{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T18:25:43Z","timestamp":1693592743419},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1929,3,1]]},"abstract":"<jats:p>From the foregoing study there are indications:<\/jats:p>\n               <jats:p>1. Of toxicity in all fresh human serum for the guinea pig; this toxicity tends to disappear after 48 hours after bleeding, and its manifestations are strikingly similar to those of the heterophilic antibody in immune rabbit serum.<\/jats:p>\n               <jats:p>2. Of an increased toxicity in the serum of antisera-treated human cases; this is usually coexistant with the production of other antibodies; it tends likewise to disappear in time after treatment; differential absorption experiments indicate that its character is heterophilic, and its manifestations differ from those of anaphylaxis in that certain circulatory effects\u2014hemorrhage and increased edema in the lungs and distension of the right heart\u2014are added to the usual findings in true anaphylactic deaths.<\/jats:p>","DOI":"10.1084\/jem.49.3.497","type":"journal-article","created":{"date-parts":[[2004,6,18]],"date-time":"2004-06-18T06:19:10Z","timestamp":1087539550000},"page":"497-506","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["THE TOXICITY OF HUMAN SERUM FOR THE GUINEA PIG"],"prefix":"10.1084","volume":"49","author":[{"given":"Susan Griffith","family":"Ramsdell","sequence":"first","affiliation":[{"name":"From the Research Institute of Cutaneous Medicine, Philadelphia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Davidsohn","sequence":"additional","affiliation":[{"name":"From the Research Institute of Cutaneous Medicine, Philadelphia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1929,3,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/49\/3\/497\/1178425\/497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/49\/3\/497\/1178425\/497.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T12:18:17Z","timestamp":1601727497000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/49\/3\/497\/9845\/THE-TOXICITY-OF-HUMAN-SERUM-FOR-THE-GUINEA-PIG"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1929,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1929,3,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.49.3.497","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1929,3,1]]}}}