{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:06:06Z","timestamp":1785513966673,"version":"3.56.0"},"reference-count":42,"publisher":"Rockefeller University Press","issue":"5","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"KWF Dutch Cancer Society","award":["10208"],"award-info":[{"award-number":["10208"]}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigacion y Desarrollo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Doctorado Becas Chile","award":["2016-72170683"],"award-info":[{"award-number":["2016-72170683"]}]},{"DOI":"10.13039\/501100009553","name":"Czech Health Research Council","doi-asserted-by":"publisher","award":["AZV NV18-03-00117"],"award-info":[{"award-number":["AZV NV18-03-00117"]}],"id":[{"id":"10.13039\/501100009553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016287","name":"Charles University in Prague","doi-asserted-by":"publisher","award":["PRIMUS\/17\/MED\/9"],"award-info":[{"award-number":["PRIMUS\/17\/MED\/9"]}],"id":[{"id":"10.13039\/100016287","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016287","name":"Charles University in Prague","doi-asserted-by":"publisher","award":["UNCE\/MED\/016"],"award-info":[{"award-number":["UNCE\/MED\/016"]}],"id":[{"id":"10.13039\/100016287","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute for Cancer Research","award":["LX22NPO5102"],"award-info":[{"award-number":["LX22NPO5102"]}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5,6]]},"abstract":"<jats:p>Diffuse large B cell lymphoma of activated B cell type (ABC-DLBCL), a major cell-of-origin DLBCL subtype, is characterized by chronic active B cell receptor (BCR) signaling and NF-\u03baB activation, which can be explained by activating mutations of the BCR signaling cascade in a minority of cases. We demonstrate that autonomous BCR signaling, akin to its essential pathogenetic role in chronic lymphocytic leukemia (CLL), can explain chronic active BCR signaling in ABC-DLBCL. 13 of 18 tested DLBCL-derived BCR, including 12 cases selected for expression of IgM, induced spontaneous calcium flux and increased phosphorylation of the BCR signaling cascade in murine triple knockout pre-B cells without antigenic stimulation or external BCR crosslinking. Autonomous BCR signaling was associated with IgM isotype, dependent on somatic BCR mutations and individual HCDR3 sequences, and largely restricted to non-GCB DLBCL. Autonomous BCR signaling represents a novel immunological oncogenic driver mechanism in DLBCL originating from individual BCR sequences and adds a new dimension to currently proposed genetics- and transcriptomics-based DLBCL classifications.<\/jats:p>","DOI":"10.1084\/jem.20230941","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T02:21:27Z","timestamp":1709605287000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL"],"prefix":"10.1084","volume":"221","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7015-9751","authenticated-orcid":true,"given":"Janneke A.","family":"Eken","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05xvt9f17","id-type":"ROR","asserted-by":"publisher"}],"name":"Leiden University Medical Center 1 Department of Hematology, , Leiden,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6993-4616","authenticated-orcid":true,"given":"Marvyn T.","family":"Koning","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05xvt9f17","id-type":"ROR","asserted-by":"publisher"}],"name":"Leiden University Medical Center 1 Department of Hematology, , Leiden,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4913-9877","authenticated-orcid":true,"given":"Kristyna","family":"Kupcova","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024d6js02","id-type":"ROR","asserted-by":"publisher"}],"name":"BIOCEV, First Faculty of Medicine, Charles University 2 , Prague,","place":["Czech Republic"]},{"id":[{"id":"https:\/\/ror.org\/024d6js02","id-type":"ROR","asserted-by":"publisher"}],"name":"General University Hospital and First Faculty of Medicine, Charles University 3 First Department of Internal Medicine\u2014Hematology, , Prague,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6354-3609","authenticated-orcid":true,"given":"Julieta H.","family":"Sep\u00falveda Y\u00e1\u00f1ez","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05xvt9f17","id-type":"ROR","asserted-by":"publisher"}],"name":"Leiden University Medical Center 1 Department of Hematology, , Leiden,","place":["Netherlands"]},{"id":[{"id":"https:\/\/ror.org\/049784n50","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Medicine, Universidad de Magallanes 4 , Punta Arenas,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2998-2066","authenticated-orcid":true,"given":"Ruben A.L.","family":"de Groen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05xvt9f17","id-type":"ROR","asserted-by":"publisher"}],"name":"Leiden University Medical Center 1 Department of Hematology, , Leiden,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9470-9683","authenticated-orcid":true,"given":"Edwin","family":"Quinten","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05xvt9f17","id-type":"ROR","asserted-by":"publisher"}],"name":"Leiden University Medical Center 1 Department