{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:03:08Z","timestamp":1758279788013},"reference-count":0,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1932,12,1]]},"abstract":"<jats:p>1. A comparative study has been made of the cellular reactions induced by phosphatides from five strains of acid-fast bacilli. Each of these reactions is characterized principally by epithelioid cells and giant cells.<\/jats:p>\n               <jats:p>2. The phosphatides are first phagocytized by young connective tissue cells or monocytes. The lipoid is then dispersed into fine particles with the formation of classical epithelioid cells.<\/jats:p>\n               <jats:p>3. A comparison has been made of the reactions induced by heat-killed and defatted tubercle bacilli with those induced by tuberculophosphatide.<\/jats:p>\n               <jats:p>4. Further studies have been made to determine whether or not the phosphatide causes sensitization to tuberculin. It does not do so.<\/jats:p>\n               <jats:p>5. The life cycle of the epithelioid cell has been observed in all its stages.<\/jats:p>","DOI":"10.1084\/jem.56.6.867","type":"journal-article","created":{"date-parts":[[2004,6,18]],"date-time":"2004-06-18T06:19:10Z","timestamp":1087539550000},"page":"867-891","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["THE CELLULAR REACTIONS TO LIPOID FRACTIONS FROM ACID-FAST BACILLI"],"prefix":"10.1084","volume":"56","author":[{"given":"Kenneth C.","family":"Smithburn","sequence":"first","affiliation":[{"name":"From the Laboratories of The Rockefeller Institute for Medical Research"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence R.","family":"Sabin","sequence":"additional","affiliation":[{"name":"From the Laboratories of The Rockefeller Institute for Medical Research"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1932,12,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/56\/6\/867\/1140379\/867.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/56\/6\/867\/1140379\/867.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T08:17:36Z","timestamp":1601713056000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/56\/6\/867\/3171\/THE-CELLULAR-REACTIONS-TO-LIPOID-FRACTIONS-FROM"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1932,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1932,12,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.56.6.867","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1932,12,1]]}}}