{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:03:31Z","timestamp":1785409411383,"version":"3.56.0"},"reference-count":91,"publisher":"Rockefeller University Press","issue":"9","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["57-B28"],"award-info":[{"award-number":["57-B28"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["V 1025-B"],"award-info":[{"award-number":["V 1025-B"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["DOC32-B28"],"award-info":[{"award-number":["DOC32-B28"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["F8007"],"award-info":[{"award-number":["F8007"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P32678"],"award-info":[{"award-number":["P32678"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005788","name":"Medical University of Vienna","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:p>Patho-mechanistic origins of ulcerative colitis are still poorly understood. The actin cross-linker filamin A (FLNA) impacts cellular responses through interaction with cytosolic proteins. Posttranscriptional A-to-I editing generates two forms of FLNA: genome-encoded FLNAQ and FLNAR. FLNA is edited in colon fibroblasts, smooth muscle cells, and endothelial cells. We found that the FLNA editing status determines colitis severity. Editing was highest in healthy colons and reduced during murine and human colitis. Mice that exclusively express FLNAR were highly resistant to DSS-induced colitis, whereas fully FLNAQ animals developed severe inflammation. While the genetic induction of FLNA editing influenced transcriptional states of structural cells and microbiome composition, we found that FLNAR exerts protection specifically via myeloid cells, which are physiologically unedited. Introducing fixed FLNAR did not hamper cell migration but reduced macrophage inflammation and rendered neutrophils less prone to NETosis. Thus, loss of FLNA editing correlates with colitis severity, and targeted editing of myeloid cells serves as a novel therapeutic approach in intestinal inflammation.<\/jats:p>","DOI":"10.1084\/jem.20240109","type":"journal-article","created":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T02:20:47Z","timestamp":1747448447000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Filamin A editing in myeloid cells reduces intestinal inflammation and protects from colitis"],"prefix":"10.1084","volume":"222","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4267-2131","authenticated-orcid":true,"given":"Riem","family":"Gawish","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05n3x4p02","id-type":"ROR","asserted-by":"publisher"}],"name":"Center of Anatomy and Cell Biology, Division of Cell and Developmental Biology, Medical University of Vienna 1 , Vienna,","place":["Austria"]},{"id":[{"id":"https:\/\/ror.org\/05n3x4p02","id-type":"ROR","asserted-by":"publisher"}],"name":"Medical University of Vienna 2 Department of Medicine I, Research Division of Infection Biology, , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6740-6564","authenticated-orcid":true,"given":"Rajagopal","family":"Varada","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05n3x4p02","id-type":"ROR","asserted-by":"publisher"}],"name":"Center of Anatomy and Cell Biology, Division of Cell and Developmental Biology, Medical University of Vienna 1 , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3075-6808","authenticated-orcid":true,"given":"Florian","family":"Deckert","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05n3x4p02","id-type":"ROR","asserted-by":"publisher"}],"name":"Medical University of Vienna 2 Department of Medicine I, Research Division of Infection Biology, , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7054-6567","authenticated-orcid":true,"given":"Anastasiya","family":"Hladik","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05n3x4p02","id-type":"ROR","asserted-by":"publisher"}],"name":"Medical University of Vienna 2 Department of Medicine I, Research Division of Infection Biology, , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7675-7631","authenticated-orcid":true,"given":"Linda","family":"Steinbichl","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05n3x4p02","id-type":"ROR","asserted-by":"publisher"}],"name":"Center of Anatomy and Cell Biology, Division of Cell and Developmental Biology, Medical University of Vienna 1 , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5396-9603","authenticated-orcid":true,"given":"Laura","family":"Cimatti","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05n3x4p02","id-type":"ROR","asserted-by":"publisher"}],"name":"Center of Anatomy and Cell Biology, Division of Cell and Developmental Biology, Medical University of Vienna 1 , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1594-4440","authenticated-orcid":true,"given":"Katarina","family":"Milanovic","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05n3x4p02","id-type":"ROR","asserted-by":"publisher"}],"name":"Center of Anatomy and Cell Biology, Division of Cell and Developmental Biology, Medical University of Vienna 1 , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-7783","authenticated-orcid":true,"given":"Mamta","family":"Jain","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05n3x4p02","id-type":"ROR","asserted-by":"publisher"}],"name":"Center of Anatomy and Cell Biology, Division of Cell and Developmental Biology, Medical University of Vienna 1 , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1458-2956","authenticated-orcid":true,"given":"Natalya","family":"Torgasheva","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05n3x4p02","id-type":"ROR","asserted-by":"publisher"}],"name":"Center of Anatomy and Cell Biology, Division of Cell and Developmental Biology, Medical University of Vienna 1 , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2873-4236","authenticated-orcid":true,"given":"Andrea","family":"Tanzer","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05n3x4p02","id-type":"ROR","asserted-by":"publisher"}],"name":"Center of Anatomy and Cell Biology, Division of Cell and Developmental Biology, Medical University of Vienna 1 , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7948-6765","authenticated-orcid":true,"given":"Kim","family":"De Paepe","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cv9y106","id-type":"ROR","asserted-by":"publisher"}],"name":"Ghent University, Center for Microbial Ecology and Technology 4 Department of Biotechnology, , Ghent,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6854-5689","authenticated-orcid":true,"given":"Tom","family":"Van de Wiele","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cv9y106","id-type":"ROR","asserted-by":"publisher"}],"name":"Ghent University, Center for Microbial Ecology and Technology 4 Department of Biotechnology, , Ghent,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0846-1202","authenticated-orcid":true,"given":"Bela","family":"Hausmann","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03prydq77","id-type":"ROR","asserted-by":"publisher"}],"name":"Joint Microbiome Facility of the Medical University of Vienna and the University of Vienna 5 , Vienna,","place":["Austria"]},{"id":[{"id":"https:\/\/ror.org\/05n3x4p02","id-type":"ROR","asserted-by":"publisher"}],"name":"Medical University of Vienna 6 Division of Clinical Microbiology, Department of Laboratory Medicine, , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8444-3719","authenticated-orcid":true,"given":"Michaela","family":"Lang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03prydq77","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Vienna, Center for Microbiology and Environmental Systems Science 3 Department of Microbiology and Ecosystem Science, , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6227-6143","authenticated-orcid":true,"given":"Martin","family":"Pechhacker","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05n3x4p02","id-type":"ROR","asserted-by":"publisher"}],"name":"Center of Anatomy and Cell Biology, Division of Cell and Developmental Biology, Medical University of Vienna 1 , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2083-9175","authenticated-orcid":true,"given":"Nahla","family":"Ibrahim","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05n3x4p02","id-type":"ROR","asserted-by":"publisher"}],"name":"Medical University of Vienna 7 Division of Vascular Surgery, Department of General Surgery, , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3235-1264","authenticated-orcid":true,"given":"Ingrid","family":"De Vries","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03gnh5541","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Science and Technology Austria 8 , Klosterneuburg,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1462-5397","authenticated-orcid":true,"given":"Christine","family":"Brostjan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05n3x4p02","id-type":"ROR","asserted-by":"publisher"}],"name":"Medical University of Vienna 7 Division of Vascular Surgery, Department of General Surgery, , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6620-9179","authenticated-orcid":true,"given":"Michael","family":"Sixt","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03gnh5541","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Science and Technology Austria 8 , Klosterneuburg,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3752-6685","authenticated-orcid":true,"given":"Christoph","family":"Gasche","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05n3x4p02","id-type":"ROR","asserted-by":"publisher"}],"name":"Medical