{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:00:10Z","timestamp":1793761210160,"version":"4.6.1"},"reference-count":88,"publisher":"Rockefeller University Press","issue":"11","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11,7]]},"abstract":"<jats:p>Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-\u03b12 alone (five patients) or with IFN-\u03c9 (eight patients) from a cohort of 279 patients (4.7%) aged 6\u201373 yr with critical influenza pneumonia. Nine and four patients had antibodies neutralizing high and low concentrations, respectively, of IFN-\u03b12, and six and two patients had antibodies neutralizing high and low concentrations, respectively, of IFN-\u03c9. The patients\u2019 autoantibodies increased influenza A virus replication in both A549 cells and reconstituted human airway epithelia. The prevalence of these antibodies was significantly higher than that in the general population for patients &amp;lt;70 yr of age (5.7 vs. 1.1%, P = 2.2 \u00d7 10\u22125), but not &amp;gt;70 yr of age (3.1 vs. 4.4%, P = 0.68). The risk of critical influenza was highest in patients with antibodies neutralizing high concentrations of both IFN-\u03b12 and IFN-\u03c9 (OR = 11.7, P = 1.3 \u00d7 10\u22125), especially those &amp;lt;70 yr old (OR = 139.9, P = 3.1 \u00d7 10\u221210). We also identified 10 patients in additional influenza patient cohorts. Autoantibodies neutralizing type I IFNs account for \u223c5% of cases of life-threatening influenza pneumonia in patients &amp;lt;70 yr old.<\/jats:p>","DOI":"10.1084\/jem.20220514","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T02:21:00Z","timestamp":1660011660000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":134,"title":["Autoantibodies against type I IFNs in patients with critical influenza pneumonia"],"prefix":"10.1084","volume":"219","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9040-3289","authenticated-orcid":true,"given":"Qian","family":"Zhang","sequence":"first","affiliation":[{"name":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 1"},{"name":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France 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