{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:11:06Z","timestamp":1790788266625,"version":"4.1.0"},"reference-count":44,"publisher":"Rockefeller University Press","issue":"9","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.rupress.org\/terms\/"},{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["VI 762\/1-1"],"award-info":[{"award-number":["VI 762\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["405772731"],"award-info":[{"award-number":["405772731"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["PR727\/11-1"],"award-info":[{"award-number":["PR727\/11-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB900"],"award-info":[{"award-number":["SFB900"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["158989968"],"award-info":[{"award-number":["158989968"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015034","name":"RESIST","doi-asserted-by":"publisher","award":["390874280"],"award-info":[{"award-number":["390874280"]}],"id":[{"id":"10.13039\/100015034","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hannover Biomedical Research School"},{"name":"Zentrum f\u00fcr Infektionsbiologie"}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9,5]]},"abstract":"<jats:p>The innate and adaptive roles of \u03b3\u03b4 T cells and their clonal \u03b3\u03b4 T cell receptors (TCRs) in immune responses are still unclear. Recent studies of \u03b3\u03b4 TCR repertoire dynamics showed massive expansion of individual V\u03b41+ \u03b3\u03b4 T cell clones during viral infection. To judge whether such expansion is random or actually represents TCR-dependent adaptive immune responses, information about their cognate TCR ligands is required. Here, we used CRISPR\/Cas9-mediated screening to identify HLA-DRA, RFXAP, RFX5, and CIITA as required for target cell recognition of a CMV-induced V\u03b33V\u03b41+ TCR, and further characterization revealed a direct interaction of this V\u03b41+ TCR with the MHC II complex HLA-DR. Since MHC II is strongly upregulated by interferon-\u03b3, these results suggest an inflammation-induced MHC-dependent immune response of \u03b3\u03b4 T cells.<\/jats:p>","DOI":"10.1084\/jem.20212525","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T13:14:06Z","timestamp":1658236446000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":49,"title":["A CMV-induced adaptive human V\u03b41+ \u03b3\u03b4 T cell clone recognizes HLA-DR"],"prefix":"10.1084","volume":"219","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4514-2742","authenticated-orcid":true,"given":"Malte","family":"Deseke","sequence":"first","affiliation":[{"name":"Institute of Immunology, Hannover Medical School, Hannover, Germany 1"},{"name":"Excellence Cluster 2155 RESIST, Hannover Medical School, Hannover, Germany 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9339-3752","authenticated-orcid":true,"given":"Francesca","family":"Rampoldi","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School, Hannover, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7607-8571","authenticated-orcid":true,"given":"Inga","family":"Sandrock","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School, Hannover, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2589-3322","authenticated-orcid":true,"given":"Eva","family":"Borst","sequence":"additional","affiliation":[{"name":"Institute of Virology, Hannover Medical School, Hannover, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8969-2645","authenticated-orcid":true,"given":"Heike","family":"B\u00f6ning","sequence":"additional","affiliation":[{"name":"Institute of Virology, Hannover Medical School, Hannover, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5350-3371","authenticated-orcid":true,"given":"George Liam","family":"Ssebyatika","sequence":"additional","affiliation":[{"name":"Center of Structural and Cell Biology in Medicine, Institute of Biochemistry, University of L\u00fcbeck, L\u00fcbeck, Germany 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1418-1514","authenticated-orcid":true,"given":"Carina","family":"J\u00fcrgens","sequence":"additional","affiliation":[{"name":"Institute of Virology, Hannover Medical School, Hannover, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9788-7335","authenticated-orcid":true,"given":"Nina","family":"Pl\u00fcckebaum","sequence":"additional","affiliation":[{"name":"Institute of Virology, Hannover Medical School, Hannover, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0036-1079","authenticated-orcid":true,"given":"Maleen","family":"Beck","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School, Hannover, Germany 1"},{"name":"Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1033-6830","authenticated-orcid":true,"given":"Ahmed","family":"Hassan","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School, Hannover, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7555-9472","authenticated-orcid":true,"given":"Likai","family":"Tan","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School, Hannover, Germany 1"},{"name":"Institute of Systems Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8975-4479","authenticated-orcid":true,"given":"Abdi","family":"Demera","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School, Hannover, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1212-8189","authenticated-orcid":true,"given":"Anika","family":"Janssen","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School, Hannover, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6848-4097","authenticated-orcid":true,"given":"Peter","family":"Steinberger","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Medical