{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:53:58Z","timestamp":1758279238418},"reference-count":0,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1934,1,1]]},"abstract":"<jats:p>Adult dogs maintained on an artificial, balanced ration adequate in all dietary essentials as far as is known except water-soluble, heat-stable vitamin B2 (G) developed, after a sufficient time, a slowly progressive disease characterized by loss of weight, persistent vomiting and diarrhea, and marked muscular weakness, which ended fatally in from 200 to over 300 days.<\/jats:p>\n               <jats:p>The clinical features of this condition, as pointed out in the discussion, are quite different from those characterizing the canine disease known as black tongue.<\/jats:p>\n               <jats:p>The anatomic changes in this condition consist of marked demyelination of the peripheral nerves, including the vagus; degeneration of the medullary sheaths and replacement by gliosis of the posterior columns of the spinal cord, particularly the fasciculi graciles; degeneration of the medullary sheaths of the posterior and less often of the anterior nerve roots of the cord; occasionally slight degenerative changes in most of the other fiber tracts of the cord.<\/jats:p>\n               <jats:p>Attention is called to the fact that degenerative lesions in the central nervous system similar or identical with these have frequently been described in pellagra in man.<\/jats:p>","DOI":"10.1084\/jem.59.1.21","type":"journal-article","created":{"date-parts":[[2004,6,18]],"date-time":"2004-06-18T06:19:10Z","timestamp":1087539550000},"page":"21-34","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["STUDIES ON THE NERVOUS SYSTEM IN DEFICIENCY DISEASES"],"prefix":"10.1084","volume":"59","author":[{"given":"H. M.","family":"Zimmerman","sequence":"first","affiliation":[{"name":"From the Departments of Pathology and Physiological Chemistry, Yale University School of Medicine, New Haven"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethel","family":"Burack","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Physiological Chemistry, Yale University School of Medicine, New Haven"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1934,1,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/59\/1\/21\/1180027\/21.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/59\/1\/21\/1180027\/21.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T12:47:13Z","timestamp":1601729233000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/59\/1\/21\/3255\/STUDIES-ON-THE-NERVOUS-SYSTEM-IN-DEFICIENCY"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1934,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1934,1,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.59.1.21","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1934,1,1]]}}}