{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:10:29Z","timestamp":1791857429594,"version":"4.3.4"},"reference-count":54,"publisher":"Rockefeller University Press","issue":"8","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Gabriella Giorgi-Cavaglieri Foundation"},{"DOI":"10.13039\/100008052","name":"Martin Escudero Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008052","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Machaon Foundation"}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,8,3]]},"abstract":"<jats:p>Asthma is a deadly chronic respiratory disease affecting over 300 million people. While allergen immunotherapy remains the only disease-modifying treatment, it is poorly applicable for patients with severe asthma. Here, we explored the therapeutic potential of regulatory T cells (Tregs) armed with chimeric allergen receptors\u2014named CAlleR\u2014redirected against the major allergen of birch pollen Bet v1. Four novel anti-Bet v1 antibodies were identified and used to engineer and functionally validate CAlleR. CAlleR Tregs showed specific in vitro activation and suppression and significantly reduced the airway hyperresponsiveness in birch pollen\u2013sensitized mice. Mechanistically, CAlleR Tregs migrated to the lungs and mediastinal lymph nodes, interacted with CD11c+ dendritic cells, and were activated in a Fc\u03b3R-dependent manner by cross-presenting Bet v1 stabilized with noncompetitive anti-Bet v1 antibodies. These findings unveil a novel mechanism for targeting soluble antigens and highlight the potential of CAlleR Tregs to prevent and treat severe allergies.<\/jats:p>","DOI":"10.1084\/jem.20252201","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T13:44:12Z","timestamp":1783345452000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Chimeric allergen receptor regulatory T cells suppress birch pollen allergic airway inflammation"],"prefix":"10.1084","volume":"223","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9452-6788","authenticated-orcid":true,"given":"Ana","family":"Alcaraz-Serna","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019whta54","id-type":"ROR","asserted-by":"publisher"}],"name":"Lausanne University Hospital and University of Lausanne 1 Division of Immunology and Allergy, , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1812-1626","authenticated-orcid":true,"given":"No\u00e9mie","family":"Chillier","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019whta54","id-type":"ROR","asserted-by":"publisher"}],"name":"Lausanne University Hospital and University of Lausanne 1 Division of Immunology and Allergy, , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5244-0823","authenticated-orcid":true,"given":"Aur\u00e9lien","family":"Trompette","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019whta54","id-type":"ROR","asserted-by":"publisher"}],"name":"Lausanne University Hospital (CHUV), University of Lausanne 2 Division of Pulmonary Medicine, Department of Medicine, , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3378-1785","authenticated-orcid":true,"given":"Laura","family":"Ermellino","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019whta54","id-type":"ROR","asserted-by":"publisher"}],"name":"Lausanne University Hospital and University of Lausanne 1 Division of Immunology and Allergy, , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2781-9250","authenticated-orcid":true,"given":"Rapha\u00ebl","family":"Porret","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019whta54","id-type":"ROR","asserted-by":"publisher"}],"name":"Lausanne University Hospital and University of Lausanne 1 Division of Immunology and Allergy, , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3518-0107","authenticated-orcid":true,"given":"Erica","family":"Lana","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019whta54","id-type":"ROR","asserted-by":"publisher"}],"name":"Lausanne University Hospital and University of Lausanne 1 Division of Immunology and Allergy, , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8770-1940","authenticated-orcid":true,"given":"Rebecca","family":"Cecchin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019whta54","id-type":"ROR","asserted-by":"publisher"}],"name":"Lausanne University Hospital and University of Lausanne 1 Division of Immunology and Allergy, , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5124-2906","authenticated-orcid":true,"given":"Apiha","family":"Shanmuganathan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019whta54","id-type":"ROR","asserted-by":"publisher"}],"name":"Lausanne University Hospital (CHUV), University of Lausanne 2 Division of Pulmonary Medicine, Department of Medicine, , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6490-3724","authenticated-orcid":true,"given":"Seher","family":"Guney","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019whta54","id-type":"ROR","asserted-by":"publisher"}],"name":"Lausanne