University of Vienna 9 Department of Medicine III, Division of Gastroenterology and Hepatology, , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0937-9171","authenticated-orcid":true,"given":"Louis","family":"Boon","sequence":"additional","affiliation":[{"name":"JJP Biologics 10 , Warsaw,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8997-608X","authenticated-orcid":true,"given":"David","family":"Berry","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03prydq77","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Vienna, Center for Microbiology and Environmental Systems Science 3 Department of Microbiology and Ecosystem Science, , Vienna,","place":["Austria"]},{"id":[{"id":"https:\/\/ror.org\/03prydq77","id-type":"ROR","asserted-by":"publisher"}],"name":"Joint Microbiome Facility of the Medical University of Vienna and the University of Vienna 5 , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1747-0853","authenticated-orcid":true,"given":"Michael F.","family":"Jantsch","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05n3x4p02","id-type":"ROR","asserted-by":"publisher"}],"name":"Center of Anatomy and Cell Biology, Division of Cell and Developmental Biology, Medical University of Vienna 1 , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1288-6481","authenticated-orcid":true,"given":"Fatima C.","family":"Pereira","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03prydq77","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Vienna, Center for Microbiology and Environmental Systems Science 3 Department of Microbiology and Ecosystem Science, , Vienna,","place":["Austria"]},{"name":"University of Southampton 11 School of Biological Sciences, Faculty for Environmental and Life Sciences, , Southampton,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2463-9223","authenticated-orcid":true,"given":"Cornelia","family":"Vesely","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05n3x4p02","id-type":"ROR","asserted-by":"publisher"}],"name":"Center of Anatomy and Cell Biology, Division of Cell and Developmental Biology, Medical University of Vienna 1 , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"2025060509405658200_bib1","doi-asserted-by":"publisher","DOI":"10.1002\/imt2.58","article-title":"Metabolite profiling of human-originated Lachnospiraceae at the strain level","volume":"1","author":"Abdugheni","year":"2022","journal-title":"Imeta"},{"key":"2025060509405658200_bib2","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/s41588-021-00837-8","article-title":"The sickening consequences of too much SYK signaling","volume":"53","author":"Aksentijevich","year":"2021","journal-title":"Nat. Genet."},{"key":"2025060509405658200_bib3","doi-asserted-by":"publisher","first-page":"5464","DOI":"10.4049\/jimmunol.166.9.5464","article-title":"Fine tuning of TCR signaling by CD5","volume":"166","author":"Azzam","year":"2001","journal-title":"J. Immunol."},{"key":"2025060509405658200_bib4","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1093\/ecco-jcc\/jjaa065","article-title":"Gut microbiota-derived propionate regulates the expression of Reg3 mucosal lectins and ameliorates experimental colitis in mice","volume":"14","author":"Bajic","year":"2020","journal-title":"J. Crohns Colitis"},{"key":"2025060509405658200_bib5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007830","article-title":"Filamins regulate cell spreading and initiation of cell migration","volume":"4","author":"Baldassarre","year":"2009","journal-title":"PLoS One"},{"key":"2025060509405658200_bib6","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1161\/CIRCULATIONAHA.119.039697","article-title":"Targeting filamin A reduces macrophage activity and atherosclerosis","volume":"140","author":"Bandaru","year":"2019","journal-title":"Circulation"},{"key":"2025060509405658200_bib7","doi-asserted-by":"publisher","first-page":"6555","DOI":"10.3390\/ijms22126555","article-title":"Filamin A regulates cardiovascular remodeling","volume":"22","author":"Bandaru","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2025060509405658200_bib8","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.1097\/MIB.0b013e3182a8759a","article-title":"Gut microbiota affects sensitivity to acute DSS-induced colitis independently of host genotype","volume":"19","author":"Brinkman","year":"2013","journal-title":"Inflamm. Bowel Dis."