University of Vienna, Vienna, Austria 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7025-1735","authenticated-orcid":true,"given":"Christian","family":"Koenecke","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School, Hannover, Germany 1"},{"name":"Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6395-4010","authenticated-orcid":true,"given":"Abel","family":"Viejo-Borbolla","sequence":"additional","affiliation":[{"name":"Institute of Virology, Hannover Medical School, Hannover, Germany 3"},{"name":"German Center for Infection Research, Partner Site Hamburg-Luebeck-Borstel-Riems, Hamburg, Germany 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1227-3933","authenticated-orcid":true,"given":"Martin","family":"Messerle","sequence":"additional","affiliation":[{"name":"Institute of Virology, Hannover Medical School, Hannover, Germany 3"},{"name":"German Center for Infection Research, Partner Site Hamburg-Luebeck-Borstel-Riems, Hamburg, Germany 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4548-7241","authenticated-orcid":true,"given":"Thomas","family":"Krey","sequence":"additional","affiliation":[{"name":"Excellence Cluster 2155 RESIST, Hannover Medical School, Hannover, Germany 2"},{"name":"Institute of Virology, Hannover Medical School, Hannover, Germany 3"},{"name":"Center of Structural and Cell Biology in Medicine, Institute of Biochemistry, University of L\u00fcbeck, L\u00fcbeck, Germany 4"},{"name":"Center for Structural Systems Biology, Hamburg, Germany 8"},{"name":"German Center for Infection Research, Partner Site Hamburg-Luebeck-Borstel-Riems, Hamburg, Germany 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8789-9578","authenticated-orcid":true,"given":"Immo","family":"Prinz","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School, Hannover, Germany 1"},{"name":"Excellence Cluster 2155 RESIST, Hannover Medical School, Hannover, Germany 2"},{"name":"Institute of Systems Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany 6"},{"name":"Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany 10"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2022,7,19]]},"reference":[{"key":"2023072122400798900_bib1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aav4036","article-title":"Generation and molecular recognition of melanoma-associated antigen-specific human \u03b3\u03b4 T cells","volume":"3","author":"Benveniste","year":"2018","journal-title":"Sci. Immunol."},{"key":"2023072122400798900_bib2","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1002\/eji.1830190718","article-title":"Specificity of human T lymphocytes expressing a gamma\/delta T cell antigen receptor. Recognition of a polymorphic determinant of HLA class I molecules by a gamma\/delta clone","volume":"19","author":"Ciccone","year":"1989","journal-title":"Eur. J. Immunol."},{"key":"2023072122400798900_bib3","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.4049\/jimmunol.1800257","article-title":"Multiple knockout of classical HLA class II \u03b2-chains by CRISPR\/Cas9 genome editing driven by a single guide RNA","volume":"202","author":"Crivello","year":"2019","journal-title":"J. Immunol."},{"key":"2023072122400798900_bib4","doi-asserted-by":"publisher","first-page":"14760","DOI":"10.1038\/ncomms14760","article-title":"Clonal selection in the human V\u03b41 T cell repertoire indicates \u03b3\u03b4 TCR-dependent adaptive immune surveillance","volume":"8","author":"Davey","year":"2017","journal-title":"Nat. Commun."},{"key":"2023072122400798900_bib5","doi-asserted-by":"publisher","first-page":"2437","DOI":"10.1002\/eji.1830220937","article-title":"Restricted diversity of V gamma 9-JP rearrangements in unstimulated human gamma\/delta T lymphocytes","volume":"22","author":"Delfau","year":"1992","journal-title":"Eur. J. Immunol."},{"key":"2023072122400798900_bib6","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.4049\/jimmunol.153.7.3093","article-title":"Identification of a novel HLA-B27 subtype by restriction analysis of a cytotoxic gamma delta T cell clone","volume":"153","author":"Del Porto","year":"1994","journal-title":"J. Immunol."},{"key":"2023072122400798900_bib7","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1038\/s41423-020-0503-y","article-title":"Ligand recognition by the \u03b3\u03b4 TCR and discrimination between homeostasis and stress conditions","volume":"17","author":"Deseke","year":"2020","journal-title":"Cell Mol. Immunol."},{"key":"2023072122400798900_bib8","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/nbt.3437","article-title":"Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9","volume":"34","author":"Doench","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"2023072122400798900_bib9","doi-asserted-by":"publisher","first-page":"800","DOI":"10.3390\/cells9040800","article-title":"Human \u03b3\u03b4 TCR repertoires in health and disease","volume":"9","author":"Fichtner","year":"2020","journal-title":"Cells"},{"key":"2023072122400798900_bib10","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.4049\/jimmunol.153.7.2890","article-title":"Human TCR-gamma\/delta alloreactive response to HLA-DR molecules. Comparison with response of TCR-alpha\/beta","volume":"153","author":"Flament","year":"1994","journal-title":"J. Immunol."