{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:19:37Z","timestamp":1791771577874,"version":"4.3.4"},"reference-count":88,"publisher":"Rockefeller University Press","issue":"9","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.rupress.org\/terms\/"},{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI14582804"],"award-info":[{"award-number":["R01 AI14582804"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI1459604"],"award-info":[{"award-number":["R01 AI1459604"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AR074992"],"award-info":[{"award-number":["P30 AR074992"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10 RR027552"],"award-info":[{"award-number":["S10 RR027552"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AR073752"],"award-info":[{"award-number":["P30 AR073752"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK131107"],"award-info":[{"award-number":["DK131107"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA91842"],"award-info":[{"award-number":["P30 CA91842"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["INV-033564"],"award-info":[{"award-number":["INV-033564"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9,2]]},"abstract":"<jats:p>The contribution of placental immune responses to congenital Zika virus (ZIKV) syndrome remains poorly understood. Here, we leveraged a mouse model of ZIKV infection to identify mechanisms of innate immune restriction exclusively in the fetal compartment of the placenta. ZIKV principally infected mononuclear trophoblasts in the junctional zone, which was limited by mitochondrial antiviral-signaling protein (MAVS) and type I interferon (IFN) signaling mechanisms. Single nuclear RNA sequencing revealed MAVS-dependent expression of IFN-stimulated genes (ISGs) in spongiotrophoblasts but not in other placental cells that use alternate pathways to induce ISGs. ZIKV infection of Ifnar1\u2212\/\u2212 or Mavs\u2212\/\u2212 placentas was associated with greater infection of the adjacent immunocompetent decidua, and heterozygous Mavs+\/\u2212 or Ifnar1+\/\u2212 dams carrying immunodeficient fetuses sustained greater maternal viremia and tissue infection than dams carrying wild-type fetuses. Thus, MAVS-IFN signaling in the fetus restricts ZIKV infection in junctional zone trophoblasts, which modulates dissemination and outcome for both the fetus and the pregnant mother.<\/jats:p>","DOI":"10.1084\/jem.20240694","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T02:20:54Z","timestamp":1719454854000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Fetal MAVS and type I IFN signaling pathways control ZIKV infection in the placenta and maternal decidua"],"prefix":"10.1084","volume":"221","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2760-7155","authenticated-orcid":true,"given":"Yael","family":"Alippe","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04cf69335","id-type":"ROR","asserted-by":"publisher"}],"name":"Washington University School of Medicine 1 Department of Medicine, , St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6928-9893","authenticated-orcid":true,"given":"Leran","family":"Wang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04cf69335","id-type":"ROR","asserted-by":"publisher"}],"name":"Lab and Genomic Medicine, Washington University School of Medicine 2 Department of Pathology and Immunology and Center for Genome Sciences, , St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8294-3122","authenticated-orcid":true,"given":"Reyan","family":"Coskun","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04cf69335","id-type":"ROR","asserted-by":"publisher"}],"name":"Washington University School of Medicine 1 Department of Medicine, , St. Louis, MO, USA"},{"id":[{"id":"https:\/\/ror.org\/04cf69335","id-type":"ROR","asserted-by":"publisher"}],"name":"The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine 3 , St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5105-6659","authenticated-orcid":true,"given":"St\u00e9fanie P.","family":"Muraro","sequence":"additional","affiliation":[{"name":"Campinas State University, Laboratory of Emerging Viruses 4 , Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5059-0833","authenticated-orcid":true,"given":"Fang R.","family":"Zhao","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04cf69335","id-type":"ROR","asserted-by":"publisher"}],"name":"Washington University School of Medicine 1 Department of Medicine, , St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Elam-Noll","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04cf69335","id-type":"ROR","asserted-by":"publisher"}],"name":"Washington University School of Medicine 1 