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Their gene expression profile closely overlapped with ovarian tumor-associated macrophages previously described in the omentum. Indeed, syngeneic epithelial ovarian tumor growth was strongly reduced following in vivo ablation of LYVE1hi macrophages, including in mice that received omentectomy to dissociate the role from omental macrophages. These data reveal that the peritoneal compartment contains at least four resident macrophage populations and that LYVE1hi mesothelial macrophages drive tumor growth independently of the omentum.<\/jats:p>","DOI":"10.1084\/jem.20210924","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T02:25:47Z","timestamp":1634264747000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":73,"title":["LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth"],"prefix":"10.1084","volume":"218","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6736-2781","authenticated-orcid":true,"given":"Nan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 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