{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:03:06Z","timestamp":1790834586920,"version":"4.1.0"},"reference-count":65,"publisher":"Rockefeller University Press","issue":"3","license":[{"start":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:00:00Z","timestamp":1607644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/J00152X\/1"],"award-info":[{"award-number":["BB\/J00152X\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BBS\/E\/B\/000C0407"],"award-info":[{"award-number":["BBS\/E\/B\/000C0407"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BBS\/E\/B\/000C0427"],"award-info":[{"award-number":["BBS\/E\/B\/000C0427"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["200823\/Z\/16\/Z"],"award-info":[{"award-number":["200823\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:p>Cell migration relies on coordinated activity of chemotactic and guidance receptors. Here, we report a specific role for the RNA-binding protein ZFP36L1 in limiting the abundance of molecules involved in the homing of antibody-secreting cells (ASCs) to the bone marrow (BM). In the absence of ZFP36L1, ASCs build up in the spleen and the liver and show diminished accumulation in the BM. ZFP36L1 facilitates migration by directly regulating G protein\u2013coupled receptor kinase 2 (GRK2) and the integrin chains \u03b14 and \u03b21 in splenic ASCs. Expression of CXCR4 and of the integrins \u03b14 and \u03b21 is differentially regulated on ASCs produced at the early and late stages of the immune response. Consequently, deletion of the Zfp36l1 gene has a stronger effect on BM accumulation of high-affinity ASCs formed late in the response. Thus, ZFP36L1 is an integral part of the regulatory network controlling gene expression during ASC homing.<\/jats:p>","DOI":"10.1084\/jem.20200504","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T02:21:56Z","timestamp":1604024516000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Efficient homing of antibody-secreting cells to the bone marrow requires RNA-binding protein ZFP36L1"],"prefix":"10.1084","volume":"218","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0840-4774","authenticated-orcid":true,"given":"Alexander","family":"Saveliev","sequence":"first","affiliation":[{"name":"Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3249-707X","authenticated-orcid":true,"given":"Sarah E.","family":"Bell","sequence":"additional","affiliation":[{"name":"Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3801-9896","authenticated-orcid":true,"given":"Martin","family":"Turner","sequence":"additional","affiliation":[{"name":"Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2020,12,11]]},"reference":[{"key":"2023072716230567000_bib1","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics."},{"key":"2023072716230567000_bib2","doi-asserted-by":"publisher","first-page":"E9630","DOI":"10.1073\/pnas.1809739115","article-title":"Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and \u03b21-integrin function","volume":"115","author":"Andreani","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072716230567000_bib3","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1126\/science.1208248","article-title":"GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood","volume":"333","author":"Arnon","year":"2011","journal-title":"Science."},{"key":"2023072716230567000_bib4","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1084\/jem.20121387","article-title":"BCL6 positively regulates AID and germinal center gene expression via repression of miR-155","volume":"209","author":"Basso","year":"2012","journal-title":"J. Exp. Med."},{"key":"2023072716230567000_bib5","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1084\/jem.189.9.1467","article-title":"Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice","volume":"189","author":"Berlin-Rufenach","year":"1999","journal-title":"J. Exp. Med."},{"key":"2023072716230567000_bib6","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.celrep.2016.08.068","article-title":"Efficient Plasma Cell Differentiation and Trafficking Require Cxcr4 Desensitization","volume":"17","author":"Biajoux","year":"2016","journal-title":"Cell Rep."},{"key":"2023072716230567000_bib7","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/nrm3599","article-title":"Integrin inactivators: balancing cellular functions in vitro and in vivo","volume":"14","author":"Bouvard","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023072716230567000_bib8","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1084\/jem.20010670","article-title":"The intestinal chemokine thymus-expressed chemokine (CCL25) attracts IgA antibody-secreting cells","volume":"195","author":"Bowman","year":"2002","journal-title":"J. Exp. Med."},{"key":"2023072716230567000_bib9","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.bbagrm.2013.02.003","article-title":"Tristetraprolin (TTP): interactions with mRNA and proteins, and current thoughts on mechanisms of action","volume":"1829","author":"Brooks","year":"2013","journal-title":"Biochim. Biophys. Acta."},{"key":"2023072716230567000_bib10","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1084\/jem.193.10.1149","article-title":"Chemoattractants induce a rapid and transient upregulation of monocyte \u03b14 integrin affinity for vascular cell adhesion molecule 1 which mediates arrest: an early step in the process of emigration","volume":"193","author":"Chan","year":"2001","journal-title":"J. Exp. Med."