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In their work, Valencia et al. (2022. J. Exp. Med.https:\/\/doi.org\/10.1084\/jem.20220726) identify the DSTYK kinase as a cancer cell\u2013intrinsic modulator of response to immunotherapy. Through regulation of the mTOR pathway and stimulation of protective autophagy, DSTYK blunts CD8+ T cell\u2013mediated killing of cancer cells. Accordingly, lung cancers with increased expression of DSTYK are less responsive to ICI treatment. 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