Department of Medicine, , St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5110-6567","authenticated-orcid":true,"given":"J. Michael","family":"White","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04cf69335","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine 5 , St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0418-2772","authenticated-orcid":true,"given":"Daiana M.","family":"Vota","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires\u2014CONICET, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales 6 , Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9536-5317","authenticated-orcid":true,"given":"Vanesa C.","family":"Hauk","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires\u2014CONICET, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales 6 , Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8304-3548","authenticated-orcid":true,"given":"Jeffrey I.","family":"Gordon","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04cf69335","id-type":"ROR","asserted-by":"publisher"}],"name":"Lab and Genomic Medicine, Washington University School of Medicine 2 Department of Pathology and Immunology and Center for Genome Sciences, , St. Louis, MO, USA"},{"id":[{"id":"https:\/\/ror.org\/04cf69335","id-type":"ROR","asserted-by":"publisher"}],"name":"The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine 3 , St. Louis, MO, USA"},{"id":[{"id":"https:\/\/ror.org\/04cf69335","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine 5 , St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2143-6570","authenticated-orcid":true,"given":"Scott A.","family":"Handley","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04cf69335","id-type":"ROR","asserted-by":"publisher"}],"name":"Lab and Genomic Medicine, Washington University School of Medicine 2 Department of Pathology and Immunology and Center for Genome Sciences, , St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8791-3165","authenticated-orcid":true,"given":"Michael S.","family":"Diamond","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04cf69335","id-type":"ROR","asserted-by":"publisher"}],"name":"Washington University School of Medicine 1 Department of Medicine, , St. Louis, MO, USA"},{"id":[{"id":"https:\/\/ror.org\/04cf69335","id-type":"ROR","asserted-by":"publisher"}],"name":"Lab and Genomic Medicine, Washington University School of Medicine 2 Department of Pathology and Immunology and Center for Genome Sciences, , St. Louis, MO, USA"},{"id":[{"id":"https:\/\/ror.org\/04cf69335","id-type":"ROR","asserted-by":"publisher"}],"name":"Washington University School of Medicine 7 Department of Molecular Microbiology, , St. Louis, MO, USA"},{"id":[{"id":"https:\/\/ror.org\/04cf69335","id-type":"ROR","asserted-by":"publisher"}],"name":"Andrew M. and Jane M. Bursky the Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine 8 , St. Louis, MO, USA"},{"id":[{"id":"https:\/\/ror.org\/04cf69335","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine 9 , St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"key":"2024072413412424100_bib1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aat6114","article-title":"Immune responses at the maternal-fetal interface","volume":"4","author":"Ander","year":"2019","journal-title":"Sci. Immunol."},{"key":"2024072413412424100_bib2","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.4049\/jimmunol.180.4.2474","article-title":"An important role for type III interferon (IFN-lambda\/IL-28) in TLR-induced antiviral activity","volume":"180","author":"Ank","year":"2008","journal-title":"J. Immunol."},{"key":"2024072413412424100_bib3","doi-asserted-by":"publisher","first-page":"783","DOI":"10.3389\/fcell.2020.00783","article-title":"Single-cell RNA-seq identifies cell subsets in human placenta that highly expresses factors driving pathogenesis of SARS-CoV-2","volume":"8","author":"Ashary","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"2024072413412424100_bib4","doi-asserted-by":"publisher","first-page":"246","DOI":"10.3390\/v11030246","article-title":"Interferon-independent upregulation of interferon-stimulated genes during human cytomegalovirus infection is dependent on IRF3 expression","volume":"11","author":"Ashley","year":"2019","journal-title":"Viruses"},{"key":"2024072413412424100_bib5","doi-asserted-by":"publisher","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"2024072413412424100_bib6","doi-asserted-by":"publisher","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: Archive for functional genomics data sets--update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"2024072413412424100_bib7","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.medj.2023.06.003","article-title":"SARS-CoV-2 