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The cellular processes from antigen recognition to full B cell activation require a finely orchestrated series of events, involving signalling and intracellular trafficking mechanisms. Here, we describe a novel regulator of B cell receptor (BCR) endocytosis and intracellular trafficking. Multidomain trafficking protein sorting-related receptor with A-type repeats (SorLA) associates with the BCR and regulates uptake of both soluble and substrate-bound antigens. SorLA deletion results in altered BCR\u2013antigen intracellular trafficking to degradative compartments, modulating eventual antigen presentation. Crucially, this change in antigen trafficking results in a significant reduction in plasma cells and humoral responses in vivo. Given the critical importance of antigen presentation in immunity, as well as autoimmune disease and malignancy, these results identify a new cellular pathway in B cell biology with potential implications for immune regulation.<\/jats:p>","DOI":"10.1084\/jem.20252357","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T06:20:48Z","timestamp":1782454848000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["SorLA regulates B cell receptor uptake, trafficking, and B cell\u2013mediated immune responses\n                    <i>in vivo<\/i>"],"prefix":"10.1084","volume":"223","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3087-5273","authenticated-orcid":true,"given":"Melibea","family":"Berzosa","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hswnk62","id-type":"ROR","asserted-by":"publisher"}],"name":"Wellcome-Wolfson Institute for Experimental Medicine, 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