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Here, we identify na\u00efve CD8 T cell subsets with superior persistence and an enhanced capacity to generate effector and memory cells, leading to more effective protection. These functionally superior na\u00efve CD8 T cells are marked by IL-18R\u03b1, CD73, and CXCR3, and functionally less potent na\u00efve CD8 T cells can convert into these superior subsets through tonic TCR signaling. Their enhanced response to infections is driven by better survival of the progeny effector cells during the T cell expansion phase. This improved survival is mediated by increased Ly6C expression on effector cells derived from these functionally superior na\u00efve cells. Collectively, our findings reveal functional heterogeneity and plasticity among na\u00efve CD8 T cells and uncover a mechanism by which functionally superior na\u00efve subsets drive robust CD8 T cell responses, providing a previously unrecognized layer of immune regulation.<\/jats:p>","DOI":"10.1084\/jem.20252076","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T06:20:48Z","timestamp":1786515648000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Functional heterogeneity and plasticity in na\u00efve CD8 T cells drive superior effector and memory responses"],"prefix":"10.1084","volume":"223","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7138-2926","authenticated-orcid":true,"given":"Yamato","family":"Sajiki","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01hcyya48","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Inflammation and 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