{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T08:36:01Z","timestamp":1698482161971},"reference-count":0,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1935,8,1]]},"abstract":"<jats:p>The observations presented in this paper may be summarized as follows:<\/jats:p>\n               <jats:p>A study has been made on an isolated group of children with heart disease.<\/jats:p>\n               <jats:p>All of these individuals, with one exception, were rheumatic subjects.<\/jats:p>\n               <jats:p>Many of them carried a strain of hemolytic streptococcus in the throat flora during the winter of 1934. The organism produced no detectible toxin and was not associated with respiratory disease.<\/jats:p>\n               <jats:p>Four patients contracted chicken pox during the winter months. None developed rheumatic recrudescences.<\/jats:p>\n               <jats:p>All of the individuals were in good health on March 1.<\/jats:p>\n               <jats:p>A severe epidemic of influenza began on March 22. All but six children contracted the disease. The filterable virus responsible for this outbreak was recovered.<\/jats:p>\n               <jats:p>This agent did not activate the rheumatic process. It was followed by an outbreak of streptococcus infection and appeared to facilitate its spread.<\/jats:p>\n               <jats:p>The source of these infections was not traced. They were due to a single type of hemolytic streptococcus which was a strong toxin producer. Its cultural, biochemical and serological characteristics were different from those of the carrier strain.<\/jats:p>\n               <jats:p>Of seventeen individuals proven bacteriologically to be infected with the epidemic strain, fourteen rheumatic subjects developed acute rheumatism, two rheumatic subjects and one patient with congenital heart disease escaped.<\/jats:p>\n               <jats:p>These fourteen rheumatic attacks were accompanied by a rise in antistreptolysin titer coincident with the onset of symptoms.<\/jats:p>\n               <jats:p>In four of these attacks it was possible to exclude influenza as a causative factor.<\/jats:p>\n               <jats:p>The clinical observations, the bacteriological findings and the immunological evidence indicate that this severe outbreak of rheumatic fever was caused by Streptococcus hemolyticus, which appeared to be a single strain by type.<\/jats:p>","DOI":"10.1084\/jem.62.2.137","type":"journal-article","created":{"date-parts":[[2004,6,18]],"date-time":"2004-06-18T06:19:10Z","timestamp":1087539550000},"page":"137-158","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["STUDIES ON THE IMMUNE RESPONSE OF THE RHEUMATIC SUBJECT AND ITS RELATIONSHIP TO ACTIVITY OF THE RHEUMATIC PROCESS"],"prefix":"10.1084","volume":"62","author":[{"given":"Alvin F.","family":"Coburn","sequence":"first","affiliation":[{"name":"From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth H.","family":"Pauli","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1935,8,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/62\/2\/137\/1180519\/137.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/62\/2\/137\/1180519\/137.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T12:55:30Z","timestamp":1601729730000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/62\/2\/137\/4042\/STUDIES-ON-THE-IMMUNE-RESPONSE-OF-THE-RHEUMATIC"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1935,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1935,8,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.62.2.137","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1935,8,1]]}}}