{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:22:16Z","timestamp":1790680936039,"version":"4.1.0"},"reference-count":122,"publisher":"Rockefeller University Press","issue":"8","license":[{"start":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T00:00:00Z","timestamp":1687996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ADG-785917"],"award-info":[{"award-number":["ADG-785917"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National du Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,8,7]]},"abstract":"<jats:p>PML assembles into nuclear domains that have attracted considerable attention from cell and cancer biologists. Upon stress, PML nuclear bodies modulate sumoylation and other post-translational modifications, providing an integrated molecular framework for the multiple roles of PML in apoptosis, senescence, or metabolism. PML is both a sensor and an effector of oxidative stress. Emerging data has demonstrated its key role in promoting therapy response in several hematological malignancies. While these membrane-less nuclear hubs can enforce efficient cancer cell clearance, their downstream pathways deserve better characterization. PML NBs are druggable and their known modulators may have broader clinical utilities than initially thought.<\/jats:p>","DOI":"10.1084\/jem.20221213","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T02:20:48Z","timestamp":1686363648000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["The PML hub: An emerging actor of leukemia therapies"],"prefix":"10.1084","volume":"220","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3973-0807","authenticated-orcid":true,"given":"Domitille","family":"R\u00e9rolle","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02vjkv261","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Interdisciplinary Research in Biology, Coll\u00e8ge de France, Inserm, PSL Research University 1 , Paris, France"},{"id":[{"id":"https:\/\/ror.org\/05f82e368","id-type":"ROR","asserted-by":"publisher"}],"name":"Universit\u00e9 Paris Cit\u00e9, Inserm U944, CNRS, GenCellDis, Institut de Recherche Saint-Louis 2 , Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1113-4472","authenticated-orcid":true,"given":"Hugues","family":"de Th\u00e9","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02vjkv261","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Interdisciplinary Research in Biology, Coll\u00e8ge de France, Inserm, PSL Research University 1 , Paris, France"},{"id":[{"id":"https:\/\/ror.org\/05f82e368","id-type":"ROR","asserted-by":"publisher"}],"name":"Universit\u00e9 Paris Cit\u00e9, Inserm U944, CNRS, GenCellDis, Institut de Recherche Saint-Louis 2 , Paris, France"},{"name":"Chaire d'Oncologie Cellulaire et Mol\u00e9culaire, Coll\u00e8ge de France 3 , Paris, France"},{"name":"Service d'H\u00e9matologie Biologique, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital St. Louis 4 , Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2023,6,29]]},"reference":[{"key":"2024011816270812200_bib1","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/nm.3441","article-title":"Activation of a promyelocytic leukemia-tumor protein 53 axis underlies acute promyelocytic leukemia cure","volume":"20","author":"Ablain","year":"2014","journal-title":"Nat. Med."},{"key":"2024011816270812200_bib2","doi-asserted-by":"publisher","first-page":"118707","DOI":"10.1016\/j.bbamcr.2020.118707","article-title":"The promyelocytic leukemia protein isoform PML1 is an oncoprotein and a direct target of the antioxidant sulforaphane (SFN)","volume":"1867","author":"Alhazmi","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"2024011816270812200_bib3","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1139\/bcb-2019-0115","article-title":"PML isoform expression and DNA break location relative to PML nuclear bodies impacts the efficiency of homologous recombination","volume":"98","author":"Attwood","year":"2020","journal-title":"Biochem. Cell Biol"},{"key":"2024011816270812200_bib4","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1182\/blood-2011-03-345702","article-title":"How I treat adult T-cell leukemia\/lymphoma","volume":"118","author":"Bazarbachi","year":"2011","journal-title":"Blood"},{"key":"2024011816270812200_bib5","doi-asserted-by":"publisher","first-page":"14465","DOI":"10.1074\/jbc.M600457200","article-title":"Cytoplasmic function of mutant promyelocytic leukemia (PML) and PML-retinoic acid receptor-alpha","volume":"281","author":"Bellodi","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2024011816270812200_bib6","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1016\/j.chembiol.2021.04.014","article-title":"Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics","volume":"28","author":"Benoit","year":"2021","journal-title":"Cell Chem. Biol."