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diseases). Cells homozygous for the common P1104A TYK2 allele have selectively impaired responses to IL-23 (underlying isolated mycobacterial disease). We report three new forms of TYK2 deficiency in six patients from five families homozygous for rare TYK2 alleles (R864C, G996R, G634E, or G1010D) or compound heterozygous for P1104A and a rare allele (A928V). All these missense alleles encode detectable proteins. The R864C and G1010D alleles are hypomorphic and loss-of-function (LOF), respectively, across signaling pathways. By contrast, hypomorphic G996R, G634E, and A928V mutations selectively impair responses to IL-23, like P1104A. Impairment of the IL-23\u2013dependent induction of IFN-\u03b3 is the only mechanism of mycobacterial disease common to patients with complete TYK2 deficiency with or without TYK2 expression, partial TYK2 deficiency across signaling pathways, or rare or common partial TYK2 deficiency specific for IL-23 signaling.<\/jats:p>","DOI":"10.1084\/jem.20220094","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T13:44:55Z","timestamp":1662990295000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":74,"title":["Impaired IL-23\u2013dependent induction of IFN-\u03b3 underlies mycobacterial disease in patients with inherited TYK2 deficiency"],"prefix":"10.1084","volume":"219","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2421-7389","authenticated-orcid":true,"given":"Masato","family":"Ogishi","sequence":"first","affiliation":[{"name":"St Giles Laboratory of Human Genetics of Infectious Diseases, 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