{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:53:44Z","timestamp":1758279224338},"reference-count":0,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1927,2,1]]},"abstract":"<jats:p>The increased inhibiting action of serum with age on the growth of fibroblasts has been shown to be due to changes in both the lipoids and the proteins.<\/jats:p>\n               <jats:p>Although the serum protein is less inhibiting than the serum lipoid, the rate at which their inhibiting action augments with age is approximately the same.<\/jats:p>\n               <jats:p>The change in the serum protein with age is due to the disappearance of a small quantity of growth-stimulating substance, and also to an increase in concentration of inhibiting protein. The concentration of all protein fractions becomes larger as age advances.<\/jats:p>\n               <jats:p>The greater inhibiting action of the lipoid is associated with a higher concentration of total lipoid and lecithin, and a smaller content of cholesterol as the animal grows older.<\/jats:p>\n               <jats:p>The hypothesis is suggested that the inhibiting action of the serum is associated with its antienzymatic action.<\/jats:p>","DOI":"10.1084\/jem.45.2.305","type":"journal-article","created":{"date-parts":[[2004,6,18]],"date-time":"2004-06-18T06:19:10Z","timestamp":1087539550000},"page":"305-318","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["EFFECT OF AGE ON SERUM LIPOIDS AND PROTEINS"],"prefix":"10.1084","volume":"45","author":[{"given":"Lillian E.","family":"Baker","sequence":"first","affiliation":[{"name":"From the Laboratories of The Rockefeller Institute for Medical Research."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Carrel","sequence":"additional","affiliation":[{"name":"From the Laboratories of The Rockefeller Institute for Medical Research."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1927,2,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/45\/2\/305\/1177783\/305.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/45\/2\/305\/1177783\/305.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T12:07:27Z","timestamp":1601726847000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/45\/2\/305\/9574\/EFFECT-OF-AGE-ON-SERUM-LIPOIDS-AND-PROTEINS"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1927,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1927,2,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.45.2.305","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1927,2,1]]}}}