{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:09:52Z","timestamp":1758280192989},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1919,4,1]]},"abstract":"<jats:p>The injection of the toxic proteose obtained from the contents of the obstructed small intestine causes a definite impairment of the eliminative function of the kidneys as shown by a decreased capacity to excrete urea, sodium chloride, and phenolsulfonephthalein.<\/jats:p>\n               <jats:p>This involvement of the renal function is similar to that shown by the preceding report (1) to accompany the intoxication of intestinal obstruction.<\/jats:p>\n               <jats:p>The observed depression of function is readily demonstrable even when large amounts of fluid and urea, dye, or salt are injected directly into the blood stream.<\/jats:p>\n               <jats:p>There is in all probability a temporary injury of the kidney cells, since the most important extrarenal factors have been largely eliminated in the above experiments.<\/jats:p>\n               <jats:p>There is no appreciable impairment of the renal function following the injection of a number of other proteose preparations from a variety of sources.<\/jats:p>\n               <jats:p>This study affords new evidence in favor of the view that the function of an organ can be profoundly disturbed for a time without any demonstrable anatomical lesions.<\/jats:p>\n               <jats:p>The repair of this type of injury promptly follows the disappearance of the intoxication and is functionally and anatomically perfect.<\/jats:p>","DOI":"10.1084\/jem.29.4.421","type":"journal-article","created":{"date-parts":[[2004,6,17]],"date-time":"2004-06-17T23:20:47Z","timestamp":1087514447000},"page":"421-444","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["II. RENAL FUNCTION INFLUENCED BY PROTEOSE INTOXICATION"],"prefix":"10.1084","volume":"29","author":[{"given":"Irvine","family":"McQuarrie","sequence":"first","affiliation":[{"name":"From The George Williams Hooper Foundation for Medical Research, University of California Medical School, San Francisco."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. H.","family":"Whipple","sequence":"additional","affiliation":[{"name":"From The George Williams Hooper Foundation for Medical Research, University of California Medical School, San Francisco."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1919,4,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/29\/4\/421\/1175157\/421.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/29\/4\/421\/1175157\/421.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T11:18:56Z","timestamp":1601723936000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/29\/4\/421\/8968\/II-RENAL-FUNCTION-INFLUENCED-BY-PROTEOSE"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1919,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1919,4,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.29.4.421","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1919,4,1]]}}}