},{"key":"2025060509405658200_bib9","doi-asserted-by":"publisher","first-page":"4272","DOI":"10.1182\/blood-2004-12-4883","article-title":"Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2","volume":"105","author":"Buitenhuis","year":"2005","journal-title":"Blood"},{"key":"2025060509405658200_bib10","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/j.immuni.2021.06.006","article-title":"The neutrophil","volume":"54","author":"Burn","year":"2021","journal-title":"Immunity"},{"key":"2025060509405658200_bib11","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/s41586-020-2193-0","article-title":"Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells","volume":"581","author":"Campbell","year":"2020","journal-title":"Nature"},{"key":"2025060509405658200_bib12","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/s41577-019-0268-7","article-title":"Host-microbiota interactions in inflammatory bowel disease","volume":"20","author":"Caruso","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"2025060509405658200_bib13","doi-asserted-by":"publisher","first-page":"12690","DOI":"10.1074\/jbc.RA118.002404","article-title":"Regulator of G protein signaling 5 restricts neutrophil chemotaxis and trafficking","volume":"293","author":"Chan","year":"2018","journal-title":"J. Biol. Chem."},{"key":"2025060509405658200_bib14","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/s41392-023-01452-1","article-title":"Macrophages in immunoregulation and therapeutics","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"2025060509405658200_bib15","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1038\/sj.onc.1204385","article-title":"Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity","volume":"20","author":"Chinenov","year":"2001","journal-title":"Oncogene"},{"key":"2025060509405658200_bib16","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1023\/A:1008942828960","article-title":"Conditional gene targeting in macrophages and granulocytes using LysMcre mice","volume":"8","author":"Clausen","year":"1999","journal-title":"Transgenic Res."},{"key":"2025060509405658200_bib17","doi-asserted-by":"publisher","DOI":"10.4161\/21688370.2014.982426","article-title":"Roles and regulation of the mucus barrier in the gut","volume":"3","author":"Cornick","year":"2015","journal-title":"Tissue Barriers"},{"key":"2025060509405658200_bib18","doi-asserted-by":"publisher","first-page":"682614","DOI":"10.3389\/fphar.2021.682614","article-title":"Claudins: Beyond tight junctions in human IBD and murine models","volume":"12","author":"\u010cu\u017ei\u0107","year":"2021","journal-title":"Front. Pharmacol."},{"key":"2025060509405658200_bib19","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1002\/immu.200310005","article-title":"Transgenic mice with hematopoietic and lymphoid specific expression of Cre","volume":"33","author":"de Boer","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"2025060509405658200_bib20","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41423-018-0024-0","article-title":"NETosis, complement, and coagulation: A triangular relationship","volume":"16","author":"de Bont","year":"2019","journal-title":"Cell. Mol. Immunol."},{"key":"2025060509405658200_bib21","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1261\/rna.079518.122","article-title":"Site-directed A \u2192 I RNA editing as a therapeutic tool: Moving beyond genetic mutations","volume":"29","author":"Diaz Quiroz","year":"2023","journal-title":"RNA"},{"key":"2025060509405658200_bib22","doi-asserted-by":"publisher","first-page":"7365913","DOI":"10.1155\/2019\/7365913","article-title":"Myoferlin, a membrane protein with emerging oncogenic roles","volume":"2019","author":"Dong","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"2025060509405658200_bib23","doi-asserted-by":"publisher","first-page":"105779","DOI":"10.1016\/j.phrs.2021.105779","article-title":"Neutrophil extracellular traps in inflammatory bowel diseases: Implications in pathogenesis and therapeutic targets","volume":"171","author":"Dos Santos Ramos","year":"2021","journal-title":"Pharmacol. Res."},{"key":"2025060509405658200_bib24","doi-asserted-by":"publisher","first-page":"6016","DOI":"10.3748\/wjg.v23.i33.6016","article-title":"Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis","volume":"23","author":"Eichele","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"2025060509405658200_bib25","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1186\/s12885-022-10097-2","article-title":"Pyroptosis related genes signature predicts prognosis and immune infiltration of tumor microenvironment in hepatocellular carcinoma","volume":"22","author":"Fang","year":"2022","journal-title":"BMC Cancer"},{"key":"2025060509405658200_bib26","doi-asserted-by":"publisher","first-page":"19836","DOI":"10.1073\/pnas.0609628104","article-title":"Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis","volume":"103","author":"Feng","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025060509405658200_bib27","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1038\/s41467-022-28841-4","article-title":"Landscape of adenosine-to-inosine RNA recoding across human tissues","volume":"13","author":"Gabay","year":"2022","journal-title":"Nat. Commun."