},{"key":"2024011816270812200_bib7","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1038\/nature05029","article-title":"PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR","volume":"442","author":"Bernardi","year":"2006","journal-title":"Nature"},{"key":"2024011816270812200_bib8","doi-asserted-by":"publisher","first-page":"6299","DOI":"10.1038\/onc.2008.305","article-title":"Regulation of apoptosis by PML and the PML-NBs","volume":"27","author":"Bernardi","year":"2008","journal-title":"Oncogene"},{"key":"2024011816270812200_bib9","doi-asserted-by":"publisher","first-page":"677","DOI":"10.4161\/cc.6.6.4021","article-title":"SUMO is growing senescent","volume":"6","author":"Bischof","year":"2007","journal-title":"Cell Cycle"},{"key":"2024011816270812200_bib10","doi-asserted-by":"publisher","first-page":"3358","DOI":"10.1093\/emboj\/cdf341","article-title":"Deconstructing PML-induced premature senescence","volume":"21","author":"Bischof","year":"2002","journal-title":"EMBO J."},{"key":"2024011816270812200_bib11","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1038\/s43018-021-00264-y","article-title":"Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia","volume":"2","author":"Bosc","year":"2021","journal-title":"Nat. Cancer"},{"key":"2024011816270812200_bib12","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1016\/j.celrep.2014.05.016","article-title":"The ROS\/SUMO axis contributes to the response of acute myeloid leukemia cells to chemotherapeutic drugs","volume":"7","author":"Bossis","year":"2014","journal-title":"Cell Rep."},{"key":"2024011816270812200_bib13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1757-5036-3-3","article-title":"Assembly dynamics of PML nuclear bodies in living cells","volume":"3","author":"Brand","year":"2010","journal-title":"PMC Biophys."},{"key":"2024011816270812200_bib14","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000516","article-title":"Challenges and perspectives for therapeutic targeting of myeloproliferative neoplasms","volume":"5","author":"Brkic","year":"2020","journal-title":"HemaSphere"},{"key":"2024011816270812200_bib15","doi-asserted-by":"publisher","first-page":"3088","DOI":"10.1172\/JCI62129","article-title":"A metabolic prosurvival role for PML in breast cancer","volume":"122","author":"Carracedo","year":"2012","journal-title":"J. Clin. Invest."},{"key":"2024011816270812200_bib16","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1172\/JCI82897","article-title":"PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia","volume":"126","author":"Cole","year":"2016","journal-title":"J. Clin. Invest."},{"key":"2024011816270812200_bib17","doi-asserted-by":"publisher","first-page":"6192","DOI":"10.1158\/0008-5472.CAN-05-3792","article-title":"Characterization of endogenous human promyelocytic leukemia isoforms","volume":"66","author":"Condemine","year":"2006","journal-title":"Cancer Res."},{"key":"2024011816270812200_bib18","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1182\/blood-2004-04-1614","article-title":"PML mediates IFN-alpha-induced apoptosis in myeloma by regulating TRAIL induction","volume":"105","author":"Crowder","year":"2005","journal-title":"Blood"},{"key":"2024011816270812200_bib19","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201268","article-title":"JAK2V617F myeloproliferative neoplasm eradication by a novel interferon\/arsenic therapy involves PML","volume":"218","author":"Dagher","year":"2021","journal-title":"J. Exp. Med."},{"key":"2024011816270812200_bib20","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1182\/blood.V82.6.1858.1858","article-title":"PML protein expression in hematopoietic and acute promyelocytic leukemia cells","volume":"82","author":"Daniel","year":"1993","journal-title":"Blood"},{"key":"2024011816270812200_bib21","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1182\/blood-2014-04-572750","article-title":"ATL response to arsenic\/interferon therapy is triggered by SUMO\/PML\/RNF4-dependent Tax degradation","volume":"125","author":"Dassouki","year":"2015","journal-title":"Blood"},{"key":"2024011816270812200_bib22","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/s41419-019-1889-2","article-title":"Promyelocytic leukemia (PML) gene regulation: Implication towards curbing oncogenesis","volume":"10","author":"Datta","year":"2019","journal-title":"Cell Death Dis."