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Recent findings indicate that these plaques do not form spontaneously but are instead constructed by microglia, the tissue macrophages of the central nervous system. We discuss cellular, structural, functional, and gene expression criteria by which the microglial assembly of dense-core plaques in the Alzheimer\u2019s brain parallels the construction of granulomas by macrophages in other settings. We compare the genesis of these plaques to the macrophage assembly of mycobacterial granulomas, the defining histopathological features of tuberculosis. We suggest that if dense-core plaques are indeed granulomas, their simple disassembly may be contraindicated as an Alzheimer\u2019s therapy.<\/jats:p>","DOI":"10.1084\/jem.20212477","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T13:31:15Z","timestamp":1655904675000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["The dense-core plaques of Alzheimer\u2019s disease are granulomas"],"prefix":"10.1084","volume":"219","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5805-9855","authenticated-orcid":true,"given":"Greg","family":"Lemke","sequence":"first","affiliation":[{"name":"Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 1"},{"name":"Immunobiology and Microbial Pathogenesis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4752-5800","authenticated-orcid":true,"given":"Youtong","family":"Huang","sequence":"additional","affiliation":[{"name":"Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"2023072617053073000_bib1","first-page":"164","article-title":"The granulomatous inflammatory response. 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