{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:51:57Z","timestamp":1757703117430},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1915,3,1]]},"abstract":"<jats:p>It has been established that specific liver poisons (chloroform, phosphorus) which cause histological changes in the liver cells, decrease the liver excretion of phenoltetrachlorphthalein.<\/jats:p>\n               <jats:p>Also vascular disturbances (Eck fistula, passive congestion) with or without histological evidence may cause a fall in the output of phthalein through the liver. Sufficient evidence has been brought forward to show that the phenoltetrachlorphthalein excretion is a valuable index concerning the functional capacity of the liver.<\/jats:p>\n               <jats:p>Ether anesthesia for a period of two hours usually causes a depression in the phthalein curve during the twenty-four hours following the anesthesia.<\/jats:p>\n               <jats:p>Paraldehyde in doses sufficient to give anesthesia and stupor for a few hours will give adefinite fall in phthalein excretion.<\/jats:p>\n               <jats:p>Chloral and urethane usually cause a decrease in phthalein output when given in considerable amounts.<\/jats:p>\n               <jats:p>Alcohol causes a drop in the phthalein curve when given in large doses sufficient to cause stupor for a few hours. The drop in phenoltetrachlorphthalein excretion is demonstrated in the twenty-four hours following administration of the drug. A drop in the phthalein curve to two-thirds or one-half of normal indicates a definite liver injury and temporary impairment of function.<\/jats:p>","DOI":"10.1084\/jem.21.3.203","type":"journal-article","created":{"date-parts":[[2004,6,17]],"date-time":"2004-06-17T22:31:16Z","timestamp":1087511476000},"page":"203-212","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["LIVER FUNCTION AS INFLUENCED BY ANESTHETICS AND NARCOTICS"],"prefix":"10.1084","volume":"21","author":[{"given":"G. H.","family":"Whipple","sequence":"first","affiliation":[{"name":"From the George Williams Hooper Foundation for Medical Research, University of California Medical School, San Francisco, and the Hunterian Laboratory of Experimental Pathology, Johns Hopkins Medical School, Baltimore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Speed","sequence":"additional","affiliation":[{"name":"From the George Williams Hooper Foundation for Medical Research, University of California Medical School, San Francisco, and the Hunterian Laboratory of Experimental Pathology, Johns Hopkins Medical School, Baltimore."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1915,3,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/21\/3\/203\/1173551\/203.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/21\/3\/203\/1173551\/203.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T11:04:26Z","timestamp":1601723066000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/21\/3\/203\/8571\/LIVER-FUNCTION-AS-INFLUENCED-BY-ANESTHETICS-AND"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1915,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1915,3,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.21.3.203","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1915,3,1]]}}}