},{"key":"2024011816270812200_bib23","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/S1097-2765(04)00062-0","article-title":"PML is a direct p53 target that modulates p53 effector functions","volume":"13","author":"de Stanchina","year":"2004","journal-title":"Mol. Cell"},{"key":"2024011816270812200_bib24","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.ccell.2017.10.002","article-title":"Acute promyelocytic leukemia: A paradigm for oncoprotein-targeted cure","volume":"32","author":"de Th\u00e9","year":"2017","journal-title":"Cancer Cell"},{"key":"2024011816270812200_bib25","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1083\/jcb.200604009","article-title":"Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR","volume":"175","author":"Dellaire","year":"2006","journal-title":"J. Cell Biol."},{"key":"2024011816270812200_bib26","doi-asserted-by":"publisher","first-page":"3447","DOI":"10.1182\/blood-2014-11-612416","article-title":"Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells","volume":"125","author":"El Hajj","year":"2015","journal-title":"Blood"},{"key":"2024011816270812200_bib27","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1084\/jem.20101095","article-title":"Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia","volume":"207","author":"El Hajj","year":"2010","journal-title":"J. Exp. Med."},{"key":"2024011816270812200_bib28","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1056\/NEJMc1509584","article-title":"Dactinomycin in NPM1-mutated acute myeloid leukemia","volume":"373","author":"Falini","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"2024011816270812200_bib29","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1182\/blood.2019004226","article-title":"NPM1-mutated acute myeloid leukemia: From bench to bedside","volume":"136","author":"Falini","year":"2020","journal-title":"Blood"},{"key":"2024011816270812200_bib30","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1158\/2159-8290.CD-16-0441","article-title":"Chemotherapy-resistant human acute myeloid leukemia cells are not enriched for leukemic stem cells but require oxidative metabolism","volume":"7","author":"Farge","year":"2017","journal-title":"Cancer Discov."},{"key":"2024011816270812200_bib31","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1101\/gad.14.16.2015","article-title":"PML is induced by oncogenic ras and promotes premature senescence","volume":"14","author":"Ferbeyre","year":"2000","journal-title":"Genes Dev."},{"key":"2024011816270812200_bib32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004579","article-title":"Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration","volume":"10","author":"Fu","year":"2014","journal-title":"PLoS Genet."},{"key":"2024011816270812200_bib33","first-page":"2023","article-title":"Heterogeneous nuclear expression of the promyelocytic leukemia (PML) protein in normal and neoplastic human tissues","volume":"149","author":"Gambacorta","year":"1996","journal-title":"Am. J. Pathol."},{"key":"2024011816270812200_bib34","doi-asserted-by":"publisher","first-page":"2653","DOI":"10.1016\/j.febslet.2014.02.007","article-title":"PML tumour suppression and beyond: Therapeutic implications","volume":"588","author":"Gamell","year":"2014","journal-title":"FEBS Lett."},{"key":"2024011816270812200_bib35","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.201900577","article-title":"Ubiquitin and SUMO conjugation as biomarkers of acute myeloid leukemias response to chemotherapies","volume":"3","author":"G\u00e2tel","year":"2020","journal-title":"Life Sci. Alliance"},{"key":"2024011816270812200_bib36","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.cmet.2018.09.002","article-title":"PML-regulated mitochondrial metabolism enhances chemosensitivity in human ovarian cancers","volume":"29","author":"Gentric","year":"2018","journal-title":"Cell Metabol."},{"key":"2024011816270812200_bib37","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1089\/jir.2010.0111","article-title":"Role of promyelocytic leukemia protein in host antiviral defense","volume":"31","author":"Geoffroy","year":"2011","journal-title":"J. Interferon Cytokine Res."},{"key":"2024011816270812200_bib38","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.1038\/s41375-021-01192-7","article-title":"Dactinomycin induces complete remission associated with nucleolar stress response in relapsed\/refractory NPM1-mutated AML","volume":"35","author":"Gionfriddo","year":"2021","journal-title":"Leukemia"},{"key":"2024011816270812200_bib39","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1126\/science.1189157","article-title":"PML regulates apoptosis at endoplasmic reticulum by modulating calcium release","volume":"330","author":"Giorgi","year":"2010","journal-title":"Science"},{"key":"2024011816270812200_bib40","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1038\/nrd4002","article-title":"Modulation of oxidative stress as an anticancer strategy","volume":"12","author":"Gorrini","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"2024011816270812200_bib41","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1111\/j.1432-1033.1996.0554z.x","article-title":"Interferon-modulated expression of genes encoding the nuclear-dot-associated proteins Sp100 and promyelocytic leukemia protein (PML)","volume":"238","author":"Gr\u00f6tzinger","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"2024011816270812200_bib42","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.185","article-title":"Deacetylation of the tumor suppressor protein PML regulates hydrogen peroxide-induced cell death","volume":"5","author":"Guan","year":"2014","journal-title":"Cell Death Dis."