},{"key":"2023072122400798900_bib11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006346","article-title":"Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration","volume":"13","author":"Gonz\u00e1lez-Motos","year":"2017","journal-title":"PLoS Pathog."},{"key":"2023072122400798900_bib12","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/s41590-018-0082-6","article-title":"Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells","volume":"19","author":"Hammer","year":"2018","journal-title":"Nat. Immunol."},{"key":"2023072122400798900_bib13","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aba9010","article-title":"Human \u03b3\u03b4 T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2","volume":"6","author":"Harly","year":"2021","journal-title":"Sci. Immunol."},{"key":"2023072122400798900_bib14","doi-asserted-by":"publisher","first-page":"482","DOI":"10.2144\/03353bm08","article-title":"Rapid selection of Drosophila S2 cells with the puromycin resistance gene","volume":"35","author":"Iwaki","year":"2003","journal-title":"Biotechniques"},{"key":"2023072122400798900_bib15","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/978-1-61779-974-7_21","article-title":"Production of recombinant antibodies in drosophila melanogaster s2 cells","volume":"907","author":"Johansson","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"2023072122400798900_bib16","doi-asserted-by":"publisher","first-page":"20156","DOI":"10.1074\/jbc.271.33.20156","article-title":"Expression of recombinant HLA-DR2 molecules: Replacement of the hydrophobic transmembrane region by a leucine zipper dimerization motif allows the assembly and secretion of soluble DR \u03b1\u03b2 heterodimers","volume":"271","author":"Kalandadze","year":"1996","journal-title":"J. Biol. Chem."},{"key":"2023072122400798900_bib17","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.immuni.2020.02.014","article-title":"Butyrophilin-2A1 directly binds germline-encoded regions of the V\u03b39V\u03b42 TCR and is essential for phosphoantigen sensing","volume":"52","author":"Karunakaran","year":"2020","journal-title":"Immunity"},{"key":"2023072122400798900_bib18","doi-asserted-by":"publisher","first-page":"2870","DOI":"10.1182\/bloodadvances.2019032409","article-title":"Identification of a tumor-specific allo-HLA-restricted \u03b3\u03b4TCR","volume":"3","author":"Kierkels","year":"2019","journal-title":"Blood Adv."},{"key":"2023072122400798900_bib19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000762","article-title":"The disulfide bonds in glycoprotein E2 of hepatitis C virus reveal the tertiary organization of the molecule","volume":"6","author":"Krey","year":"2010","journal-title":"PLoS Pathog."},{"key":"2023072122400798900_bib20","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1182\/blood-2017-05-787598","article-title":"CRISPR-mediated TCR replacement generates superior anticancer transgenic T-cells","volume":"131","author":"Legut","year":"2018","journal-title":"Blood"},{"key":"2023072122400798900_bib21","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1126\/science.aav3900","article-title":"A class of \u03b3\u03b4 T cell receptors recognize the underside of the antigen-presenting molecule MR1","volume":"366","author":"le Nours","year":"2019","journal-title":"Science"},{"key":"2023072122400798900_bib22","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/s41592-018-0305-7","article-title":"T cell antigen discovery via trogocytosis","volume":"16","author":"Li","year":"2019","journal-title":"Nat. Methods"},{"key":"2023072122400798900_bib23","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.coi.2015.06.002","article-title":"Early innate responses to pathogens: Pattern recognition by unconventional human T-cells","volume":"36","author":"Liuzzi","year":"2015","journal-title":"Curr. Opin. Immunol."},{"key":"2023072122400798900_bib24","doi-asserted-by":"publisher","first-page":"3163","DOI":"10.1073\/pnas.1621052114","article-title":"Sensing of cell stress by human \u03b3\u03b4 TCR-dependent recognition of annexin A2","volume":"114","author":"Marlin","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023072122400798900_bib25","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1038\/s41467-020-14921-w","article-title":"Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance","volume":"11","author":"Martens","year":"2020","journal-title":"Nat. Commun."},{"key":"2023072122400798900_bib26","doi-asserted-by":"publisher","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet J."},{"key":"2023072122400798900_bib27","doi-asserted-by":"crossref","first-page":"715","DOI":"10.4049\/jimmunol.139.3.715","article-title":"Differential presentation of HLA-DR, DQ, and DP restriction elements by interferon-\u03b3-treated dermal fibroblasts","volume":"139","author":"Maurer","year":"1987","journal-title":"J. Immunol."},{"key":"2023072122400798900_bib28","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1038\/s41590-018-0253-5","article-title":"The \u03b3\u03b4TCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness","volume":"19","author":"Melandri","year":"2018","journal-title":"Nat. Immunol."