University Hospital (CHUV), University of Lausanne 2 Division of Pulmonary Medicine, Department of Medicine, , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9963-7137","authenticated-orcid":true,"given":"Oscar","family":"Alfageme-Abello","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019whta54","id-type":"ROR","asserted-by":"publisher"}],"name":"Lausanne University Hospital and University of Lausanne 1 Division of Immunology and Allergy, , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6898-1201","authenticated-orcid":true,"given":"Eleonora","family":"Pace","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019whta54","id-type":"ROR","asserted-by":"publisher"}],"name":"Lausanne University Hospital and University of Lausanne 1 Division of Immunology and Allergy, , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1174-872X","authenticated-orcid":true,"given":"Antonio","family":"Mancarella","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019whta54","id-type":"ROR","asserted-by":"publisher"}],"name":"Lausanne University Hospital and University of Lausanne 1 Division of Immunology and Allergy, , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1202-7418","authenticated-orcid":true,"given":"Jeremy","family":"Campos","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019whta54","id-type":"ROR","asserted-by":"publisher"}],"name":"Lausanne University Hospital and University of Lausanne 1 Division of Immunology and Allergy, , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7538-4262","authenticated-orcid":true,"given":"Mathilde","family":"Foglierini","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019whta54","id-type":"ROR","asserted-by":"publisher"}],"name":"Lausanne University Hospital and University of Lausanne 1 Division of Immunology and Allergy, , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3585-9176","authenticated-orcid":true,"given":"Christophe","family":"von Garnier","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019whta54","id-type":"ROR","asserted-by":"publisher"}],"name":"Lausanne University Hospital (CHUV), University of Lausanne 2 Division of Pulmonary Medicine, Department of Medicine, , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9435-0110","authenticated-orcid":true,"given":"Craig","family":"Fenwick","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019whta54","id-type":"ROR","asserted-by":"publisher"}],"name":"Lausanne University Hospital and University of Lausanne 1 Division of Immunology and Allergy, , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8860-7928","authenticated-orcid":true,"given":"Laurent","family":"Perez","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019whta54","id-type":"ROR","asserted-by":"publisher"}],"name":"Lausanne University Hospital and University of Lausanne 1 Division of Immunology and Allergy, , Lausanne,","place":["Switzerland"]},{"name":"Center of Human Immunology Lausanne 3 , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0177-4134","authenticated-orcid":true,"given":"Niki","family":"Ubags","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019whta54","id-type":"ROR","asserted-by":"publisher"}],"name":"Lausanne University Hospital (CHUV), University of Lausanne 2 Division of Pulmonary Medicine, Department of Medicine, , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0513-7156","authenticated-orcid":true,"given":"Yannick D.","family":"Muller","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019whta54","id-type":"ROR","asserted-by":"publisher"}],"name":"Lausanne University Hospital and University of Lausanne 1 Division of Immunology and Allergy, , Lausanne,","place":["Switzerland"]},{"name":"Center of Human Immunology Lausanne 3 , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"2026070609435861400_bib1","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1016\/j.jaci.2013.03.002","article-title":"Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation","volume":"131","author":"Afshar","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026070609435861400_bib2","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.coi.2003.09.012","article-title":"Role of regulatory T cells in allergy and asthma","volume":"15","author":"Akbari","year":"2003","journal-title":"Curr. Opin. Immunol."},{"key":"2026070609435861400_bib3","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb9965","article-title":"Immune synapse instructs epigenomic and transcriptomic functional reprogramming in dendritic cells","volume":"7","author":"Alcaraz-Serna","year":"2021","journal-title":"Sci. Adv."