},{"key":"2024011816270812200_bib43","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/s41467-017-02427-x","article-title":"A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche","volume":"9","author":"Guarnerio","year":"2018","journal-title":"Nat. Commun."},{"key":"2024011816270812200_bib44","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1038\/emboj.2013.65","article-title":"SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia","volume":"32","author":"Guo","year":"2013","journal-title":"EMBO J."},{"key":"2024011816270812200_bib45","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.molcel.2014.04.030","article-title":"A cellular system that degrades misfolded proteins and protects against neurodegeneration","volume":"55","author":"Guo","year":"2014","journal-title":"Mol. Cell"},{"key":"2024011816270812200_bib46","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.1091\/mbc.e13-11-0692","article-title":"Control of antioxidative response by the tumor suppressor protein PML through regulating Nrf2 activity","volume":"25","author":"Guo","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"2024011816270812200_bib47","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1093\/jnci\/djh043","article-title":"Loss of the tumor suppressor PML in human cancers of multiple histologic origins","volume":"96","author":"Gurrieri","year":"2004","journal-title":"J. Natl. Cancer Inst."},{"key":"2024011816270812200_bib48","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.4161\/cc.24805","article-title":"Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner","volume":"12","author":"Haupt","year":"2013","journal-title":"Cell Cycle"},{"key":"2024011816270812200_bib49","doi-asserted-by":"publisher","first-page":"24420","DOI":"10.1074\/jbc.M802217200","article-title":"Acetylation of PML is involved in histone deacetylase inhibitor-mediated apoptosis","volume":"283","author":"Hayakawa","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2024011816270812200_bib50","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/S1535-6108(04)00082-0","article-title":"Phosphorylation of PML by mitogen-activated protein kinases plays a key role in arsenic trioxide-mediated apoptosis","volume":"5","author":"Hayakawa","year":"2004","journal-title":"Cancer Cell"},{"key":"2024011816270812200_bib51","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1158\/0008-5472.CAN-08-2831","article-title":"IFN-alpha-induced apoptosis in hepatocellular carcinoma involves promyelocytic leukemia protein and TRAIL independently of p53","volume":"69","author":"Herzer","year":"2009","journal-title":"Cancer Res."},{"key":"2024011816270812200_bib52","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1111\/bjh.13910","article-title":"Mutations affecting both the rearranged and the unrearranged PML alleles in refractory acute promyelocytic leukaemia","volume":"172","author":"Iaccarino","year":"2016","journal-title":"Br. J. Haematol."},{"key":"2024011816270812200_bib53","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1083\/jcb.147.2.221","article-title":"PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1","volume":"147","author":"Ishov","year":"1999","journal-title":"J. Cell Biol."},{"key":"2024011816270812200_bib54","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1038\/nature07016","article-title":"PML targeting eradicates quiescent leukaemia-initiating cells","volume":"453","author":"Ito","year":"2008","journal-title":"Nature"},{"key":"2024011816270812200_bib55","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1038\/nm.2882","article-title":"A PML\u2013PPAR-\u03b4 pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance","volume":"18","author":"Ito","year":"2012","journal-title":"Nat. Med."