niches in human placenta revealed by spatial transcriptomics","volume":"4","author":"Barrozo","year":"2023","journal-title":"Med"},{"key":"2024072413412424100_bib8","doi-asserted-by":"publisher","first-page":"251.e1","DOI":"10.1016\/j.ajog.2023.08.012","article-title":"Zika virus co-opts microRNA networks to persist in placental niches detected by spatial transcriptomics","volume":"230","author":"Barrozo","year":"2023","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2024072413412424100_bib9","doi-asserted-by":"publisher","first-page":"71.e71","DOI":"10.1016\/j.ajog.2014.07.060","article-title":"Human trophoblasts confer resistance to viruses implicated in perinatal infection","volume":"212","author":"Bayer","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2024072413412424100_bib10","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3201\/eid2303.161499","article-title":"Zika virus RNA replication and persistence in brain and placental tissue","volume":"23","author":"Bhatnagar","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"2024072413412424100_bib11","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00818-21","article-title":"Zika virus infection of pregnant Ifnar1\u2212\/\u2212 mice triggers strain-specific differences in fetal outcomes","volume":"95","author":"Bohm","year":"2021","journal-title":"J. Virol."},{"key":"2024072413412424100_bib12","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1056\/NEJMoa1602412","article-title":"Zika Virus Infection in Pregnant Women in Rio de Janeiro","volume":"375","author":"Brasil","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"2024072413412424100_bib13","doi-asserted-by":"publisher","first-page":"15D 13 11","DOI":"10.1002\/9780471729259.mc15d03s31","article-title":"Propagation, quantification, detection, and storage of West Nile virus","volume":"31","author":"Brien","year":"2013","journal-title":"Curr. Protoc. Microbiol."},{"key":"2024072413412424100_bib14","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1089\/jir.2017.0011","article-title":"Maternal-fetal transmission of Zika virus: Routes and signals for infection","volume":"37","author":"Cao","year":"2017","journal-title":"J. Interferon Cytokine Res."},{"key":"2024072413412424100_bib15","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00618-20","article-title":"Two genetic differences between closely related Zika virus strains determine pathogenic outcome in mice","volume":"94","author":"Carbaugh","year":"2020","journal-title":"J. Virol."},{"key":"2024072413412424100_bib16","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.03857-21","article-title":"Interferon lambda signals in maternal tissues to exert protective and pathogenic effects in a gestational stage-dependent manner","volume":"13","author":"Casazza","year":"2022","journal-title":"MBio"},{"key":"2024072413412424100_bib17","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1038\/s41564-024-01628-7","article-title":"Prevotella copri and microbiota members mediate the beneficial effects of a therapeutic food for malnutrition","volume":"9","author":"Chang","year":"2024","journal-title":"Nat. Microbiol."},{"key":"2024072413412424100_bib18","doi-asserted-by":"publisher","first-page":"1079961","DOI":"10.3389\/fcell.2022.1079961","article-title":"Single cell RNA sequencing research in maternal fetal interface","volume":"10","author":"Chen","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"2024072413412424100_bib19","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/nrmicro.2016.125","article-title":"Zika virus: Reigniting the TORCH","volume":"14","author":"Coyne","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"2024072413412424100_bib20","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/nature18296","article-title":"The Brazilian Zika virus strain causes birth defects in experimental models","volume":"534","author":"Cugola","year":"2016","journal-title":"Nature"},{"key":"2024072413412424100_bib21","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1128\/JVI.80.2.1032-1037.2006","article-title":"Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection","volume":"80","author":"DeFilippis","year":"2006","journal-title":"J. Virol."},{"key":"2024072413412424100_bib22","doi-asserted-by":"publisher","first-page":"12048","DOI":"10.1073\/pnas.1304718110","article-title":"Human placental trophoblasts confer viral resistance to recipient cells","volume":"110","author":"Delorme-Axford","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024072413412424100_bib23","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s00441-019-03055-1","article-title":"Placental cell death patterns exhibit differences throughout gestation in two strains of laboratory mice","volume":"378","author":"Detmar","year":"2019","journal-title":"Cell Tissue Res."