{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T08:44:54Z","timestamp":1758271494454,"version":"3.41.2"},"reference-count":12,"publisher":"Rockefeller University Press","issue":"12","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.rupress.org\/terms\/"},{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":203,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12,6]]},"abstract":"<jats:p>The majority of humans infected with Mycobacterium tuberculosis never experience clinical symptoms or signs, but predicting those who will remains out of reach. Here, we discuss recent studies that reveal patterns and pathways that determine who is at highest risk for progression.<\/jats:p>","DOI":"10.1084\/jem.20211665","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T14:42:50Z","timestamp":1636987370000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Signature required: The transcriptional response to tuberculosis"],"prefix":"10.1084","volume":"218","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2927-270X","authenticated-orcid":true,"suffix":"III","given":"Clifton E.","family":"Barry","sequence":"first","affiliation":[{"name":"1Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0311-3233","authenticated-orcid":true,"given":"Katrin D.","family":"Mayer-Barber","sequence":"additional","affiliation":[{"name":"2Inflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"key":"2023072812510759500_bib1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202011-4239pp","author":"Behr","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2023072812510759500_bib2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09247","author":"Berry","year":"2010","journal-title":"Nature."},{"journal-title":"Int. J. Tuberc. Lung Dis.","year":"2008","author":"Davies","key":"2023072812510759500_bib3"},{"key":"2023072812510759500_bib4","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00021-18","author":"Drain","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"key":"2023072812510759500_bib5","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202006-2394PP","author":"Kendall","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2023072812510759500_bib6","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30045-X","author":"Mendelsohn","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"2023072812510759500_bib7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0237574","author":"Mulenga","year":"2020","journal-title":"PLoS One."},{"key":"2023072812510759500_bib9","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0225-9","author":"Singhania","year":"2018","journal-title":"Nat. Immunol."},{"key":"2023072812510759500_bib13","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210915","author":"Tabone","year":"2021","journal-title":"J. Exp. Med"},{"key":"2023072812510759500_bib10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002786","volume":"16","author":"Warsinske","year":"2019","journal-title":"PLoS Med."},{"year":"2021","author":"World Health Organization","key":"2023072812510759500_bib11"},{"key":"2023072812510759500_bib12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01316-1","author":"Zak","year":"2016","journal-title":"Lancet."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20211665\/1833074\/jem_20211665.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20211665\/1833074\/jem_20211665.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T12:51:52Z","timestamp":1690548712000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/218\/12\/e20211665\/212819\/Signature-required-The-transcriptional-response-to"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,15]]},"references-count":12,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12,6]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20211665","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"type":"print","value":"0022-1007"},{"type":"electronic","value":"1540-9538"}],"subject":[],"published":{"date-parts":[[2021,11,15]]},"article-number":"e20211665"}}