of Hematology, , Leiden,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2536-7864","authenticated-orcid":true,"given":"Jurriaan","family":"Janssen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05grdyy37","id-type":"ROR","asserted-by":"publisher"}],"name":"Amsterdam University Medical Center 5 Department of Pathology, , Amsterdam,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6386-4517","authenticated-orcid":true,"given":"Cornelis A.M.","family":"van Bergen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05xvt9f17","id-type":"ROR","asserted-by":"publisher"}],"name":"Leiden University Medical Center 1 Department of Hematology, , Leiden,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1628-6256","authenticated-orcid":true,"given":"Joost S.P.","family":"Vermaat","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05xvt9f17","id-type":"ROR","asserted-by":"publisher"}],"name":"Leiden University Medical Center 1 Department of Hematology, , Leiden,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3672-4348","authenticated-orcid":true,"given":"Arjen","family":"Cleven","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05xvt9f17","id-type":"ROR","asserted-by":"publisher"}],"name":"Leiden University Medical Center 6 Department of Pathology, , Leiden,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2044-9548","authenticated-orcid":true,"given":"Marcelo A.","family":"Navarrete","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/049784n50","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Medicine, Universidad de Magallanes 4 , Punta Arenas,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9479-3010","authenticated-orcid":true,"given":"Bauke","family":"Ylstra","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05grdyy37","id-type":"ROR","asserted-by":"publisher"}],"name":"Amsterdam University Medical Center 5 Department of Pathology, , Amsterdam,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9725-4060","authenticated-orcid":true,"given":"Daphne","family":"de Jong","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05grdyy37","id-type":"ROR","asserted-by":"publisher"}],"name":"Amsterdam University Medical Center 5 Department of Pathology, , Amsterdam,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5826-3557","authenticated-orcid":true,"given":"Ondrej","family":"Havranek","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024d6js02","id-type":"ROR","asserted-by":"publisher"}],"name":"BIOCEV, First Faculty of Medicine, Charles University 2 , Prague,","place":["Czech Republic"]},{"id":[{"id":"https:\/\/ror.org\/024d6js02","id-type":"ROR","asserted-by":"publisher"}],"name":"General University Hospital and First Faculty of Medicine, Charles University 3 First Department of Internal Medicine\u2014Hematology, , Prague,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3383-141X","authenticated-orcid":true,"given":"Hassan","family":"Jumaa","sequence":"additional","affiliation":[{"name":"Institute of Immunology, University of Ulm 7 , Ulm,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9108-3125","authenticated-orcid":true,"given":"Hendrik","family":"Veelken","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05xvt9f17","id-type":"ROR","asserted-by":"publisher"}],"name":"Leiden University Medical Center 1 Department of Hematology, , Leiden,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"2025081814164703800_bib1","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms","volume":"36","author":"Alaggio","year":"2022","journal-title":"Leukemia"},{"key":"2025081814164703800_bib2","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/35000501","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling","volume":"403","author":"Alizadeh","year":"2000","journal-title":"Nature"},{"key":"2025081814164703800_bib3","doi-asserted-by":"publisher","first-page":"3361","DOI":"10.1038\/s41467-021-23695-8","article-title":"Robust detection of translocations in lymphoma FFPE samples using targeted locus capture-based sequencing","volume":"12","author":"Allahyar","year":"2021","journal-title":"Nat. Commun."},{"key":"2025081814164703800_bib4","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/bjc.2012.272","article-title":"PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma","volume":"107","author":"Brault","year":"2012","journal-title":"Br. J. Cancer"},{"key":"2025081814164703800_bib5","doi-asserted-by":"publisher","first-page":"W503","DOI":"10.1093\/nar\/gkn316","article-title":"IMGT\/V-QUEST: The highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis","volume":"36","author":"Brochet","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"2025081814164703800_bib6","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1182\/blood.2022015851","article-title":"The international consensus classification of mature lymphoid neoplasms: A report from the clinical advisory committee","volume":"140","author":"Campo","year":"2022","journal-title":"Blood"},{"key":"2025081814164703800_bib7","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/s41591-018-0016-8","article-title":"Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes","volume":"24","author":"Chapuy","year":"2018","journal-title":"Nat. Med."