},{"key":"2024011816270812200_bib56","doi-asserted-by":"publisher","first-page":"14278","DOI":"10.1073\/pnas.1507540112","article-title":"PML IV\/ARF interaction enhances p53 SUMO-1 conjugation, activation, and senescence","volume":"112","author":"Ivanschitz","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024011816270812200_bib57","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.ccr.2010.06.003","article-title":"PML\/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3","volume":"18","author":"Jeanne","year":"2010","journal-title":"Cancer Cell"},{"key":"2024011816270812200_bib58","doi-asserted-by":"publisher","first-page":"6528","DOI":"10.1182\/blood-2009-03-211821","article-title":"Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia\/lymphoma (ATL)","volume":"113","author":"Kchour","year":"2009","journal-title":"Blood"},{"key":"2024011816270812200_bib59","doi-asserted-by":"publisher","first-page":"11133","DOI":"10.1158\/0008-5472.CAN-07-1342","article-title":"Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells","volume":"67","author":"Kim","year":"2007","journal-title":"Cancer Res."},{"key":"2024011816270812200_bib60","first-page":"1315","article-title":"The PML growth-suppressor has an altered expression in human oncogenesis","volume":"10","author":"Koken","year":"1995","journal-title":"Oncogene"},{"key":"2024011816270812200_bib61","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1002\/j.1460-2075.1994.tb06356.x","article-title":"The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion","volume":"13","author":"Koken","year":"1994","journal-title":"EMBO J."},{"key":"2024011816270812200_bib62","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.ceb.2018.03.011","article-title":"PML nuclear bodies: From architecture to function","volume":"52","author":"Lallemand-Breitenbach","year":"2018","journal-title":"Curr. Opin. Cell Biol."},{"key":"2024011816270812200_bib63","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/ncb1717","article-title":"Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4\/ubiquitin-mediated pathway","volume":"10","author":"Lallemand-Breitenbach","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"2024011816270812200_bib64","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1084\/jem.193.12.1361","article-title":"Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML\/retinoic acid receptor alpha degradation","volume":"193","author":"Lallemand-Breitenbach","year":"2001","journal-title":"J. Exp. Med."},{"key":"2024011816270812200_bib65","first-page":"1171","article-title":"Therapy resistance in APL","volume":"371","author":"Lehmann-Che","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"2024011816270812200_bib66","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1038\/s41467-018-04384-5","article-title":"Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia","volume":"9","author":"Lehmann-Che","year":"2018","journal-title":"Nat. Commun."},{"key":"2024011816270812200_bib67","doi-asserted-by":"publisher","first-page":"4549","DOI":"10.3390\/cancers14194549","article-title":"Regulating the p53 tumor suppressor network at PML biomolecular condensates","volume":"14","author":"Liebl","year":"2022","journal-title":"Cancers"},{"key":"2024011816270812200_bib68","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aba7791","article-title":"A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models","volume":"13","author":"Lightcap","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"2024011816270812200_bib69","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.ctrv.2017.01.004","article-title":"Clinical and biological effects of demethylating agents on solid tumours - a systematic review","volume":"54","author":"Linnekamp","year":"2017","journal-title":"Cancer Treat. Rev."},{"key":"2024011816270812200_bib70","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1182\/blood-2015-04-637678","article-title":"Varying responses of PML-RARA with different genetic mutations to arsenic trioxide","volume":"127","author":"Liu","year":"2016","journal-title":"Blood"},{"key":"2024011816270812200_bib71","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1038\/leu.2016.69","article-title":"Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia","volume":"30","author":"Madan","year":"2016","journal-title":"Leukemia"},{"key":"2024011816270812200_bib72","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00785-22","article-title":"PML alternative splice products differentially regulate HAdV productive infection","volume":"10","author":"Mai","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"2024011816270812200_bib73","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/sj.onc.1206886","article-title":"Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence","volume":"23","author":"Mallette","year":"2004","journal-title":"Oncogene"},{"key":"2024011816270812200_bib74","doi-asserted-by":"publisher","first-page":"14569","DOI":"10.1074\/jbc.M112.437392","article-title":"Trafficking of the transcription factor Nrf2 to promyelocytic leukemia-nuclear bodies: Implications for degradation of NRF2 in the nucleus","volume":"288","author":"Malloy","year":"2013","journal-title":"J. Biol. Chem."