{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:45:46Z","timestamp":1792665946092,"version":"4.5.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1929,10,1]]},"abstract":"<jats:p>It has been demonstrated that many multiples of minimal doses of Bacillus typhosus reacting factors can be neutralized by specific immune sera.<\/jats:p>\n               <jats:p>The potency of a given serum can be conveniently titrated against increasing amounts of reacting factors.<\/jats:p>\n               <jats:p>If the immune serum is diluted or if the amount of the reacting factors is too large for a given amount of serum, there is obtained neutralization but only irregularly.<\/jats:p>\n               <jats:p>Normal and heterologous sera (therapeutic meningococcus and erysipelas horse sera) free of normal agglutinins or possessing normal agglutinins of a low titer (1:16) for Bacillus typhosus are not able to neutralize the reacting factors. There is obtained questionable neutralization with a serum possessing normal Bacillus typhosus agglutinins in dilution 1:64.<\/jats:p>\n               <jats:p>The titer of the neutralizing antibodies increases in the course of immunization.<\/jats:p>\n               <jats:p>Immune sera exercise a definite protection against the mortality induced by intravenous injection of Bacillus typhosus culture filtrates.<\/jats:p>","DOI":"10.1084\/jem.50.4.521","type":"journal-article","created":{"date-parts":[[2004,6,18]],"date-time":"2004-06-18T06:19:10Z","timestamp":1087539550000},"page":"521-531","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":172,"title":["CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS"],"prefix":"10.1084","volume":"50","author":[{"given":"Walther F.","family":"Goebel","sequence":"first","affiliation":[{"name":"From the Hospital of The Rockefeller Institute for Medical Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oswald T.","family":"Avery","sequence":"additional","affiliation":[{"name":"From the Hospital of The Rockefeller Institute for Medical Research"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1929,10,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/50\/4\/521\/1178670\/521.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/50\/4\/521\/1178670\/521.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T12:22:31Z","timestamp":1601727751000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/50\/4\/521\/9928\/CHEMOIMMUNOLOGICAL-STUDIES-ON-CONJUGATED"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1929,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1929,10,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.50.4.521","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1929,10,1]]}}}