},{"key":"2025081814164703800_bib8","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1084\/jem.194.12.1861","article-title":"Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells","volume":"194","author":"Davis","year":"2001","journal-title":"J. Exp. Med."},{"key":"2025081814164703800_bib9","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nature08638","article-title":"Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma","volume":"463","author":"Davis","year":"2010","journal-title":"Nature"},{"key":"2025081814164703800_bib10","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nature11309","article-title":"Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling","volume":"489","author":"D\u00fchren-von Minden","year":"2012","journal-title":"Nature"},{"key":"2025081814164703800_bib11","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.1093\/bioinformatics\/btw354","article-title":"MultiQC: Summarize analysis results for multiple tools and samples in a single report","volume":"32","author":"Ewels","year":"2016","journal-title":"Bioinformatics"},{"key":"2025081814164703800_bib12","doi-asserted-by":"publisher","first-page":"63","DOI":"10.12688\/f1000research.16665.2","article-title":"Sarek: A portable workflow for whole-genome sequencing analysis of germline and somatic variants","volume":"9","author":"Garcia","year":"2020","journal-title":"F1000 Res."},{"key":"2025081814164703800_bib13","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1182\/blood-2003-05-1545","article-title":"Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray","volume":"103","author":"Hans","year":"2004","journal-title":"Blood"},{"key":"2025081814164703800_bib14","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1182\/blood-2016-10-747303","article-title":"Tonic B-cell receptor signaling in diffuse large B-cell lymphoma","volume":"130","author":"Havranek","year":"2017","journal-title":"Blood"},{"key":"2025081814164703800_bib15","doi-asserted-by":"publisher","first-page":"3326","DOI":"10.1002\/cncr.30739","article-title":"Cancer-specific mortality, cure fraction, and noncancer causes of death among diffuse large B-cell lymphoma patients in the immunochemotherapy era","volume":"123","author":"Howlader","year":"2017","journal-title":"Cancer"},{"key":"2025081814164703800_bib16","doi-asserted-by":"publisher","first-page":"D587","DOI":"10.1093\/nar\/gkac963","article-title":"KEGG for taxonomy-based analysis of pathways and genomes","volume":"51","author":"Kanehisa","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"2025081814164703800_bib17","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/s41592-018-0051-x","article-title":"Strelka2: Fast and accurate calling of germline and somatic variants","volume":"15","author":"Kim","year":"2018","journal-title":"Nat. Methods"},{"key":"2025081814164703800_bib18","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1111\/bjh.14180","article-title":"ARTISAN PCR: Rapid identification of full-length immunoglobulin rearrangements without primer binding bias","volume":"178","author":"Koning","year":"2017","journal-title":"Br. J. Haematol."},{"key":"2025081814164703800_bib19","first-page":"2489","article-title":"The role of PIM1 in the ibrutinib-resistant ABC subtype of diffuse large B-cell lymphoma","volume":"6","author":"Kuo","year":"2016","journal-title":"Am. J. Cancer Res."},{"key":"2025081814164703800_bib20","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1126\/science.1153629","article-title":"Oncogenic CARD11 mutations in human diffuse large B cell lymphoma","volume":"319","author":"Lenz","year":"2008","journal-title":"Science"},{"key":"2025081814164703800_bib21","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"2025081814164703800_bib22","doi-asserted-by":"publisher","first-page":"4320","DOI":"10.1073\/pnas.1913810117","article-title":"IGLV3-21*01 Is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling","volume":"117","author":"Maity","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025081814164703800_bib23","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The genome analysis toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res."},{"key":"2025081814164703800_bib24","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1093\/bioinformatics\/btq330","article-title":"Deriving the consequences of genomic variants with the Ensembl API and SNP effect predictor","volume":"26","author":"McLaren","year":"2010","journal-title":"Bioinformatics"},{"key":"2025081814164703800_bib25","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.immuni.2007.01.012","article-title":"Conventional light chains inhibit the autonomous signaling capacity of the B cell receptor","volume":"26","author":"Meixlsperger","year":"2007","journal-title":"Immunity"},{"key":"2025081814164703800_bib26","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1038\/s41375-022-01670-6","article-title":"A bioinformatics perspective on molecular classification of diffuse large B-cell lymphoma","volume":"36","author":"Mendeville","year":"2022","journal-title":"Leukemia"},{"key":"2025081814164703800_bib27","doi-asserted-by":"publisher","first-page":"15746","DOI":"10.1038\/ncomms15746","article-title":"Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia","volume":"8","author":"Minici","year":"2017","journal-title":"Nat. Commun."