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Neutrophils\u2014key immune cells known primarily by their roles in inflammation and infection\u2014can link these two pathological conditions. Neutrophils contribute to cancer progression and cardiovascular complications through various mechanisms, including their ability to promote inflammation, thrombosis, and vascular damage by interacting with vascular endothelial cells, platelets, and other immune cells, or by forming NETs. In cancer, neutrophils contribute to a hypercoagulability state, which promotes tumor growth and metastasis, and can also lead to thrombotic events, myocardial infarction, and stroke. Cancer affects neutrophil numbers and functional properties, induces the appearance of several neutrophil subtypes, and can alter hematopoiesis. Here we summarize the links between cancer and cardiovascular disease, focusing on the role of neutrophils and cancer-elicited changes to their function in connecting these two disease states and highlighting the neutrophils\u2019 dynamic interaction with both diseases.<\/jats:p>","DOI":"10.1084\/jem.20242402","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T06:20:47Z","timestamp":1753251647000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Heart of the matter: Neutrophils, cancer, and cardiovascular disease"],"prefix":"10.1084","volume":"222","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7960-5181","authenticated-orcid":true,"given":"Saira","family":"Ambreen","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04tnbqb63","id-type":"ROR","asserted-by":"publisher"}],"name":"The Francis Crick Institute 1 Cancer Macroenvironment Lab, , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5450-8496","authenticated-orcid":true,"given":"Afshan","family":"McCarthy","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04tnbqb63","id-type":"ROR","asserted-by":"publisher"}],"name":"The Francis Crick Institute 1 Cancer Macroenvironment Lab, , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5513-555X","authenticated-orcid":true,"given":"Andr\u00e9s","family":"Hidalgo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03v76x132","id-type":"ROR","asserted-by":"publisher"}],"name":"Yale University School of Medicine 2 Vascular Biology and Therapeutics Program and Department of Immunobiology, , New Haven, CT,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1395-5477","authenticated-orcid":true,"given":"Jose M.","family":"Adrover","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04tnbqb63","id-type":"ROR","asserted-by":"publisher"}],"name":"The Francis Crick Institute 1 Cancer Macroenvironment Lab, , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"2025081109333698100_bib1","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1093\/intimm\/dxr007","article-title":"Mouse neutrophils are professional antigen-presenting cells programmed to instruct Th1 and Th17 T-cell differentiation","volume":"23","author":"Abi Abdallah","year":"2011","journal-title":"Int. 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