},{"key":"2026070609435861400_bib4","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.cell.2015.08.021","article-title":"A distinct function of regulatory T cells in tissue protection","volume":"162","author":"Arpaia","year":"2015","journal-title":"Cell"},{"key":"2026070609435861400_bib5","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.jaci.2021.05.038","article-title":"Targeting immunodominant Bet v 1 epitopes with monoclonal antibodies prevents the birch allergic response","volume":"149","author":"Atanasio","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026070609435861400_bib6","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s12016-021-08866-1","article-title":"Improving the efficacy of regulatory T cell therapy","volume":"62","author":"Baeten","year":"2022","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"2026070609435861400_bib7","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/j.immuni.2013.10.016","article-title":"Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response","volume":"39","author":"Bailey-Bucktrout","year":"2013","journal-title":"Immunity"},{"key":"2026070609435861400_bib8","doi-asserted-by":"publisher","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"2026070609435861400_bib9","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1111\/all.13758","article-title":"Birch pollen allergy in Europe","volume":"74","author":"Biedermann","year":"2019","journal-title":"Allergy"},{"key":"2026070609435861400_bib10","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1056\/nejmra2032506","article-title":"Biologic therapies for severe asthma","volume":"386","author":"Brusselle","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"2026070609435861400_bib11","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1111\/cea.14486","article-title":"Polysensitisation is associated with more severe symptoms: The reality of patients with allergy","volume":"54","author":"Cacheiro-Llaguno","year":"2024","journal-title":"Clin. Exp. Allergy"},{"key":"2026070609435861400_bib12","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1158\/1078-0432.ccr-12-2422","article-title":"B-cell maturation antigen is a promising target for adoptive T-cell therapy of multiple myeloma","volume":"19","author":"Carpenter","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"2026070609435861400_bib13","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/nchembio.2565","article-title":"Rewiring T-cell responses to soluble factors with chimeric antigen receptors","volume":"14","author":"Chang","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"2026070609435861400_bib14","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.jaci.2010.09.034","article-title":"Allergen immunotherapy: A practice parameter third update","volume":"127","author":"Cox","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026070609435861400_bib15","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1093\/bioinformatics\/btv552","article-title":"ANARCI: Antigen receptor numbering and receptor classification","volume":"32","author":"Dunbar","year":"2016","journal-title":"Bioinformatics"},{"key":"2026070609435861400_bib16","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1107\/s0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"2026070609435861400_bib17","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1016\/j.jaci.2018.10.015","article-title":"Regulatory T-cell therapy for autoimmune and autoinflammatory diseases: The next frontier","volume":"142","author":"Esensten","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026070609435861400_bib18","doi-asserted-by":"publisher","first-page":"109814","DOI":"10.1016\/j.celrep.2021.109814","article-title":"A highly potent antibody effective against SARS-CoV-2 variants of concern","volume":"37","author":"Fenwick","year":"2021","journal-title":"Cell Rep."},{"key":"2026070609435861400_bib19","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1089\/scd.2008.0253","article-title":"Pulmonary passage is a major obstacle for intravenous stem cell delivery: The pulmonary first-pass effect","volume":"18","author":"Fischer","year":"2009","journal-title":"Stem Cells Dev."},{"key":"2026070609435861400_bib20","doi-asserted-by":"publisher","first-page":"104216","DOI":"10.1016\/j.cellimm.2020.104216","article-title":"CD4+ T cells engineered with FVIII-CAR and murine Foxp3 suppress anti-factor VIII immune responses in hemophilia a mice","volume":"358","author":"Fu","year":"2020","journal-title":"Cell Immunol"},{"key":"2026070609435861400_bib21","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1038\/nsb1296-1040","article-title":"X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy","volume":"3","author":"Gajhede","year":"1996","journal-title":"Nat. Struct. Biol."},{"key":"2026070609435861400_bib22","volume-title":"Global Strategy for Asthma Management and Prevention","author":"Global Initiative for Asthma","year":"2026"},{"key":"2026070609435861400_bib23","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1002\/pro.3235","article-title":"UCSF ChimeraX: Meeting modern challenges in visualization and analysis","volume":"27","author":"Goddard","year":"2018","journal-title":"Protein Sci."