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Monocyte-derived macrophages infiltrate the myenteric ganglia, contributing to excessive ENS remodeling and postinflammatory motility dysfunction. This neuroimmune axis is counterbalanced by a hypoxia-induced stress response in enteric neurons mediated by HIF1\u03b1. Enhancing the neuron-intrinsic hypoxia pathway limits ENS remodeling and preserves motility. 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