{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:25:36Z","timestamp":1756995936232},"reference-count":0,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1929,11,1]]},"abstract":"<jats:p>1. Guinea pigs passively sensitized with the serum of rabbits immunized with an artificially prepared sugar-protein (gluco-globulin) exhibit typical anaphylactic shock when subsequently inoculated with gluco-albumin; the serum of rabbits immunized with a second synthetic sugar-protein (galacto-globulin) similarly sensitizes guinea pigs to galacto-albumin. The reactions, in each instance, are specific and depend for their specificity on the carbohydrate component, and not on the protein fraction of the synthesized sugar-protein.<\/jats:p>\n               <jats:p>2. Guinea pigs actively sensitized with gluco-globulin or galacto-globulin are similarly subject to anaphylactic shock, when injected, after 21 days, with sugar-proteins containing carbohydrate identical with that present in the sensitizing antigen, regardless of the kind of protein with which it is combined.<\/jats:p>\n               <jats:p>3. The unconjugated glucosides, although themselves not capable of inducing shock, inhibit the anaphylactic reaction when injected immediately prior to the introduction of the toxigenic sugar-protein. The protective action of the glucosides disappears within two hours after injection. In order to elicit the phenomenon, the carbohydrate must be the same as that combined in the sugar-protein complex.<\/jats:p>\n               <jats:p>4. Anaphylactic shock may be induced by uncombined globulin in guinea pigs passively sensitized with either antigluco-globulin serum or antigalacto-globulin serum; globulin is similarly effective in animals actively sensitized with gluco-globulin or galacto-globulin. The reactions elicited by globulin alone are dependent upon the common protein present in the antigens, and exhibit only species specificity.<\/jats:p>","DOI":"10.1084\/jem.50.5.551","type":"journal-article","created":{"date-parts":[[2004,6,18]],"date-time":"2004-06-18T06:19:10Z","timestamp":1087539550000},"page":"551-567","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS"],"prefix":"10.1084","volume":"50","author":[{"given":"William S.","family":"Tillett","sequence":"first","affiliation":[{"name":"From the Hospital of The Rockefeller Institute for Medical Research"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oswald T.","family":"Avery","sequence":"additional","affiliation":[{"name":"From the Hospital of The Rockefeller Institute for Medical Research"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walther F.","family":"Goebel","sequence":"additional","affiliation":[{"name":"From the Hospital of The Rockefeller Institute for Medical Research"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1929,11,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/50\/5\/551\/1140159\/551.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/50\/5\/551\/1140159\/551.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T08:15:25Z","timestamp":1601712925000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/50\/5\/551\/9945\/CHEMOIMMUNOLOGICAL-STUDIES-ON-CONJUGATED"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1929,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1929,11,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.50.5.551","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1929,11,1]]}}}