{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T21:53:43Z","timestamp":1784152423104,"version":"3.55.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1915,5,1]]},"abstract":"<jats:p>Antidysenteric serum can be safely prepared in the horse by the method of three successive intravenous injections of living cultures or toxin with intervening rest periods of seven days.<\/jats:p>\n               <jats:p>When this method of immunization is employed, the specific antibodies responsible for agglutination and protection appear early and rise rapidly.<\/jats:p>\n               <jats:p>By inoculating alternately living dysentery bacilli belonging to the Shiga and Flexner groups a polyvalent serum of high titer may be prepared.<\/jats:p>\n               <jats:p>A polyvalent serum so produced should be suitable for the therapeutic treatment of acute bacillary dysentery, irrespective of the particular strain or strains of the dysentery bacillus causing the infection.<\/jats:p>\n               <jats:p>An effective antidysentery serum suitable for therapeutic employment in man can be prepared in the horse in about ten weeks.<\/jats:p>","DOI":"10.1084\/jem.21.5.515","type":"journal-article","created":{"date-parts":[[2004,6,17]],"date-time":"2004-06-17T22:31:16Z","timestamp":1087511476000},"page":"515-524","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["THE RAPID PRODUCTION OF ANTIDYSENTERIC SERUM"],"prefix":"10.1084","volume":"21","author":[{"given":"Simon","family":"Flexner","sequence":"first","affiliation":[{"name":"From the Laboratories of The Rockefeller Institute for Medical Research."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold L.","family":"Amoss","sequence":"additional","affiliation":[{"name":"From the Laboratories of The Rockefeller Institute for Medical Research."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1915,5,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/21\/5\/515\/1173665\/515.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/21\/5\/515\/1173665\/515.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T11:03:36Z","timestamp":1601723016000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/21\/5\/515\/8590\/THE-RAPID-PRODUCTION-OF-ANTIDYSENTERIC-SERUM"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1915,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1915,5,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.21.5.515","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1915,5,1]]}}}