},{"key":"2026070609435861400_bib24","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1183\/2312508X.10007914","article-title":"The economic burden of respiratory diseases: COPD and asthma","volume-title":"Respiratory Epidemiology","author":"Gr\u00f8nseth","year":"2025"},{"key":"2026070609435861400_bib25","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"2026070609435861400_bib26","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/nri3582","article-title":"The function of Fc\u03b3 receptors in dendritic cells and macrophages","volume":"14","author":"Guilliams","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"2026070609435861400_bib27","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1002\/eji.200838904","article-title":"Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation","volume":"39","author":"Hoffmann","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"2026070609435861400_bib28","first-page":"1116","article-title":"An anti-CD30 chimeric receptor that mediates CD3-zeta-independent T-cell activation against Hodgkin's lymphoma cells in the presence of soluble CD30","volume":"58","author":"Hombach","year":"1998","journal-title":"Cancer Res."},{"key":"2026070609435861400_bib29","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1056\/nejmra1608969","article-title":"Severe and difficult-to-treat asthma in adults","volume":"377","author":"Israel","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"2026070609435861400_bib30","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1038\/s41590-024-01834-9","article-title":"A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice","volume":"25","author":"Jin","year":"2024","journal-title":"Nat. Immunol."},{"key":"2026070609435861400_bib31","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1084\/jem.20051166","article-title":"Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent","volume":"202","author":"Kearley","year":"2005","journal-title":"J. Exp. Med."},{"key":"2026070609435861400_bib32","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/mt.2011.256","article-title":"Redirected antitumor activity of primary human lymphocytes transduced with a fully human anti-mesothelin chimeric receptor","volume":"20","author":"Lanitis","year":"2012","journal-title":"Mol. Ther."},{"key":"2026070609435861400_bib33","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1107\/s2059798319011471","article-title":"Macromolecular structure determination using X-rays, neutrons and electrons: Recent developments in Phenix","volume":"75","author":"Liebschner","year":"2019","journal-title":"Acta Crystallogr. D Struct. Biol."},{"key":"2026070609435861400_bib34","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1146\/annurev.med.53.082901.103921","article-title":"The pathophysiology of asthma","volume":"53","author":"Maddox","year":"2002","journal-title":"Annu. Rev. Med."},{"key":"2026070609435861400_bib35","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1084\/jem.20130091","article-title":"Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4","volume":"210","author":"Mikhak","year":"2013","journal-title":"J. Exp. Med."},{"key":"2026070609435861400_bib36","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.4049\/jimmunol.149.4.1432","article-title":"IL-4 controls the selective endothelium-driven transmigration of eosinophils from allergic individuals","volume":"149","author":"Moser","year":"1992","journal-title":"J. Immunol."},{"key":"2026070609435861400_bib37","doi-asserted-by":"publisher","first-page":"686439","DOI":"10.3389\/fimmu.2021.686439","article-title":"Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance","volume":"12","author":"Muller","year":"2021","journal-title":"Front. Immunol."},{"key":"2026070609435861400_bib38","doi-asserted-by":"publisher","first-page":"639818","DOI":"10.3389\/fimmu.2021.639818","article-title":"The CD28-transmembrane domain mediates chimeric antigen receptor heterodimerization with CD28","volume":"12","author":"Muller","year":"2021","journal-title":"Front. Immunol."},{"key":"2026070609435861400_bib39","first-page":"3928","article-title":"Bypassing immunization: Optimized design of \u201cdesigner T cells\u201d against carcinoembryonic antigen (CEA)-expressing tumors, and lack of suppression by soluble CEA","volume":"5","author":"Nolan","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"2026070609435861400_bib40","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/s0140-6736(17)33311-1","article-title":"Asthma","volume":"391","author":"Papi","year":"2018","journal-title":"Lancet"},{"key":"2026070609435861400_bib41","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adr8941","article-title":"T cell receptor precision editing of regulatory T cells for celiac disease","volume":"17","author":"Porret","year":"2025","journal-title":"Sci. Transl Med."