{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T03:44:04Z","timestamp":1649130244354},"reference-count":0,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1916,11,1]]},"abstract":"<jats:p>1. The theory of the production of gall-bladder lesions in typhoid, by descending infection of the bile from the liver receives support from investigations with the common duct fistula method in the rabbit.<\/jats:p>\n               <jats:p>More bacilli appear in the bile with increased doses and more gall-bladder infections are obtained by increased doses.<\/jats:p>\n               <jats:p>More bacilli appear in the bile after mesenteric vein injection than after ear vein injection and more lesions result under the first condition.<\/jats:p>\n               <jats:p>More bacilli appear in the bile after injection of the same dose in immunized animals than in normal animals and more lesions also result in immunized animals.<\/jats:p>\n               <jats:p>In cholera and dysentery the same mechanism is suggested with the additional factor of a portal system septicemia.<\/jats:p>\n               <jats:p>2. After the appearance of microorganisms in rabbit bile, their fate is apparently largely determined by the antiseptic properties of the bile.<\/jats:p>\n               <jats:p>100 per cent infections cannot be secured by intravenous doses large enough to insure the presence of microorganisms in the bile.<\/jats:p>\n               <jats:p>Rabbit bile in vitro may be antiseptic to the microorganisms considered.<\/jats:p>\n               <jats:p>The antiseptic action is largely due to its alkalinity. It is apparently possible to protect the rabbit to some degree against gall-bladder infection by a previous injection of sodium bicarbonate.<\/jats:p>\n               <jats:p>3. Alkaline therapy is suggested in the prevention and cure of gall-bladder carriers.<\/jats:p>","DOI":"10.1084\/jem.24.5.497","type":"journal-article","created":{"date-parts":[[2004,6,17]],"date-time":"2004-06-17T23:20:47Z","timestamp":1087514447000},"page":"497-514","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["EXPERIMENTAL OBSERVATIONS ON THE PATHOGENESIS OF GALL-BLADDER INFECTIONS IN TYPHOID, CHOLERA, AND DYSENTERY"],"prefix":"10.1084","volume":"24","author":[{"given":"Henry J.","family":"Nichols","sequence":"first","affiliation":[{"name":"From the Laboratory Service of the Letterman General Hospital, U. S. Army, San Francisco."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1916,11,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/24\/5\/497\/1174244\/497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/24\/5\/497\/1174244\/497.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T11:10:47Z","timestamp":1601723447000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/24\/5\/497\/8750\/EXPERIMENTAL-OBSERVATIONS-ON-THE-PATHOGENESIS-OF"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1916,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1916,11,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.24.5.497","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1916,11,1]]}}}