},{"key":"2025060509405658200_bib28","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.3389\/fmicb.2018.01177","article-title":"CD100\/Sema4D increases macrophage infection by leishmania (leishmania) amazonensis in a CD72 dependent manner","volume":"9","author":"Galuppo","year":"2018","journal-title":"Front. Microbiol."},{"key":"2025060509405658200_bib29","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1086\/513321","article-title":"Filamin A is mutated in X-linked chronic idiopathic intestinal pseudo-obstruction with central nervous system involvement","volume":"80","author":"Gargiulo","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"2025060509405658200_bib30","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.74623","article-title":"ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFN\u03b3-driven immunopathology","volume":"11","author":"Gawish","year":"2022","journal-title":"Elife"},{"key":"2025060509405658200_bib31","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1002\/gene.10161","article-title":"VavCre transgenic mice: A tool for mutagenesis in hematopoietic and endothelial lineages","volume":"34","author":"Georgiades","year":"2002","journal-title":"Genesis"},{"key":"2025060509405658200_bib32","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1159\/000268161","article-title":"N-acetylcysteine amide protects renal proximal tubular epithelial cells against iohexol-induced apoptosis by blocking p38 MAPK and iNOS signaling","volume":"31","author":"Gong","year":"2010","journal-title":"Am. J. Nephrol."},{"key":"2025060509405658200_bib33","doi-asserted-by":"publisher","first-page":"13051","DOI":"10.1074\/jbc.M111.307124","article-title":"Macrophage mesenchymal migration requires podosome stabilization by filamin A","volume":"287","author":"Guiet","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2025060509405658200_bib34","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nri1862","article-title":"CCL3 and CCL4 actively recruit CD8+ T cells","volume":"6","author":"Honey","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"2025060509405658200_bib35","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.jacbts.2023.11.003","article-title":"Reducing abdominal aortic aneurysm progression by blocking neutrophil extracellular traps depends on thrombus formation","volume":"9","author":"Ibrahim","year":"2024","journal-title":"JACC Basic Transl. Sci."},{"key":"2025060509405658200_bib36","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/s41420-024-02034-y","article-title":"Human monocyte subsets differ in their capacity to form extracellular traps","volume":"10","author":"Ibrahim","year":"2024","journal-title":"Cell Death Discov."},{"key":"2025060509405658200_bib37","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.omtn.2022.11.004","article-title":"Filamin A pre-mRNA editing modulates vascularization and tumor growth","volume":"30","author":"Jain","year":"2022","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"2025060509405658200_bib38","doi-asserted-by":"publisher","first-page":"37","DOI":"10.15252\/embj.201694813","article-title":"RNA editing of Filamin A pre-mRNA regulates vascular contraction and diastolic blood pressure","volume":"37","author":"Jain","year":"2018","journal-title":"EMBO J."},{"key":"2025060509405658200_bib39","doi-asserted-by":"publisher","first-page":"4580","DOI":"10.1111\/febs.16391","article-title":"A-to-I RNA editing of Filamin A regulates cellular adhesion, migration and mechanical properties","volume":"289","author":"Jain","year":"2022","journal-title":"FEBS J."},{"key":"2025060509405658200_bib40","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/s41568-021-00339-z","article-title":"Antigen presentation in cancer: Insights into tumour immunogenicity and immune evasion","volume":"21","author":"Jhunjhunwala","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"2025060509405658200_bib41","doi-asserted-by":"publisher","first-page":"5188","DOI":"10.1111\/jcmm.13822","article-title":"The roles of TNFAIP2 in cancers and infectious diseases","volume":"22","author":"Jia","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"2025060509405658200_bib42","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"key":"2025060509405658200_bib43","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/s41596-024-01045-4","article-title":"CellChat for systematic analysis of cell-cell communication from single-cell transcriptomics","volume":"20","author":"Jin","year":"2025","journal-title":"Nat. Protoc."