},{"key":"2023072122400798900_bib29","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1600-065X.2006.00479.x","article-title":"Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vgamma2Vdelta2 T cells: Discriminating friend from foe through the recognition of prenyl pyrophosphate antigens","volume":"215","author":"Morita","year":"2007","journal-title":"Immunol. Rev."},{"key":"2023072122400798900_bib30","doi-asserted-by":"publisher","first-page":"18649","DOI":"10.1073\/pnas.1922588117","article-title":"Microbial exposure drives polyclonal expansion of innate \u03b3\u03b4 T cells immediately after birth","volume":"117","author":"Ravens","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023072122400798900_bib31","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/ni.3686","article-title":"Human \u03b3\u03b4 T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection","volume":"18","author":"Ravens","year":"2017","journal-title":"Nat. Immunol."},{"key":"2023072122400798900_bib32","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay5516","article-title":"Butyrophilin 2A1 is essential for phosphoantigen reactivity by \u03b3\u03b4 T cells","volume":"367","author":"Rigau","year":"2020","journal-title":"Science"},{"key":"2023072122400798900_bib33","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: A Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"2023072122400798900_bib34","doi-asserted-by":"publisher","first-page":"31580","DOI":"10.1038\/srep31580","article-title":"Creation of an engineered APC system to explore and optimize the presentation of immunodominant peptides of major allergens","volume":"6","author":"Rosskopf","year":"2016","journal-title":"Sci. Rep."},{"key":"2023072122400798900_bib35","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.4049\/jimmunol.1502202","article-title":"Molecular analysis of lipid-reactive V\u03b41 \u03b3\u03b4 T cells identified by CD1c tetramers","volume":"196","author":"Roy","year":"2016","journal-title":"J. Immunol."},{"key":"2023072122400798900_bib36","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/j.jaci.2006.01.001","article-title":"Recognition of pollen-derived phosphatidyl-ethanolamine by human CD1d-restricted gamma delta T cells.","volume":"117","author":"Russano","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"2023072122400798900_bib37","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.immuni.2014.03.003","article-title":"The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human V\u03b39V\u03b42T Cells","volume":"40","author":"Sandstrom","year":"2014","journal-title":"Immunity"},{"key":"2023072122400798900_bib44","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1038\/leu.2012.374","article-title":"\u03b3\u03b4T cells elicited by CMV reactivation after allo-SCT cross-recognize CMV and leukemia","volume":"27","author":"Scheper","year":"2013","journal-title":"Leukemia"},{"key":"2023072122400798900_bib38","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abf0125","article-title":"A fetal wave of human type 3 effector \u03b3\u03b4 cells with restricted TCR diversity persists into adulthood","volume":"6","author":"Tan","year":"2021","journal-title":"Sci. Immunol."},{"key":"2023072122400798900_bib39","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1038\/ni.2713","article-title":"CD1d-lipid antigen recognition by the \u03b3\u03b4 TCR","volume":"14","author":"Uldrich","year":"2013","journal-title":"Nat. Immunol."},{"key":"2023072122400798900_bib40","doi-asserted-by":"publisher","first-page":"6209","DOI":"10.4049\/jimmunol.1000231","article-title":"Vgamma2Vdelta2 T cell receptor recognition of prenyl pyrophosphates is dependent on all CDRs","volume":"184","author":"Wang","year":"2010","journal-title":"J. Immunol."},{"key":"2023072122400798900_bib41","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/s41590-018-0304-y","article-title":"\u03b3\u03b4 TCR ligands: The quest to solve a 500-million-year-old mystery","volume":"20","author":"Willcox","year":"2019","journal-title":"Nat. Immunol."},{"key":"2023072122400798900_bib42","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/ni.2394","article-title":"Cytomegalovirus and tumor stress surveillance by binding of a human \u03b3\u03b4 T cell antigen receptor to endothelial protein C receptor","volume":"13","author":"Willcox","year":"2012","journal-title":"Nat. Immunol."},{"key":"2023072122400798900_bib43","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.jcyt.2017.12.014","article-title":"Large-scale expansion of V\u03b39V\u03b42 T cells with engineered K562 feeder cells in G-Rex vessels and their use as chimeric antigen receptor\u2013modified effector cells","volume":"20","author":"Xiao","year":"2018","journal-title":"Cytotherapy"}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20212525\/1456885\/jem_20212525.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20212525\/1456885\/jem_20212525.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T22:41:30Z","timestamp":1689979290000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/219\/9\/e20212525\/213357\/A-CMV-induced-adaptive-human-V-1-T-cell-clone"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,19]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9,5]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20212525","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,19]]},"article-number":"e20212525"}}