{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:28:38Z","timestamp":1769156918053,"version":"3.49.0"},"reference-count":16,"publisher":"Rockefeller University Press","issue":"10","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.rupress.org\/terms\/"},{"start":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T00:00:00Z","timestamp":1649030400000},"content-version":"vor","delay-in-days":203,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P30857-B28"],"award-info":[{"award-number":["P30857-B28"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P34023-B"],"award-info":[{"award-number":["P34023-B"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P34266-B"],"award-info":[{"award-number":["P34266-B"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["Sonderforschungsbereich F83"],"award-info":[{"award-number":["Sonderforschungsbereich F83"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001821","name":"Vienna Science and Technology Fund","doi-asserted-by":"publisher","award":["LS18-058"],"award-info":[{"award-number":["LS18-058"]}],"id":[{"id":"10.13039\/501100001821","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10,4]]},"abstract":"<jats:p>L\u00f6fgren\u2019s syndrome is an acute form of sarcoidosis that is characterized by the activation of CD4+ T helper cells. In this issue of JEM, Greaves et al. (2021. J. Exp. Med.https:\/\/doi.org\/10.1084\/jem.20210785) identified a peptide derived from an airborne mold species that stimulates T cells of L\u00f6fgren\u2019s syndrome patients in an HLA-DR3\u2013restricted manner. An increased serum IgG antibody response to the full-length protein was also observed in those patients, indicating that the fungus Aspergillus nidulans might be the elusive microbial agent that drives acute sarcoidosis.<\/jats:p>","DOI":"10.1084\/jem.20211572","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T13:17:52Z","timestamp":1631539072000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["A fungal antigenic driver for L\u00f6fgren\u2019s syndrome sarcoidosis"],"prefix":"10.1084","volume":"218","author":[{"given":"Clarice X.","family":"Lim","sequence":"first","affiliation":[{"name":"Center for Pathobiochemistry & Genetics, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4349-0797","authenticated-orcid":true,"given":"Thomas","family":"Weichhart","sequence":"additional","affiliation":[{"name":"Center for Pathobiochemistry & Genetics, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"key":"2025042817022208500_bib1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01450-2019","author":"Darlington","year":"2020","journal-title":"Eur. Respir. J."},{"key":"2025042817022208500_bib2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI144864","author":"Falta","year":"2021","journal-title":"J. Clin. Invest."},{"key":"2025042817022208500_bib3","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210785","author":"Greaves","year":"2021","journal-title":"J. Exp. Med."},{"key":"2025042817022208500_bib4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200807-1082OC","author":"Grunewald","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025042817022208500_bib5","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01209-2015","author":"Grunewald","year":"2016","journal-title":"Eur. Respir. J."},{"key":"2025042817022208500_bib6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01130","author":"Kaiser","year":"2017","journal-title":"Front. Immunol."},{"key":"2025042817022208500_bib7","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.021532018","author":"Kaiser","year":"2019","journal-title":"Eur. Respir. J."},{"key":"2025042817022208500_bib8","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.03468-2020","author":"Lepzien","year":"2021","journal-title":"Eur. Respir. J."},{"key":"2025042817022208500_bib9","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.03794-2020","author":"Liao","year":"2021","journal-title":"Eur. Respir. J."},{"key":"2025042817022208500_bib10","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3655","author":"Linke","year":"2017","journal-title":"Nat. Immunol."},{"key":"2025042817022208500_bib11","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700570","author":"Mitchell","year":"2017","journal-title":"J. Immunol."},{"key":"2025042817022208500_bib12","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201707-565OT","author":"Moller","year":"2017","journal-title":"Ann. Am. Thorac. Soc."},{"key":"2025042817022208500_bib13","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-009-9311-y","author":"Oswald-Richter","year":"2010","journal-title":"J. Clin. Immunol."},{"key":"2025042817022208500_bib14","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2020.01.007","author":"Pacheco","year":"2020","journal-title":"Trends Immunol."},{"key":"2025042817022208500_bib15","doi-asserted-by":"publisher","DOI":"10.1177\/1753465811401648","author":"Ter\u010delj","year":"2011","journal-title":"Ther. Adv. Respir. Dis."},{"key":"2025042817022208500_bib16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60680-7","author":"Valeyre","year":"2014","journal-title":"Lancet."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20211572\/1834713\/jem_20211572.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20211572\/1834713\/jem_20211572.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T21:02:27Z","timestamp":1745874147000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/218\/10\/e20211572\/212640\/A-fungal-antigenic-driver-for-Lofgren-s-syndrome"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,13]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10,4]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20211572","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,13]]},"article-number":"e20211572"}}