{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:13:21Z","timestamp":1756995201245},"reference-count":0,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1929,2,1]]},"abstract":"<jats:p>1. The type-specific carbohydrates (haptens) of Pneumococcus Types I, II and III, when isolated in protein-free form, are devoid of the property of inducing active anaphylactic sensitization in guinea pigs.<\/jats:p>\n               <jats:p>2. The bacterial carbohydrates of Pneumococcus, of which the Type II and Type III substances are nitrogen-free, produce rapid and fatal anaphylactic shock in guinea pigs passively sensitized with the precipitating serum of rabbits immunized with pneumococci of the homologous type; the reactions induced are type-specific.<\/jats:p>\n               <jats:p>3. In contrast to the positive results with immune rabbit serum, there is a complete absence of anaphylactic response to pneumococcus carbohydrate in guinea pigs passively sensitized with antipneumococcus horse serum.<\/jats:p>","DOI":"10.1084\/jem.49.2.251","type":"journal-article","created":{"date-parts":[[2004,6,18]],"date-time":"2004-06-18T06:19:10Z","timestamp":1087539550000},"page":"251-266","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["ANAPHYLAXIS WITH THE TYPE-SPECIFIC CARBOHYDRATES OF PNEUMOCOCCUS"],"prefix":"10.1084","volume":"49","author":[{"given":"Oswald T.","family":"Avery","sequence":"first","affiliation":[{"name":"From the Hospital of The Rockefeller Institute for Medical Research."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William S.","family":"Tillett","sequence":"additional","affiliation":[{"name":"From the Hospital of The Rockefeller Institute for Medical Research."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1929,2,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/49\/2\/251\/1178413\/251.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/49\/2\/251\/1178413\/251.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T12:18:05Z","timestamp":1601727485000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/49\/2\/251\/9833\/ANAPHYLAXIS-WITH-THE-TYPESPECIFIC-CARBOHYDRATES-OF"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1929,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1929,2,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.49.2.251","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1929,2,1]]}}}