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This review highlights the advances in defining how this organism was first detected and the studies with T. gondii that contribute to our understanding of how the cytokine IFN-\u03b3 promotes control of vacuolar pathogens. In addition, the genetic tractability of this eukaryote organism has provided the foundation for studies into the diverse strategies that pathogens use to evade antimicrobial responses and now provides the opportunity to study the basis for latency. Thus, T. gondii remains a clinically relevant organism whose evolving interactions with the host immune system continue to teach lessons broadly relevant to host\u2013pathogen interactions.<\/jats:p>","DOI":"10.1084\/jem.20201314","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T01:21:36Z","timestamp":1634779296000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":72,"title":["Lessons from <i>Toxoplasma<\/i>: Host responses that mediate parasite control and the microbial effectors that subvert them"],"prefix":"10.1084","volume":"218","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9515-3442","authenticated-orcid":true,"given":"Eva-Maria","family":"Frickel","sequence":"first","affiliation":[{"name":"Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, UK 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3092-1428","authenticated-orcid":true,"given":"Christopher A.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"key":"2023072610055531600_bib1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004588","article-title":"IFN-gamma-inducible Irga6 mediates host resistance against Chlamydia trachomatis via autophagy","volume":"4","author":"Al-Zeer","year":"2009","journal-title":"PLoS One."},{"key":"2023072610055531600_bib2","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1073\/pnas.1313501111","article-title":"Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse","volume":"111","author":"Alaganan","year":"2014","journal-title":"Proc. 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