},{"key":"2024011816270812200_bib75","doi-asserted-by":"publisher","first-page":"3455","DOI":"10.1182\/blood-2014-11-611459","article-title":"Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells","volume":"125","author":"Martelli","year":"2015","journal-title":"Blood"},{"key":"2024011816270812200_bib76","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1182\/bloodadvances.2020003934","article-title":"Single-center experience with venetoclax combinations in patients with newly diagnosed and relapsed AML evolving from MPNs","volume":"5","author":"Masarova","year":"2021","journal-title":"Blood Adv."},{"key":"2024011816270812200_bib77","doi-asserted-by":"publisher","first-page":"3185","DOI":"10.1093\/nar\/gkad152","article-title":"PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates","volume":"51","author":"Mathavarajah","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"2024011816270812200_bib78","doi-asserted-by":"publisher","DOI":"10.1080\/23723556.2015.1074335","article-title":"Crosstalk between p53 modifiers at PML bodies","volume":"5","author":"Matt","year":"2018","journal-title":"Mol. Cell. Oncol."},{"key":"2024011816270812200_bib79","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/s41568-020-0246-1","article-title":"Inflammatory microenvironment remodelling by tumour cells after radiotherapy","volume":"20","author":"McLaughlin","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"2024011816270812200_bib80","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1016\/j.celrep.2016.07.082","article-title":"PML at mitochondria-associated membranes is critical for the repression of autophagy and cancer development","volume":"16","author":"Missiroli","year":"2016","journal-title":"Cell Rep."},{"key":"2024011816270812200_bib81","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/s41418-022-01095-9","article-title":"PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment","volume":"30","author":"Missiroli","year":"2023","journal-title":"Cell Death Differ."},{"key":"2024011816270812200_bib82","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1093\/emboj\/17.1.61","article-title":"Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus","volume":"17","author":"M\u00fcller","year":"1998","journal-title":"EMBO J."},{"key":"2024011816270812200_bib83","doi-asserted-by":"publisher","first-page":"2770","DOI":"10.1182\/blood.2021014267","article-title":"The SUMOylation inhibitor subasumstat potentiates rituximab activity by IFN1-dependent macrophage and NK cell stimulation","volume":"139","author":"Nakamura","year":"2022","journal-title":"Blood"},{"key":"2024011816270812200_bib84","doi-asserted-by":"publisher","first-page":"4576","DOI":"10.1182\/blood-2002-09-2986","article-title":"Arsenic\/interferon specifically reverses 2 distinct gene networks critical for the survival of HTLV-1-infected leukemic cells","volume":"101","author":"Nasr","year":"2003","journal-title":"Blood"},{"key":"2024011816270812200_bib85","doi-asserted-by":"publisher","first-page":"3197","DOI":"10.1084\/jem.20160301","article-title":"PML is a ROS sensor activating p53 upon oxidative stress","volume":"214","author":"Niwa-Kawakita","year":"2017","journal-title":"J. Exp. Med."},{"key":"2024011816270812200_bib86","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.canlet.2012.04.013","article-title":"Up-regulation of endogenous PML induced by a combination of interferon-beta and temozolomide enhances p73\/YAP-mediated apoptosis in glioblastoma","volume":"323","author":"Okazaki","year":"2012","journal-title":"Cancer Lett."},{"key":"2024011816270812200_bib87","doi-asserted-by":"publisher","first-page":"696234","DOI":"10.3389\/fcell.2021.696234","article-title":"A tale of usurpation and subversion: SUMO-dependent integrity of promyelocytic leukemia nuclear bodies at the crossroad of infection and immunity","volume":"9","author":"Patra","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"2024011816270812200_bib88","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/35018127","article-title":"PML regulates p53 acetylation and premature senescence induced by oncogenic Ras","volume":"406","author":"Pearson","year":"2000","journal-title":"Nature"},{"key":"2024011816270812200_bib89","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.molcel.2015.08.001","article-title":"MAPL SUMOylation of Drp1 stabilizes an ER\/mitochondrial platform required for cell death","volume":"59","author":"Prudent","year":"2015","journal-title":"Mol. Cell"},{"key":"2024011816270812200_bib90","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/3068","article-title":"PML induces a novel caspase-independent death process","volume":"20","author":"Quignon","year":"1998","journal-title":"Nat. Genet."