},{"key":"2025060509405658200_bib44","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/nature11582","article-title":"Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease","volume":"491","author":"Jostins","year":"2012","journal-title":"Nature"},{"key":"2025060509405658200_bib45","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.24437","article-title":"Diverse stimuli engage different neutrophil extracellular trap pathways","volume":"6","author":"Kenny","year":"2017","journal-title":"Elife"},{"key":"2025060509405658200_bib46","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1080\/15476286.2021.1983288","article-title":"Site-directed RNA editing: Recent advances and open challenges","volume":"18","author":"Khosravi","year":"2021","journal-title":"RNA Biol."},{"key":"2025060509405658200_bib47","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.jcmgh.2015.01.006","article-title":"Experimental models of inflammatory bowel diseases","volume":"1","author":"Kiesler","year":"2015","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"2025060509405658200_bib48","doi-asserted-by":"publisher","DOI":"10.1101\/060012","article-title":"Fast gene set enrichment analysis","author":"Korotkevich","year":"2021","journal-title":"bioRxiv"},{"key":"2025060509405658200_bib49","doi-asserted-by":"publisher","first-page":"43","DOI":"10.4292\/wjgpt.v1.i2.43","article-title":"Recent advances in the management of distal ulcerative colitis","volume":"1","author":"Koutroubakis","year":"2010","journal-title":"World J. Gastrointest. Pharmacol. Ther."},{"key":"2025060509405658200_bib50","doi-asserted-by":"publisher","first-page":"556","DOI":"10.3389\/fendo.2020.00556","article-title":"Master regulator activating transcription factor 3 (ATF3) in metabolic homeostasis and cancer","volume":"11","author":"Ku","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"2025060509405658200_bib51","doi-asserted-by":"publisher","first-page":"591323","DOI":"10.3389\/fcell.2020.591323","article-title":"Molecular tuning of filamin A activities in the context of adhesion and migration","volume":"8","author":"Lamsoul","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"2025060509405658200_bib52","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1093\/ecco-jcc\/jjz132","article-title":"Neutrophil extracellular traps induce intestinal damage and thrombotic tendency in inflammatory bowel disease","volume":"14","author":"Li","year":"2020","journal-title":"J. Crohns Colitis"},{"key":"2025060509405658200_bib53","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201948779","article-title":"Nuclear envelope rupture and NET formation is driven by PKC\u03b1-mediated lamin B disassembly","volume":"21","author":"Li","year":"2020","journal-title":"EMBO Rep."},{"key":"2025060509405658200_bib54","doi-asserted-by":"publisher","first-page":"108627","DOI":"10.1016\/j.celrep.2020.108627","article-title":"Critical role of Syk-dependent STAT1 activation in innate antiviral immunity","volume":"34","author":"Liu","year":"2021","journal-title":"Cell Rep."},{"key":"2025060509405658200_bib55","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s41592-021-01336-8","article-title":"Benchmarking atlas-level data integration in single-cell genomics","volume":"19","author":"Luecken","year":"2022","journal-title":"Nat. Methods"},{"key":"2025060509405658200_bib56","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s10565-020-09518-4","article-title":"Sodium butyrate modulates gut microbiota and immune response in colorectal cancer liver metastatic mice","volume":"36","author":"Ma","year":"2020","journal-title":"Cell Biol. Toxicol."},{"key":"2025060509405658200_bib57","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.immuni.2017.07.011","article-title":"Nlrp6- and ASC-dependent inflammasomes do not shape the commensal gut microbiota composition","volume":"47","author":"Mamantopoulos","year":"2017","journal-title":"Immunity"},{"key":"2025060509405658200_bib58","doi-asserted-by":"publisher","first-page":"160","DOI":"10.4161\/cam.5.2.14401","article-title":"The filamins: Organizers of cell structure and function","volume":"5","author":"Nakamura","year":"2011","journal-title":"Cell Adh. Migr."},{"key":"2025060509405658200_bib59","article-title":"Ulcerative colitis [Online]","author":"National Library of Medicine","year":"2023"},{"key":"2025060509405658200_bib60","doi-asserted-by":"publisher","first-page":"110710","DOI":"10.1016\/j.celrep.2022.110710","article-title":"Inflammation induces pro-NETotic neutrophils via TNFR2 signaling","volume":"39","author":"Neuenfeldt","year":"2022","journal-title":"Cell Rep."},{"key":"2025060509405658200_bib61","doi-asserted-by":"publisher","first-page":"8201","DOI":"10.1158\/0008-5472.CAN-07-6567","article-title":"The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer","volume":"68","author":"Nolan","year":"2008","journal-title":"Cancer Res."