},{"key":"2024072413412424100_bib24","doi-asserted-by":"publisher","first-page":"E6310","DOI":"10.1073\/pnas.1803406115","article-title":"Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease","volume":"115","author":"Ding","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024072413412424100_bib25","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1056\/NEJMoa1601824","article-title":"Zika virus infection with prolonged maternal viremia and fetal brain abnormalities","volume":"374","author":"Driggers","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"2024072413412424100_bib26","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"2024072413412424100_bib27","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1177\/01926233211042270","article-title":"Histology atlas of the developing mouse placenta","volume":"50","author":"Elmore","year":"2022","journal-title":"Toxicol. Pathol."},{"key":"2024072413412424100_bib28","doi-asserted-by":"publisher","first-page":"dev200104","DOI":"10.1242\/dev.200104","article-title":"Erythro-myeloid progenitor origin of Hofbauer cells in the early mouse placenta","volume":"149","author":"Freyer","year":"2022","journal-title":"Development"},{"key":"2024072413412424100_bib29","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.chom.2018.04.003","article-title":"An immunocompetent mouse model of Zika virus infection","volume":"23","author":"Gorman","year":"2018","journal-title":"Cell Host Microbe"},{"key":"2024072413412424100_bib30","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.chom.2016.05.009","article-title":"Zika virus targets human STAT2 to inhibit type I interferon signaling","volume":"19","author":"Grant","year":"2016","journal-title":"Cell Host Microbe"},{"key":"2024072413412424100_bib31","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.4049\/jimmunol.2000713","article-title":"Zika virus-infected decidual cells elicit a gestational age-dependent innate immune response and exaggerate trophoblast Zika permissiveness: Implication for vertical transmission","volume":"205","author":"Guzeloglu-Kayisli","year":"2020","journal-title":"J. Immunol."},{"key":"2024072413412424100_bib32","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nbt.4091","article-title":"Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors","volume":"36","author":"Haghverdi","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"2024072413412424100_bib33","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/j.cell.2018.02.001","article-title":"Mapping the mouse cell atlas by microwell-seq","volume":"172","author":"Han","year":"2018","journal-title":"Cell"},{"key":"2024072413412424100_bib34","doi-asserted-by":"publisher","first-page":"7696","DOI":"10.3390\/ijms22147696","article-title":"Identification of intercellular crosstalk between decidual cells and niche cells in mice","volume":"22","author":"He","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2024072413412424100_bib35","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41576-019-0169-4","article-title":"Mechanisms of early placental development in mouse and humans","volume":"21","author":"Hemberger","year":"2020","journal-title":"Nat. Rev. Genet."},{"key":"2024072413412424100_bib36","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/B978-0-12-394445-0.00004-7","article-title":"Anatomy of the mouse placenta throughout gestation","volume-title":"The Guide to Investigation of Mouse Pregnancy","author":"Isaac","year":"2014"},{"key":"2024072413412424100_bib37","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.chom.2017.08.012","article-title":"Gestational stage and IFN-\u03bb signaling regulate ZIKV infection in utero","volume":"22","author":"Jagger","year":"2017","journal-title":"Cell Host Microbe"},{"key":"2024072413412424100_bib38","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41421-022-00513-z","article-title":"A differentiation roadmap of murine placentation at single-cell resolution","volume":"9","author":"Jiang","year":"2023","journal-title":"Cell Discov."