},{"key":"2026070609435861400_bib42","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/j.ymthe.2024.02.006","article-title":"Mechanical force determines chimeric antigen receptor microclustering and signaling","volume":"32","author":"Qiu","year":"2024","journal-title":"Mol. Ther."},{"key":"2026070609435861400_bib43","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/s41577-019-0232-6","article-title":"Treg cell-based therapies: Challenges and perspectives","volume":"20","author":"Raffin","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"2026070609435861400_bib44","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1111\/all.14140","article-title":"Profilin is a marker of severity in allergic respiratory diseases","volume":"75","author":"Ruiz-Hornillos","year":"2020","journal-title":"Allergy"},{"key":"2026070609435861400_bib45","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1016\/j.jprot.2011.03.021","article-title":"Proteomic analysis of the major birch allergen Bet v 1 predicts allergenicity for 15 birch species","volume":"74","author":"Schenk","year":"2011","journal-title":"J. Proteomics"},{"key":"2026070609435861400_bib46","doi-asserted-by":"publisher","first-page":"102289","DOI":"10.1016\/j.jaut.2019.05.017","article-title":"Regulatory T cells engineered with a novel insulin-specific chimeric antigen receptor as a candidate immunotherapy for type 1 diabetes","volume":"103","author":"Tenspolde","year":"2019","journal-title":"J. Autoimmun."},{"key":"2026070609435861400_bib47","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/nm1080","article-title":"An efficient method to make human monoclonal antibodies from memory B cells: Potent neutralization of SARS coronavirus","volume":"10","author":"Traggiai","year":"2004","journal-title":"Nat. Med."},{"key":"2026070609435861400_bib48","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1111\/ajt.17063","article-title":"Anti-HLA-A2-CAR Tregs prolong vascularized mouse heterotopic heart allograft survival","volume":"22","author":"Wagner","year":"2022","journal-title":"Am. J. Transpl."},{"key":"2026070609435861400_bib49","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1111\/all.13598","article-title":"Real-world benefits of allergen immunotherapy for birch pollen-associated allergic rhinitis and asthma","volume":"74","author":"Wahn","year":"2019","journal-title":"Allergy"},{"key":"2026070609435861400_bib50","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.chest.2019.10.053","article-title":"Characterization of severe asthma worldwide: Data from the international severe asthma registry","volume":"157","author":"Wang","year":"2020","journal-title":"Chest"},{"key":"2026070609435861400_bib51","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s12931-023-02475-6","article-title":"Global, regional, and national burden of asthma and its attributable risk factors from 1990 to 2019: A systematic analysis for the global burden of disease study 2019","volume":"24","author":"Wang","year":"2023","journal-title":"Respir. Res."},{"key":"2026070609435861400_bib52","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1097\/cji.0b013e31819b7c8e","article-title":"The Lewis-Y carbohydrate antigen is expressed by many human tumors and can serve as a target for genetically redirected T cells despite the presence of soluble antigen in serum","volume":"32","author":"Westwood","year":"2009","journal-title":"J. Immunother."},{"key":"2026070609435861400_bib53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040314","article-title":"Adoptive transfer of induced-Treg cells effectively attenuates murine airway allergic inflammation","volume":"7","author":"Xu","year":"2012","journal-title":"PLoS One"},{"key":"2026070609435861400_bib54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004654","article-title":"Mechanism of suppression of chromosomal instability by DNA polymerase POLQ","volume":"10","author":"Yousefzadeh","year":"2014","journal-title":"PLoS Genet."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20252201\/2037525\/jem_20252201.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20252201\/2037525\/jem_20252201.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T13:44:14Z","timestamp":1783345454000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/223\/8\/e20252201\/282788\/Chimeric-allergen-receptor-regulatory-T-cells"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,6]]},"references-count":54,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8,3]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20252201","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,6]]},"article-number":"e20252201"}}