{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:11:25Z","timestamp":1758280285055},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1915,10,1]]},"abstract":"<jats:p>1. The serum ferments are practically unaltered by a primary injection of foreign protein.<\/jats:p>\n               <jats:p>2. During the course of sensitization the injection of the antigen is followed by the mobilization of a non-specific protease which increases in rapidity and intensity as the maximum period of sensitization is reached.<\/jats:p>\n               <jats:p>3. Acute shock is accompanied by:<\/jats:p>\n               <jats:p>(a) The instantaneous mobilization of a large amount of non-specific protease; (b) a decrease in antiferment; (c) an increase in non-coagulable nitrogen of the serum; (d) an increase in amino-acids; (e) a primary decrease in serum proteoses.<\/jats:p>\n               <jats:p>4. Later there is a progressive increase in the non-coagulable nitrogen, in proteoses, and in serum lipase.<\/jats:p>\n               <jats:p>5. The acute intoxication is brought about by the cleavage of serum proteins (and proteoses) through the peptone stage by a non-specific protease.<\/jats:p>\n               <jats:p>6. The specific elements lie in the rapid, mobilization of this ferment and the colloidal serum changes which bring about the change in antiferment titer.<\/jats:p>","DOI":"10.1084\/jem.22.4.401","type":"journal-article","created":{"date-parts":[[2004,6,17]],"date-time":"2004-06-17T22:31:16Z","timestamp":1087511476000},"page":"401-417","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["THE MECHANISM OF ANAPHYLACTIC SHOCK"],"prefix":"10.1084","volume":"22","author":[{"given":"James W.","family":"Jobling","sequence":"first","affiliation":[{"name":"From the Department of Pathology, Medical Department, Vanderbilt University, Nashville."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Petersen","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Medical Department, Vanderbilt University, Nashville."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Eggstein","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Medical Department, Vanderbilt University, Nashville."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1915,10,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/22\/4\/401\/1173802\/401.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/22\/4\/401\/1173802\/401.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T11:05:18Z","timestamp":1601723118000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/22\/4\/401\/8631\/THE-MECHANISM-OF-ANAPHYLACTIC-SHOCK-STUDIES-ON"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1915,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1915,10,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.22.4.401","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1915,10,1]]}}}