},{"key":"2024072413412424100_bib39","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.88461","article-title":"Zika virus productively infects primary human placenta-specific macrophages","volume":"1","author":"Jurado","year":"2016","journal-title":"JCI Insight"},{"key":"2024072413412424100_bib40","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.stem.2022.04.004","article-title":"Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens","volume":"29","author":"Karvas","year":"2022","journal-title":"Cell Stem Cell"},{"key":"2024072413412424100_bib41","doi-asserted-by":"publisher","first-page":"242","DOI":"10.15585\/mmwr.mm6509e2","article-title":"Increase in reported prevalence of microcephaly in infants born to women living in areas with confirmed Zika virus transmission during the first trimester of pregnancy: Brazil, 2015","volume":"65","author":"Kleber de Oliveira","year":"2016","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"2024072413412424100_bib42","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.15252\/embr.201642627","article-title":"Zika virus inhibits type-I interferon production and downstream signaling","volume":"17","author":"Kumar","year":"2016","journal-title":"EMBO Rep."},{"key":"2024072413412424100_bib43","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1084\/jem.20060792","article-title":"Essential role of IPS-1 in innate immune responses against RNA viruses","volume":"203","author":"Kumar","year":"2006","journal-title":"J. Exp. Med."},{"key":"2024072413412424100_bib44","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.chom.2016.03.010","article-title":"A mouse model of Zika virus pathogenesis","volume":"19","author":"Lazear","year":"2016","journal-title":"Cell Host Microbe"},{"key":"2024072413412424100_bib45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003118","article-title":"IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling","volume":"9","author":"Lazear","year":"2013","journal-title":"PLoS Pathog."},{"key":"2024072413412424100_bib46","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.immuni.2019.03.025","article-title":"Shared and distinct functions of type I and type III interferons","volume":"50","author":"Lazear","year":"2019","journal-title":"Immunity"},{"key":"2024072413412424100_bib47","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.3389\/fimmu.2018.02061","article-title":"The dual nature of type I and type II interferons","volume":"9","author":"Lee","year":"2018","journal-title":"Front. Immunol."},{"key":"2024072413412424100_bib48","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.jmb.2013.11.024","article-title":"Toll-like receptors in antiviral innate immunity","volume":"426","author":"Lester","year":"2014","journal-title":"J. Mol. Biol."},{"key":"2024072413412424100_bib49","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/s41467-021-27670-1","article-title":"Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"key":"2024072413412424100_bib50","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.chom.2018.05.022","article-title":"Inflammation-induced, STING-dependent autophagy restricts Zika virus infection in the Drosophila brain","volume":"24","author":"Liu","year":"2018","journal-title":"Cell Host Microbe"},{"key":"2024072413412424100_bib51","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.immuni.2011.05.003","article-title":"Immune signaling by RIG-I-like receptors","volume":"34","author":"Loo","year":"2011","journal-title":"Immunity"},{"key":"2024072413412424100_bib52","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.3389\/fmicb.2018.01350","article-title":"Zika virus non-structural protein 4A blocks the RLR-MAVS signaling","volume":"9","author":"Ma","year":"2018","journal-title":"Front. Microbiol."},{"key":"2024072413412424100_bib53","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.60266","article-title":"Single nuclei RNA-seq of mouse placental labyrinth development","volume":"9","author":"Marsh","year":"2020","journal-title":"Elife"},{"key":"2024072413412424100_bib54","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/j.cell.2016.05.008","article-title":"Zika virus infection during pregnancy in mice causes placental damage and fetal demise","volume":"165","author":"Miner","year":"2016","journal-title":"Cell"},{"key":"2024072413412424100_bib55","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00009-17","article-title":"Animal models of Zika virus infection, pathogenesis, and immunity","volume":"91","author":"Morrison","year":"2017","journal-title":"J. Virol."},{"key":"2024072413412424100_bib56","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1126\/science.8009221","article-title":"Functional role of type I and type II interferons in antiviral defense","volume":"264","author":"M\u00fcller","year":"1994","journal-title":"Science"},{"key":"2024072413412424100_bib57","doi-asserted-by":"publisher","first-page":"11414","DOI":"10.1038\/ncomms11414","article-title":"Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal-foetal interface during pregnancy","volume":"7","author":"Nelson","year":"2016","journal-title":"Nat. Commun."