},{"key":"2023072716230567000_bib11","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.coi.2015.12.008","article-title":"Regulation of germinal center responses, memory B cells and plasma cell formation-an update","volume":"39","author":"Corcoran","year":"2016","journal-title":"Curr. Opin. Immunol."},{"key":"2023072716230567000_bib12","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1126\/science.aad5978","article-title":"RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence","volume":"352","author":"Galloway","year":"2016","journal-title":"Science."},{"key":"2023072716230567000_bib13","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1084\/jem.20150191","article-title":"c-Myb is required for plasma cell migration to bone marrow after immunization or infection","volume":"212","author":"Good-Jacobson","year":"2015","journal-title":"J. Exp. Med."},{"key":"2023072716230567000_bib14","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1084\/jem.192.4.495","article-title":"Subsecond induction of \u03b14 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions","volume":"192","author":"Grabovsky","year":"2000","journal-title":"J. Exp. Med."},{"key":"2023072716230567000_bib15","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1084\/jem.194.1.45","article-title":"A coordinated change in chemokine responsiveness guides plasma cell movements","volume":"194","author":"Hargreaves","year":"2001","journal-title":"J. Exp. Med."},{"key":"2023072716230567000_bib16","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1073\/pnas.1013168108","article-title":"Kr\u00fcppel-like factor 2 (KLF2) regulates B-cell reactivity, subset differentiation, and trafficking molecule expression","volume":"108","author":"Hart","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072716230567000_bib17","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.4049\/jimmunol.169.3.1277","article-title":"Chemotactic responsiveness toward ligands for CXCR3 and CXCR4 is regulated on plasma blasts during the time course of a memory immune response","volume":"169","author":"Hauser","year":"2002","journal-title":"J. Immunol."},{"key":"2023072716230567000_bib18","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/eji.1830160206","article-title":"Limiting dilution analysis of the B cell compartment in human bone marrow","volume":"16","author":"Hibi","year":"1986","journal-title":"Eur. J. Immunol."},{"key":"2023072716230567000_bib19","doi-asserted-by":"publisher","first-page":"13789","DOI":"10.1073\/pnas.0605944103","article-title":"Testing gene function early in the B cell lineage in mb1-cre mice","volume":"103","author":"Hobeika","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072716230567000_bib20","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/ni.1901","article-title":"Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia","volume":"11","author":"Hodson","year":"2010","journal-title":"Nat. Immunol."},{"key":"2023072716230567000_bib21","doi-asserted-by":"publisher","first-page":"5603","DOI":"10.4049\/jimmunol.1003464","article-title":"Plexin-D1 is a novel regulator of germinal centers and humoral immune responses","volume":"186","author":"Holl","year":"2011","journal-title":"J. Immunol."},{"key":"2023072716230567000_bib22","doi-asserted-by":"publisher","first-page":"5007","DOI":"10.1182\/blood-2008-03-144543","article-title":"Genetic perturbation of the putative cytoplasmic membrane-proximal salt bridge aberrantly activates \u03b1(4) integrins","volume":"112","author":"Imai","year":"2008","journal-title":"Blood."},{"key":"2023072716230567000_bib23","doi-asserted-by":"publisher","first-page":"2683","DOI":"10.1084\/jem.20061289","article-title":"Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism","volume":"203","author":"Kabashima","year":"2006","journal-title":"J. Exp. Med."},{"key":"2023072716230567000_bib24","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1182\/blood-2003-12-4157","article-title":"Integrin \u03b14\u03b27 and its counterreceptor MAdCAM-1 contribute to hematopoietic progenitor recruitment into bone marrow following transplantation","volume":"104","author":"Katayama","year":"2004","journal-title":"Blood."},{"key":"2023072716230567000_bib25","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1101\/gr.229102","article-title":"The human genome browser at UCSC","volume":"12","author":"Kent","year":"2002","journal-title":"Genome Res."},{"key":"2023072716230567000_bib26","doi-asserted-by":"publisher","first-page":"721","DOI":"10.3389\/fimmu.2019.00721","article-title":"The Maintenance of Memory Plasma Cells","volume":"10","author":"Khodadadi","year":"2019","journal-title":"Front. Immunol."},{"key":"2023072716230567000_bib27","doi-asserted-by":"publisher","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","article-title":"TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions","volume":"14","author":"Kim","year":"2013","journal-title":"Genome Biol."},{"key":"2023072716230567000_bib28","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/ni1357","article-title":"Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination","volume":"7","author":"Klein","year":"2006","journal-title":"Nat. Immunol."