},{"key":"2025060509405658200_bib62","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1002\/JLB.3A0817-327RR","article-title":"CIRP increases ICAM-1+ phenotype of neutrophils exhibiting elevated iNOS and NETs in sepsis","volume":"103","author":"Ode","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"2025060509405658200_bib63","doi-asserted-by":"publisher","first-page":"1201500","DOI":"10.3389\/fonc.2023.1201500","article-title":"A review on lymphocyte radiosensitivity and its impact on radiotherapy","volume":"13","author":"Paganetti","year":"2023","journal-title":"Front. Oncol."},{"key":"2025060509405658200_bib64","doi-asserted-by":"publisher","first-page":"R828","DOI":"10.1016\/j.cub.2020.05.045","article-title":"Immunity: Neutrophil quorum at the wound","volume":"30","author":"Palomino-Segura","year":"2020","journal-title":"Curr. Biol."},{"key":"2025060509405658200_bib65","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1046\/j.1365-2567.1999.00809.x","article-title":"Depletion of CD8+ cells abolishes memory in acquired immunity against Chlamydia pneumoniae in BALB\/c mice","volume":"97","author":"Penttil\u00e4","year":"1999","journal-title":"Immunology"},{"key":"2025060509405658200_bib66","doi-asserted-by":"publisher","first-page":"111817","DOI":"10.1016\/j.biopha.2021.111817","article-title":"Immunomodulatory roles of microbiota-derived short-chain fatty acids in bacterial infections","volume":"141","author":"Ranjbar","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"2025060509405658200_bib67","doi-asserted-by":"publisher","DOI":"10.1172\/JCI170733","article-title":"Macrophage-endothelial cell crosstalk orchestrates neutrophil recruitment in inflamed mucosa","volume":"133","author":"Ren","year":"2023","journal-title":"J. Clin. Invest."},{"key":"2025060509405658200_bib68","article-title":"Chpater 5 - micro-engineered \u201cpillar forests\u201d to study cell migration in complex but controlled 3D environments","volume-title":"Methods in Cell Biology","author":"Renkawitz","year":"2018"},{"key":"2025060509405658200_bib69","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1016\/j.celrep.2019.04.023","article-title":"Comparison of Co-housing and littermate methods for microbiota standardization in mouse models","volume":"27","author":"Robertson","year":"2019","journal-title":"Cell Rep."},{"key":"2025060509405658200_bib70","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.ceb.2019.10.007","article-title":"Emerging roles for the nucleus during neutrophil signal relay and NETosis","volume":"62","author":"Saunders","year":"2020","journal-title":"Curr. Opin. Cell Biol."},{"key":"2025060509405658200_bib71","doi-asserted-by":"publisher","first-page":"33123","DOI":"10.1038\/srep33123","article-title":"Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions","volume":"6","author":"Sawant","year":"2016","journal-title":"Sci. Rep."},{"key":"2025060509405658200_bib72","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1146\/annurev-immunol-032713-120231","article-title":"Interferon-stimulated genes: A complex web of host defenses","volume":"32","author":"Schneider","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"2025060509405658200_bib73","doi-asserted-by":"publisher","first-page":"100738","DOI":"10.1016\/j.bbrep.2020.100738","article-title":"Regenerating islet-derived protein (Reg)3\u03b2 plays a crucial role in attenuation of ileitis and colitis in mice","volume":"21","author":"Shindo","year":"2020","journal-title":"Biochem. Biophys. Rep."},{"key":"2025060509405658200_bib74","doi-asserted-by":"publisher","first-page":"9841","DOI":"10.1038\/s41598-021-89185-5","article-title":"Cage and maternal effects on the bacterial communities of the murine gut","volume":"11","author":"Singh","year":"2021","journal-title":"Sci. Rep."},{"key":"2025060509405658200_bib75","doi-asserted-by":"publisher","first-page":"100489","DOI":"10.1016\/j.xpro.2021.100489","article-title":"Protocols for endothelial cell isolation from mouse tissues: Small intestine, colon, heart, and liver","volume":"2","author":"Sokol","year":"2021","journal-title":"STAR Protoc."},{"key":"2025060509405658200_bib76","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.4161\/rna.26216","article-title":"Spatio-temporal profiling of Filamin A RNA-editing reveals ADAR preferences and high editing levels outside neuronal tissues","volume":"10","author":"Stuli\u0107","year":"2013","journal-title":"RNA Biol."