},{"key":"2025081814164703800_bib28","doi-asserted-by":"publisher","first-page":"5701","DOI":"10.1128\/jvi.70.8.5701-5705.1996","article-title":"The pCL vector system: Rapid production of helper-free, high-titer, recombinant retroviruses","volume":"70","author":"Naviaux","year":"1996","journal-title":"J. Virol."},{"key":"2025081814164703800_bib29","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/nature09671","article-title":"Oncogenically active MYD88 mutations in human lymphoma","volume":"470","author":"Ngo","year":"2011","journal-title":"Nature"},{"key":"2025081814164703800_bib30","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41586-018-0290-0","article-title":"A multiprotein supercomplex controlling oncogenic signalling in lymphoma","volume":"560","author":"Phelan","year":"2018","journal-title":"Nature"},{"key":"2025081814164703800_bib31","doi-asserted-by":"publisher","first-page":"824","DOI":"10.3324\/haematol.2022.282542","article-title":"Autonomous B-cell receptor signaling and genetic aberrations in chronic lymphocytic leukemia-phenotype monoclonal B lymphocytosis in siblings of patients with chronic lymphocytic leukemia","volume":"109","author":"Quinten","year":"2023","journal-title":"Haematologica"},{"key":"2025081814164703800_bib32","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.cell.2017.09.027","article-title":"Genetic and functional drivers of diffuse large B Cell lymphoma","volume":"171","author":"Reddy","year":"2017","journal-title":"Cell"},{"key":"2025081814164703800_bib33","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1056\/NEJMoa012914","article-title":"The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma","volume":"346","author":"Rosenwald","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"2025081814164703800_bib42","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/leu.2010.302","article-title":"The isotype of the BCR as a surrogate for the GCB and ABC molecular subtypes in diffuse large B-cell lymphoma","volume":"25","author":"Ruminy","year":"2011","journal-title":"Leukemia"},{"key":"2025081814164703800_bib34","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1056\/NEJMoa1801445","article-title":"Genetics and pathogenesis of diffuse large B-cell lymphoma","volume":"378","author":"Schmitz","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"2025081814164703800_bib35","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1182\/blood-2013-11-536433","article-title":"Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue","volume":"123","author":"Scott","year":"2014","journal-title":"Blood"},{"key":"2025081814164703800_bib36","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1002\/eji.200636667","article-title":"The Ig-alpha ITAM is required for efficient differentiation but not proliferation of pre-B cells","volume":"37","author":"Storch","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"2025081814164703800_bib37","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.3324\/haematol.2019.241653","article-title":"Identification of the atypically modified autoantigen Ars2 as the target of B-cell receptors from activated B-cell-type diffuse large B-cell lymphoma","volume":"106","author":"Thurner","year":"2021","journal-title":"Haematologica"},{"key":"2025081814164703800_bib38","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1016\/j.ccell.2021.10.006","article-title":"Effect of ibrutinib with R-CHOP chemotherapy in genetic subtypes of DLBCL","volume":"39","author":"Wilson","year":"2021","journal-title":"Cancer Cell"},{"key":"2025081814164703800_bib39","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1038\/nm.3884","article-title":"Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma","volume":"21","author":"Wilson","year":"2015","journal-title":"Nat. Med."},{"key":"2025081814164703800_bib40","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.ccell.2020.03.015","article-title":"A probabilistic classification tool for genetic subtypes of diffuse large B cell lymphoma with therapeutic implications","volume":"37","author":"Wright","year":"2020","journal-title":"Cancer Cell"},{"key":"2025081814164703800_bib41","doi-asserted-by":"publisher","first-page":"13447","DOI":"10.1073\/pnas.1514944112","article-title":"Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens","volume":"112","author":"Young","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20230941\/1926183\/jem_20230941.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20230941\/1926183\/jem_20230941.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T18:16:54Z","timestamp":1755541014000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/221\/5\/e20230941\/276647\/Antigen-independent-autonomous-B-cell-receptor"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,21]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5,6]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20230941","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,21]]},"article-number":"e20230941"}}