{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:10:13Z","timestamp":1790536213777,"version":"4.1.0"},"reference-count":15,"publisher":"Rockefeller University Press","issue":"6","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.rupress.org\/terms\/"},{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6,6]]},"abstract":"<jats:p>In this issue of JEM, Bastard et al. (2022. J. Exp. Med.https:\/\/doi.org\/10.1084\/jem.20220028) show that a loss-of-function IFNAR1 allele is common in western Polynesians, while Duncan et al. (2022. J. Exp. Med.https:\/\/doi.org\/10.1084\/jem.20212427) report that a loss-of-function IFNAR2 allele is common in Inuits. Homozygotes lack type I IFN immunity but are selectively vulnerable to influenza, COVID-19 pneumonia, and complications of live-attenuated viral vaccines.<\/jats:p>","DOI":"10.1084\/jem.20220491","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T23:30:54Z","timestamp":1651275054000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Null <i>IFNAR1<\/i> and <i>IFNAR2<\/i> alleles are surprisingly common in the Pacific and Arctic"],"prefix":"10.1084","volume":"219","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1214-0302","authenticated-orcid":true,"given":"Isabelle","family":"Meyts","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University Hospitals Leuven, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"2023072707150730400_bib1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-022-01215-7","author":"Abolhassani","year":"2022","journal-title":"J. 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