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However, the properties of human macrophages in non-diseased tissues remain poorly understood. Here, we characterized human tonsil macrophages and identified three subsets with distinct phenotype, transcriptome, life cycle, and function. CD36hi macrophages were related to monocytes, while CD36lo macrophages showed features of embryonic origin and CD36int macrophages had a mixed profile. scRNA-seq on non-human primate tonsils showed that monocyte recruitment did not pre-exist an immune challenge. Functionally, CD36hi macrophages were specialized for stimulating T follicular helper cells, by producing Activin A. Combining reconstruction of ligand\u2013receptor interactions and functional assays, we identified stromal cell\u2013derived TNF-\u03b1 as an inducer of Activin A secretion. However, only CD36hi macrophages were primed for Activin A expression, via the activity of IRF1. Our results provide insight into the heterogeneity of human lymphoid organ macrophages and show that tonsil CD36hi macrophage specialization is the result of both intrinsic features and interaction with stromal cells.<\/jats:p>","DOI":"10.1084\/jem.20230002","type":"journal-article","created":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T02:20:45Z","timestamp":1679106045000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Functional specialization of short-lived and long-lived macrophage subsets in human tonsils"],"prefix":"10.1084","volume":"220","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7043-9972","authenticated-orcid":true,"given":"Lamine","family":"Alaoui","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04t0gwh46","id-type":"ROR","asserted-by":"publisher"}],"name":"1 , Paris, France"},{"name":"Institut Curie, 1 , Paris, France"},{"name":"PSL Research University, 1 , Paris, 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