},{"key":"2024011816270812200_bib91","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1016\/j.celrep.2014.11.004","article-title":"DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia","volume":"9","author":"Rampal","year":"2014","journal-title":"Cell Rep."},{"key":"2024011816270812200_bib92","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1084\/jem.193.4.521","article-title":"Role of promyelocytic leukemia (PML) protein in tumor suppression","volume":"193","author":"Rego","year":"2001","journal-title":"J. Exp. Med."},{"key":"2024011816270812200_bib93","doi-asserted-by":"publisher","first-page":"4187","DOI":"10.1038\/ncomms5187","article-title":"Interferon controls SUMO availability via the Lin28 and let-7 axis to impede virus replication","volume":"5","author":"Sahin","year":"2014","journal-title":"Nat. Commun."},{"key":"2024011816270812200_bib94","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1083\/jcb.201305148","article-title":"Oxidative stress-induced assembly of PML nuclear bodies controls sumoylation of partner proteins","volume":"204","author":"Sahin","year":"2014","journal-title":"J. Cell Biol."},{"key":"2024011816270812200_bib95","doi-asserted-by":"publisher","first-page":"3686","DOI":"10.1182\/blood-2004-09-3782","article-title":"The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage","volume":"105","author":"Salomoni","year":"2005","journal-title":"Blood"},{"key":"2024011816270812200_bib96","doi-asserted-by":"publisher","first-page":"45038","DOI":"10.1038\/srep45038","article-title":"PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4","volume":"7","author":"Salsman","year":"2017","journal-title":"Sci. Rep."},{"key":"2024011816270812200_bib97","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016598","article-title":"The herpesvirus associated ubiquitin specific protease, USP7, is a negative regulator of PML proteins and PML nuclear bodies","volume":"6","author":"Sarkari","year":"2011","journal-title":"PLoS One"},{"key":"2024011816270812200_bib98","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.cell.2006.05.041","article-title":"A CK2-dependent mechanism for degradation of the PML tumor suppressor","volume":"126","author":"Scaglioni","year":"2006","journal-title":"Cell"},{"key":"2024011816270812200_bib99","doi-asserted-by":"publisher","first-page":"5850","DOI":"10.1128\/JVI.01979-15","article-title":"Emerging role of PML nuclear bodies in innate immune signaling","volume":"90","author":"Scherer","year":"2016","journal-title":"J. Virol."},{"key":"2024011816270812200_bib100","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1158\/1535-7163.MCT-07-0515","article-title":"UBE1L represses PML\/RAR{alpha} by targeting the PML domain for ISG15ylation","volume":"7","author":"Shah","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"2024011816270812200_bib101","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.molcel.2006.09.013","article-title":"The mechanisms of PML-nuclear body formation","volume":"24","author":"Shen","year":"2006","journal-title":"Mol. Cell"},{"key":"2024011816270812200_bib102","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1038\/nm.3708","article-title":"Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy","volume":"20","author":"Sistigu","year":"2014","journal-title":"Nat. Med."},{"key":"2024011816270812200_bib103","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1158\/0008-5472.CAN-17-3091","article-title":"PML recruits TET2 to regulate DNA modification and cell proliferation in response to chemotherapeutic agent","volume":"78","author":"Song","year":"2018","journal-title":"Cancer Res."},{"key":"2024011816270812200_bib104","first-page":"2565","article-title":"Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element","volume":"11","author":"Stadler","year":"1995","journal-title":"Oncogene"},{"key":"2024011816270812200_bib105","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1038\/ncb1716","article-title":"RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation","volume":"10","author":"Tatham","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"2024011816270812200_bib106","doi-asserted-by":"publisher","first-page":"5726","DOI":"10.1038\/s41467-022-33147-6","article-title":"Exploration of nuclear body-enhanced sumoylation reveals that PML represses 2-cell features of embryonic stem cells","volume":"13","author":"Tessier","year":"2022","journal-title":"Nat. Commun."