},{"key":"2025060509405658200_bib77","doi-asserted-by":"publisher","first-page":"10053","DOI":"10.3748\/wjg.v22.i45.10053","article-title":"Smoc2 potentiates proliferation of hepatocellular carcinoma cells via promotion of cell cycle progression","volume":"22","author":"Su","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"2025060509405658200_bib78","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/ni1553","article-title":"Semaphorins and their receptors in immune cell interactions","volume":"9","author":"Suzuki","year":"2008","journal-title":"Nat. Immunol."},{"key":"2025060509405658200_bib79","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1101\/gr.277686.123","article-title":"RNA Pol II-dependent transcription efficiency fine-tunes A-to-I editing levels","volume":"34","author":"Szabo","year":"2024","journal-title":"Genome Res."},{"key":"2025060509405658200_bib80","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1194\/jlr.S091280","article-title":"Inflammasomes, neutrophil extracellular traps, and cholesterol","volume":"60","author":"Tall","year":"2019","journal-title":"J. Lipid Res."},{"key":"2025060509405658200_bib81","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: Molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"2025060509405658200_bib82","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/s41419-019-2086-z","article-title":"Keep calm: The intestinal barrier at the interface of peace and war","volume":"10","author":"Thoo","year":"2019","journal-title":"Cell Death Dis."},{"key":"2025060509405658200_bib83","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.bbrc.2020.05.150","article-title":"Intestinal microbiota transplantation reveals the role of microbiota in dietary regulation of RegIII\u03b2 and RegIII\u03b3 expression in mouse intestine","volume":"529","author":"Udomsopagit","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025060509405658200_bib84","doi-asserted-by":"publisher","first-page":"3644","DOI":"10.4049\/jimmunol.1700087","article-title":"Filamin A regulates neutrophil adhesion, production of reactive oxygen species, and neutrophil extracellular trap release","volume":"199","author":"Uotila","year":"2017","journal-title":"J. Immunol."},{"key":"2025060509405658200_bib85","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1002\/humu.24002","article-title":"The X-linked filaminopathies: Synergistic insights from clinical and molecular analysis","volume":"41","author":"Wade","year":"2020","journal-title":"Hum. Mutat."},{"key":"2025060509405658200_bib86","doi-asserted-by":"publisher","first-page":"112424","DOI":"10.1016\/j.yexcr.2020.112424","article-title":"HPRT promotes proliferation and metastasis in head and neck squamous cell carcinoma through direct interaction with STAT3","volume":"399","author":"Wang","year":"2021","journal-title":"Exp. Cell Res."},{"key":"2025060509405658200_bib87","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003900","article-title":"TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance","volume":"10","author":"Weber","year":"2014","journal-title":"PLoS Pathog."},{"key":"2025060509405658200_bib88","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s40164-020-00197-9","article-title":"AP-1 family transcription factors: A diverse family of proteins that regulate varied cellular activities in classical hodgkin lymphoma and ALK+\u2009ALCL","volume":"10","author":"Wu","year":"2021","journal-title":"Exp. Hematol. Oncol."},{"key":"2025060509405658200_bib89","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20209620","article-title":"Probabilistic harmonization and annotation of single-cell transcriptomics data with deep generative models","volume":"17","author":"Xu","year":"2021","journal-title":"Mol. Syst. Biol."},{"key":"2025060509405658200_bib90","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s42003-018-0051-5","article-title":"Multiple claudin-claudin cis interfaces are required for tight junction strand formation and inherent flexibility","volume":"1","author":"Zhao","year":"2018","journal-title":"Commun. Biol."},{"key":"2025060509405658200_bib91","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/s41422-020-0332-7","article-title":"Interaction between microbiota and immunity in health and disease","volume":"30","author":"Zheng","year":"2020","journal-title":"Cell Res."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20240109\/1945826\/jem_20240109.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20240109\/1945826\/jem_20240109.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T09:41:09Z","timestamp":1749116469000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/222\/9\/e20240109\/278034\/Filamin-A-editing-in-myeloid-cells-reduces"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,5]]},"references-count":91,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20240109","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,5]]},"article-number":"e20240109"}}