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Plasma kallikrein amplifies FXII activation, and its deficiency aggravated S. aureus skin infections, similarly to F12\u2212\/\u2212 mice. FXII deficiency impaired fibrin deposition in abscess walls, leading to leaky capsules and bacterial escape. Bacterial long-chain polyphosphate activated FXII, triggering fibrin formation. Deficiency in FXII substrate factor XI or FXII\/factor XI co-deficiency similarly exacerbated S. aureus infection. The data reveal a protective role for FXII-driven coagulation in host defense, urging caution in developing therapeutic strategies targeting this pathway.<\/jats:p>","DOI":"10.1084\/jem.20250049","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T02:21:39Z","timestamp":1743128499000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Factor XII\u2013driven coagulation traps bacterial infections"],"prefix":"10.1084","volume":"222","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1287-6766","authenticated-orcid":true,"given":"Katrin F.","family":"Nickel","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01zgy1s35","id-type":"ROR","asserted-by":"publisher"}],"name":"University Medical Center Hamburg-Eppendorf 1 Institute of Clinical Chemistry and Laboratory Medicine, , Hamburg,","place":["Germany"]},{"name":"Karolinska Institutet and University Hospital 2 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