},{"key":"2024011816270812200_bib107","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/nature04809","article-title":"Identification of a tumour suppressor network opposing nuclear Akt function","volume":"441","author":"Trotman","year":"2006","journal-title":"Nature"},{"key":"2024011816270812200_bib108","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.tibs.2022.02.002","article-title":"PML isoforms: A molecular basis for PML pleiotropic functions","volume":"47","author":"Ugg\u00e8","year":"2022","journal-title":"Trends Biochem. Sci."},{"key":"2024011816270812200_bib109","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1101\/gad.1975111","article-title":"Regulation of E2Fs and senescence by PML nuclear bodies","volume":"25","author":"Vernier","year":"2011","journal-title":"Genes Dev."},{"key":"2024011816270812200_bib110","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.molcel.2014.12.023","article-title":"WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation","volume":"57","author":"Wang","year":"2015","journal-title":"Mol. Cell"},{"key":"2024011816270812200_bib111","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/3073","article-title":"PML is essential for multiple apoptotic pathways","volume":"20","author":"Wang","year":"1998","journal-title":"Nat. Genet."},{"key":"2024011816270812200_bib112","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1242\/jcs.031922","article-title":"Dynamics of component exchange at PML nuclear bodies","volume":"121","author":"Weidtkamp-Peters","year":"2008","journal-title":"J. Cell Sci."},{"key":"2024011816270812200_bib113","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1182\/blood-2011-10-387647","article-title":"E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis","volume":"120","author":"Wolyniec","year":"2012","journal-title":"Blood"},{"key":"2024011816270812200_bib114","doi-asserted-by":"publisher","first-page":"3214","DOI":"10.1038\/ncomms4214","article-title":"USP11 regulates PML stability to control Notch-induced malignancy in brain tumours","volume":"5","author":"Wu","year":"2014","journal-title":"Nat. Commun."},{"key":"2024011816270812200_bib115","doi-asserted-by":"publisher","first-page":"3198","DOI":"10.1158\/2159-8290.CD-21-0177","article-title":"Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy","volume":"11","author":"Wu","year":"2021","journal-title":"Cancer Discov."},{"key":"2024011816270812200_bib116","doi-asserted-by":"publisher","first-page":"26645","DOI":"10.1074\/jbc.M604391200","article-title":"Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation","volume":"281","author":"Yang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2024011816270812200_bib117","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1111\/j.1474-9726.2008.00411.x","article-title":"Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts","volume":"7","author":"Yates","year":"2008","journal-title":"Aging Cell"},{"key":"2024011816270812200_bib118","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.ccr.2011.07.008","article-title":"A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression","volume":"20","author":"Yuan","year":"2011","journal-title":"Cancer Cell"},{"key":"2024011816270812200_bib119","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1038\/s41375-018-0338-z","article-title":"The genetics and clinical characteristics of children morphologically diagnosed as acute promyelocytic leukemia","volume":"33","author":"Zhao","year":"2019","journal-title":"Leukemia"},{"key":"2024011816270812200_bib120","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1182\/blood.2019000760","article-title":"The simpler, the better: Oral arsenic for acute promyelocytic leukemia","volume":"134","author":"Zhu","year":"2019","journal-title":"Blood"},{"key":"2024011816270812200_bib121","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1056\/NEJMc1316382","article-title":"Resistance to arsenic therapy in acute promyelocytic leukemia","volume":"370","author":"Zhu","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"2024011816270812200_bib122","doi-asserted-by":"publisher","first-page":"3978","DOI":"10.1073\/pnas.94.8.3978","article-title":"Arsenic-induced PML targeting onto nuclear bodies: Implications for the treatment of acute promyelocytic leukemia","volume":"94","author":"Zhu","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20221213\/1923012\/jem_20221213.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20221213\/1923012\/jem_20221213.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T11:27:24Z","timestamp":1705577244000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/220\/8\/e20221213\/214198\/The-PML-hub-An-emerging-actor-of-leukemia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,29]]},"references-count":122,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8,7]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20221213","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,29]]},"article-number":"e20221213"}}