{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T22:02:50Z","timestamp":1698876170544},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1929,10,1]]},"abstract":"<jats:p>It has been demonstrated that many multiples of minimal doses of Bacillus typhosus reacting factors can be neutralized by specific immune sera.<\/jats:p>\n               <jats:p>The potency of a given serum can be conveniently titrated against increasing amounts of reacting factors.<\/jats:p>\n               <jats:p>If the immune serum is diluted or if the amount of the reacting factors is too large for a given amount of serum, there is obtained neutralization but only irregularly.<\/jats:p>\n               <jats:p>Normal and heterologous sera (therapeutic meningococcus and erysipelas horse sera) free of normal agglutinins or possessing normal agglutinins of a low titer (1:16) for Bacillus typhosus are not able to neutralize the reacting factors. There is obtained questionable neutralization with a serum possessing normal Bacillus typhosus agglutinins in dilution 1:64.<\/jats:p>\n               <jats:p>The titer of the neutralizing antibodies increases in the course of immunization.<\/jats:p>\n               <jats:p>Immune sera exercise a definite protection against the mortality induced by intravenous injection of Bacillus typhosus culture filtrates.<\/jats:p>","DOI":"10.1084\/jem.50.4.513","type":"journal-article","created":{"date-parts":[[2004,6,18]],"date-time":"2004-06-18T06:19:10Z","timestamp":1087539550000},"page":"513-520","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["STUDIES ON BACILLUS TYPHOSUS TOXIC SUBSTANCES"],"prefix":"10.1084","volume":"50","author":[{"given":"Gregory","family":"Shwartzman","sequence":"first","affiliation":[{"name":"From the Laboratories of the Mount Sinai Hospital, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1929,10,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/50\/4\/513\/1178808\/513.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/50\/4\/513\/1178808\/513.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T12:25:15Z","timestamp":1601727915000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/50\/4\/513\/9923\/STUDIES-ON-BACILLUS-TYPHOSUS-TOXIC-SUBSTANCES-III"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1929,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1929,10,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.50.4.513","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1929,10,1]]}}}