},{"key":"2023072716230567000_bib29","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1084\/jem.193.6.741","article-title":"Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow","volume":"193","author":"Koni","year":"2001","journal-title":"J. Exp. Med."},{"key":"2023072716230567000_bib30","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.immuni.2008.04.014","article-title":"Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development","volume":"28","author":"Kwon","year":"2008","journal-title":"Immunity."},{"key":"2023072716230567000_bib31","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1084\/jem.193.6.755","article-title":"Neonatally induced inactivation of the vascular cell adhesion molecule 1 gene impairs B cell localization and T cell-dependent humoral immune response","volume":"193","author":"Leuker","year":"2001","journal-title":"J. Exp. Med."},{"key":"2023072716230567000_bib32","doi-asserted-by":"publisher","first-page":"4273","DOI":"10.1038\/ncomms5273","article-title":"Shp1 signalling is required to establish the long-lived bone marrow plasma cell pool","volume":"5","author":"Li","year":"2014","journal-title":"Nat. Commun."},{"key":"2023072716230567000_bib33","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1177\/40.8.1377736","article-title":"Distribution of the extracellular matrix proteins tenascin, fibronectin, and vitronectin in fetal, infant, and adult human spleens","volume":"40","author":"Liakka","year":"1992","journal-title":"J. Histochem. Cytochem."},{"key":"2023072716230567000_bib34","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"2023072716230567000_bib35","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1126\/science.1071632","article-title":"Integrin-mediated long-term B cell retention in the splenic marginal zone","volume":"297","author":"Lu","year":"2002","journal-title":"Science."},{"key":"2023072716230567000_bib36","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/imr.12743","article-title":"G-protein coupled receptors and ligands that organize humoral immune responses","volume":"289","author":"Lu","year":"2019","journal-title":"Immunol. Rev."},{"key":"2023072716230567000_bib37","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1084\/jem.20140338","article-title":"The miR-155-PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation","volume":"211","author":"Lu","year":"2014","journal-title":"J. Exp. Med."},{"key":"2023072716230567000_bib38","doi-asserted-by":"publisher","first-page":"424","DOI":"10.4049\/jimmunol.169.1.424","article-title":"Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis","volume":"169","author":"Luther","year":"2002","journal-title":"J. Immunol."},{"key":"2023072716230567000_bib39","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/40540","article-title":"Lifetime of plasma cells in the bone marrow","volume":"388","author":"Manz","year":"1997","journal-title":"Nature."},{"key":"2023072716230567000_bib40","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao2602","article-title":"The microanatomic segregation of selection by apoptosis in the germinal center","volume":"358","author":"Mayer","year":"2017","journal-title":"Science."},{"key":"2023072716230567000_bib41","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/ni.3349","article-title":"Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation","volume":"17","author":"Minnich","year":"2016","journal-title":"Nat. Immunol."},{"key":"2023072716230567000_bib42","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1089\/scd.2014.0551","article-title":"Evidence that \u03b27 integrin regulates hematopoietic stem cell homing and engraftment through interaction with MAdCAM-1","volume":"25","author":"Murakami","year":"2016","journal-title":"Stem Cells Dev."},{"key":"2023072716230567000_bib43","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/ni.3724","article-title":"Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1","volume":"18","author":"Newman","year":"2017","journal-title":"Nat. Immunol."},{"key":"2023072716230567000_bib44","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1038\/nri3795","article-title":"The generation of antibody-secreting plasma cells","volume":"15","author":"Nutt","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"2023072716230567000_bib45","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1182\/blood-2004-07-2507","article-title":"Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response","volume":"105","author":"Odendahl","year":"2005","journal-title":"Blood."},{"key":"2023072716230567000_bib46","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1172\/JCI31570","article-title":"Aberrant activation of integrin \u03b14\u03b27 suppresses lymphocyte migration to the gut","volume":"117","author":"Park","year":"2007","journal-title":"J. Clin. Invest."},{"key":"2023072716230567000_bib47","doi-asserted-by":"publisher","first-page":"3289","DOI":"10.1182\/blood.V95.11.3289","article-title":"The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial\/stromal migration and engraftment of NOD\/SCID mice","volume":"95","author":"Peled","year":"2000","journal-title":"Blood."