},{"key":"2024072413412424100_bib58","doi-asserted-by":"publisher","first-page":"490","DOI":"10.3201\/eid2702.200684","article-title":"Prolonged maternal Zika viremia as a marker of adverse perinatal outcomes","volume":"27","author":"Pomar","year":"2021","journal-title":"Emerg. Infect. Dis."},{"key":"2024072413412424100_bib59","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/B978-0-12-394445-0.00044-8","article-title":"Layer-enriched tissue dissection of the mouse placenta in late gestation","volume-title":"The Guide to Investigation of Mouse Pregnancy","author":"Qu","year":"2014"},{"key":"2024072413412424100_bib60","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.chom.2016.05.015","article-title":"Zika virus infects human placental macrophages","volume":"20","author":"Quicke","year":"2016","journal-title":"Cell Host Microbe"},{"key":"2024072413412424100_bib61","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.3389\/fimmu.2020.02146","article-title":"Zika induces human placental damage and inflammation","volume":"11","author":"Rabelo","year":"2020","journal-title":"Front. Immunol."},{"key":"2024072413412424100_bib62","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.4049\/jimmunol.1601824","article-title":"Cutting edge: Fetal\/placental type I IFN can affect maternal survival and fetal viral load during viral infection","volume":"198","author":"Racicot","year":"2017","journal-title":"J. Immunol."},{"key":"2024072413412424100_bib63","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1146\/annurev-virology-011720-095930","article-title":"Viperin reveals its true function","volume":"7","author":"Rivera-Serrano","year":"2020","journal-title":"Annu. Rev. Virol."},{"key":"2024072413412424100_bib64","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004517","article-title":"Zika virus infection and stillbirths: A case of hydrops fetalis, hydranencephaly and fetal demise","volume":"10","author":"Sarno","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"2024072413412424100_bib65","doi-asserted-by":"publisher","first-page":"E1587","DOI":"10.1073\/pnas.1616097114","article-title":"Vulnerability of primitive human placental trophoblast to Zika virus","volume":"114","author":"Sheridan","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024072413412424100_bib66","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ydbio.2005.05.010","article-title":"Determinants of trophoblast lineage and cell subtype specification in the mouse placenta","volume":"284","author":"Simmons","year":"2005","journal-title":"Dev. Biol."},{"key":"2024072413412424100_bib67","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.ydbio.2007.01.009","article-title":"Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta","volume":"304","author":"Simmons","year":"2007","journal-title":"Dev. Biol."},{"key":"2024072413412424100_bib68","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1186\/1471-2164-9-352","article-title":"Spatial and temporal expression of the 23 murine Prolactin\/Placental Lactogen-related genes is not associated with their position in the locus","volume":"9","author":"Simmons","year":"2008","journal-title":"BMC Genomics"},{"key":"2024072413412424100_bib69","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12613","article-title":"Zika virus infection of Hofbauer cells","volume":"77","author":"Simoni","year":"2017","journal-title":"Am. J. Reprod. Immunol."},{"key":"2024072413412424100_bib70","doi-asserted-by":"publisher","first-page":"5179","DOI":"10.4049\/jimmunol.0902264","article-title":"IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction","volume":"184","author":"Stirnweiss","year":"2010","journal-title":"J. Immunol."},{"key":"2024072413412424100_bib71","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"2024072413412424100_bib72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003541","article-title":"Innate immune sensing of flaviviruses","volume":"9","author":"Suthar","year":"2013","journal-title":"PLoS Pathog."},{"key":"2024072413412424100_bib73","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1056\/NEJMc1607580","article-title":"Prolonged Zika virus viremia during pregnancy","volume":"375","author":"Suy","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"2024072413412424100_bib74","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006994","article-title":"Zika virus infection in immunocompetent pregnant mice causes fetal damage and placental pathology in the absence of fetal infection","volume":"14","author":"Szaba","year":"2018","journal-title":"PLoS Pathog."