"key":"2026041423504072700_bib46","doi-asserted-by":"publisher","first-page":"10055","DOI":"10.1038\/srep10055","article-title":"The transcription factor NR4A1 is essential for the development of a novel macrophage subset in the thymus","volume":"5","author":"Tacke","year":"2015","journal-title":"Sci Rep"},{"key":"2026041423504072700_bib36","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/ni.3462","article-title":"Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol","volume":"17","author":"Wang","year":"2016","journal-title":"Nat. Immunol"},{"key":"2026041423504072700_bib37","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.cell.2017.08.041","article-title":"Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages","volume":"171","author":"Wang","year":"2017","journal-title":"Cell"},{"key":"2026041423504072700_bib38","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/j.cmet.2017.04.005","article-title":"Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity","volume":"25","author":"Westerterp","year":"2017","journal-title":"Cell Metab"},{"key":"2026041423504072700_bib39","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1189\/jlb.1008600","article-title":"Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity","volume":"86","author":"Xu","year":"2009","journal-title":"J. Leukoc. Biol"},{"key":"2026041423504072700_bib40","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/282870","article-title":"Maturation and emigration of single-positive thymocytes","volume":"2013","author":"Xu","year":"2013","journal-title":"Clin. Dev. Immunol"},{"key":"2026041423504072700_bib41","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1007\/s11306-013-0511-3","article-title":"Stearoyl-CoA desaturase enzyme 1 inhibition reduces glucose utilization for de novo fatty acid synthesis and cell proliferation in 3T3-L1 adipocytes","volume":"9","author":"Yee","year":"2013","journal-title":"Metabolomics"},{"key":"2026041423504072700_bib42","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.celrep.2011.11.005","article-title":"The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence","volume":"1","author":"Youm","year":"2012","journal-title":"Cell Rep"},{"key":"2026041423504072700_bib43","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1126\/science.1189731","article-title":"ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation","volume":"328","author":"Yvan-Charvet","year":"2010","journal-title":"Science."},{"key":"2026041423504072700_bib44","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1161\/ATVBAHA.108.179283","article-title":"Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses","volume":"30","author":"Yvan-Charvet","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20200318\/1827874\/jem_20200318.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20200318\/1827874\/jem_20200318.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:50:49Z","timestamp":1776225049000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/217\/10\/e20200318\/151978\/Liver-X-receptors-are-required-for-thymic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,27]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10,5]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20200318","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,27]]},"article-number":"e20200318"}}