},{"key":"2023072716230567000_bib48","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1002\/eji.201444637","article-title":"miR-148a promotes plasma cell differentiation and targets the germinal center transcription factors Mitf and Bach2","volume":"45","author":"Porstner","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"2023072716230567000_bib49","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1038\/nri1886","article-title":"Competence and competition: the challenge of becoming a long-lived plasma cell","volume":"6","author":"Radbruch","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"2023072716230567000_bib50","doi-asserted-by":"publisher","first-page":"W191","DOI":"10.1093\/nar\/gkz369","article-title":"g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)","volume":"47","author":"Raudvere","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2023072716230567000_bib51","doi-asserted-by":"publisher","first-page":"ra83","DOI":"10.1126\/scisignal.2000420","article-title":"Function of the nucleotide exchange activity of vav1 in T cell development and activation","volume":"2","author":"Saveliev","year":"2009","journal-title":"Sci. Signal."},{"key":"2023072716230567000_bib52","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.immuni.2006.07.009","article-title":"Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation","volume":"25","author":"Sciammas","year":"2006","journal-title":"Immunity."},{"key":"2023072716230567000_bib53","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/j.1600-065X.2012.01124.x","article-title":"Germinal center selection and the development of memory B and plasma cells","volume":"247","author":"Shlomchik","year":"2012","journal-title":"Immunol. Rev."},{"key":"2023072716230567000_bib54","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/S1074-7613(00)80541-5","article-title":"Humoral immunity due to long-lived plasma cells","volume":"8","author":"Slifka","year":"1998","journal-title":"Immunity."},{"key":"2023072716230567000_bib55","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1093\/emboj\/16.11.2996","article-title":"The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response","volume":"16","author":"Smith","year":"1997","journal-title":"EMBO J."},{"key":"2023072716230567000_bib56","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.coi.2017.03.006","article-title":"Plasma cell and memory B cell differentiation from the germinal center","volume":"45","author":"Suan","year":"2017","journal-title":"Curr. Opin. Immunol."},{"key":"2023072716230567000_bib57","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1084\/jem.187.6.885","article-title":"In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection","volume":"187","author":"Takahashi","year":"1998","journal-title":"J. Exp. Med."},{"key":"2023072716230567000_bib58","doi-asserted-by":"publisher","first-page":"3328","DOI":"10.4049\/jimmunol.1201042","article-title":"High rate of antibody secretion is not integral to plasma cell differentiation as revealed by XBP-1 deficiency","volume":"189","author":"Taubenheim","year":"2012","journal-title":"J. Immunol."},{"key":"2023072716230567000_bib59","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"2023072716230567000_bib60","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1146\/annurev-immunol-020711-075032","article-title":"Germinal centers","volume":"30","author":"Victora","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"2023072716230567000_bib61","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.immuni.2007.10.009","article-title":"microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells","volume":"27","author":"Vigorito","year":"2007","journal-title":"Immunity."},{"key":"2023072716230567000_bib62","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.4049\/jimmunol.1600854","article-title":"The RNA-Binding Proteins Zfp36l1 and Zfp36l2 Enforce the Thymic \u03b2-Selection Checkpoint by Limiting DNA Damage Response Signaling and Cell Cycle Progression","volume":"197","author":"Vogel","year":"2016","journal-title":"J. Immunol."},{"key":"2023072716230567000_bib63","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.immuni.2015.12.004","article-title":"A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells","volume":"44","author":"Weisel","year":"2016","journal-title":"Immunity."},{"key":"2023072716230567000_bib64","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1073\/pnas.1012858108","article-title":"B cell homeostasis and plasma cell homing controlled by Kr\u00fcppel-like factor 2","volume":"108","author":"Winkelmann","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072716230567000_bib65","doi-asserted-by":"publisher","first-page":"6764","DOI":"10.1038\/ncomms7764","article-title":"Mir-17-92 regulates bone marrow homing of plasma cells and production of immunoglobulin G2c","volume":"6","author":"Xu","year":"2015","journal-title":"Nat. Commun."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20200504\/1816748\/jem_20200504.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20200504\/1816748\/jem_20200504.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T12:23:59Z","timestamp":1690460639000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/218\/3\/e20200504\/211586\/Efficient-homing-of-antibody-secreting-cells-to"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,11]]},"references-count":65,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20200504","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,11]]},"article-number":"e20200504"}}