},{"key":"2024072413412424100_bib75","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1093\/infdis\/jix552","article-title":"Zika virus replicates in proliferating cells in explants from first-trimester human placentas, potential sites for dissemination of infection","volume":"217","author":"Tabata","year":"2018","journal-title":"J. Infect. Dis."},{"key":"2024072413412424100_bib76","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.chom.2016.07.002","article-title":"Zika virus targets different primary human placental cells, suggesting two routes for vertical transmission","volume":"20","author":"Tabata","year":"2016","journal-title":"Cell Host Microbe"},{"key":"2024072413412424100_bib77","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/S0140-6736(16)00006-4","article-title":"Zika virus in Brazil and macular atrophy in a child with microcephaly","volume":"387","author":"Ventura","year":"2016","journal-title":"Lancet"},{"key":"2024072413412424100_bib78","doi-asserted-by":"publisher","first-page":"14575","DOI":"10.1038\/ncomms14575","article-title":"Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes","volume":"8","author":"Vermillion","year":"2017","journal-title":"Nat. Commun."},{"key":"2024072413412424100_bib79","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/s42003-022-03158-6","article-title":"ZIKV can infect human term placentas in the absence of maternal factors","volume":"5","author":"Villazana-Kretzer","year":"2022","journal-title":"Commun. Biol."},{"key":"2024072413412424100_bib80","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1093\/cid\/ciw589","article-title":"Viremia and clinical presentation in Nicaraguan patients infected with Zika virus, chikungunya virus, and dengue virus","volume":"63","author":"Waggoner","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"2024072413412424100_bib81","doi-asserted-by":"publisher","first-page":"5541","DOI":"10.1038\/s41467-023-41158-0","article-title":"Zika virus targets human trophoblast stem cells and prevents syncytialization in placental trophoblast organoids","volume":"14","author":"Wu","year":"2023","journal-title":"Nat. Commun."},{"key":"2024072413412424100_bib82","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.79794","article-title":"Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface","volume":"11","author":"Yang","year":"2022","journal-title":"Elife"},{"key":"2024072413412424100_bib83","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aao1680","article-title":"Type I interferons instigate fetal demise after Zika virus infection","volume":"3","author":"Yockey","year":"2018","journal-title":"Sci. Immunol."},{"key":"2024072413412424100_bib84","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1016\/j.cell.2016.08.004","article-title":"Vaginal exposure to Zika virus during pregnancy leads to fetal brain infection","volume":"166","author":"Yockey","year":"2016","journal-title":"Cell"},{"key":"2024072413412424100_bib85","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/j.cell.2016.07.020","article-title":"Structural basis of Zika virus-specific antibody protection","volume":"166","author":"Zhao","year":"2016","journal-title":"Cell"},{"key":"2024072413412424100_bib86","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.73792","article-title":"Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME","volume":"11","author":"Zhao","year":"2022","journal-title":"Elife"},{"key":"2024072413412424100_bib87","doi-asserted-by":"publisher","first-page":"112715","DOI":"10.1016\/j.yexcr.2021.112715","article-title":"Single-cell RNA-seq revealed diverse cell types in the mouse placenta at mid-gestation","volume":"405","author":"Zhou","year":"2021","journal-title":"Exp. Cell Res."},{"key":"2024072413412424100_bib88","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.chom.2018.10.008","article-title":"Cross-reactive dengue virus antibodies augment Zika virus infection of human placental macrophages","volume":"24","author":"Zimmerman","year":"2018","journal-title":"Cell Host Microbe"}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20240694\/1930932\/jem_20240694.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20240694\/1930932\/jem_20240694.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T09:46:00Z","timestamp":1721814360000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/221\/9\/e20240694\/276872\/Fetal-MAVS-and-type-I-IFN-signaling-pathways"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,23]]},"references-count":88,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9,2]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20240694","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,23]]},"article-number":"e20240694"}}