{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T15:27:14Z","timestamp":1652110034835},"reference-count":0,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1933,8,1]]},"abstract":"<jats:p>Titrations were made of yellow fever virus in stegomyia mosquitoes, using rhesus monkeys as test animals. It was found that:<\/jats:p>\n               <jats:p>(a) The average mosquito immediately after engorging on highly infectious blood contained between 1 and 2 million lethal doses of virus. The titer of freshly ingested blood was as high as 1 billion lethal doses of virus per cubic centimeter.<\/jats:p>\n               <jats:p>(b) During the fortnight succeeding a meal on infectious blood there occurred a reduction of titratable virus to not more than 1 per cent of that present in the freshly fed insects.<\/jats:p>\n               <jats:p>(c) The titer was somewhat higher at later periods. This rise in titer signified possibly not a multiplication, but merely an increase of extracellular virus and of that easily freed by grinding to a titratable form.<\/jats:p>\n               <jats:p>(d) At no later stage did the quantity of titratable virus equal that demonstrable in freshly fed insects.<\/jats:p>","DOI":"10.1084\/jem.58.2.211","type":"journal-article","created":{"date-parts":[[2004,6,18]],"date-time":"2004-06-18T06:19:10Z","timestamp":1087539550000},"page":"211-226","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["THE TITRATION OF YELLOW FEVER VIRUS IN STEGOMYIA MOSQUITOES"],"prefix":"10.1084","volume":"58","author":[{"given":"Nelson C.","family":"Davis","sequence":"first","affiliation":[{"name":"From the Yellow Fever Laboratory of the International Health Division of the Rockefeller Foundation at Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Martin","family":"Frobisher","sequence":"additional","affiliation":[{"name":"From the Yellow Fever Laboratory of the International Health Division of the Rockefeller Foundation at Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wray","family":"Lloyd","sequence":"additional","affiliation":[{"name":"From the Yellow Fever Laboratory of the International Health Division of the Rockefeller Foundation at Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1933,8,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/58\/2\/211\/1179905\/211.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/58\/2\/211\/1179905\/211.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T12:47:17Z","timestamp":1601729237000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/58\/2\/211\/3219\/THE-TITRATION-OF-YELLOW-FEVER-VIRUS-IN-STEGOMYIA"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1933,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1933,8,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.58.2.211","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1933,8,1]]}}}