{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:02:30Z","timestamp":1757703750332},"reference-count":0,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1937,5,1]]},"abstract":"<jats:p>1. The infectious agent of trachoma can be freed from extraneous bacteria by passage through rabbit testicle.<\/jats:p>\n               <jats:p>2. The infectious agent multiplies little, if at all, during such passage, but in many instances retains its infectivity undiminished.<\/jats:p>\n               <jats:p>3. No specific changes occur in the rabbit testicle incidentally to the passage.<\/jats:p>\n               <jats:p>4. On rare occasion the trachoma agent may be freed from bacteria by intracerebral passage. The brain tissues show no specific reaction.<\/jats:p>\n               <jats:p>5. Filtration experiments with Seitz, Kramer, Berkefeld, and Elford filters confirm the general observation that the infectious agent is filterable with difficulty.<\/jats:p>\n               <jats:p>6. Tissue culture experiments, with tissues containing the infectious agent (conjunctiva, rabbit testicle, brain, etc.), conducted under a wide variety of conditions, proved uniformly unsuccessful in the cultivation of the agent.<\/jats:p>\n               <jats:p>7. The agent is inactivated by bile, AgNO3, phenol, cocaine, tartar emetic, and gentian violet. Its heat inactivation temperature is between 45\u00b0 and 50\u00b0C., at a time interval of 15 minutes.<\/jats:p>\n               <jats:p>8. Attempts to preserve the infectious agent in glycerine were unsuccessful.<\/jats:p>\n               <jats:p>9. The accumulated evidence suggests that the infectious agent of trachoma is a virus.<\/jats:p>","DOI":"10.1084\/jem.65.5.735","type":"journal-article","created":{"date-parts":[[2004,6,21]],"date-time":"2004-06-21T23:43:35Z","timestamp":1087861415000},"page":"735-755","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["THE PROBABLE NATURE OF THE INFECTIOUS AGENT OF TRACHOMA"],"prefix":"10.1084","volume":"65","author":[{"given":"L. A.","family":"Julianelle","sequence":"first","affiliation":[{"name":"From the Oscar Johnson Institute, Washington University School of Medicine, St. Louis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. W.","family":"Harrison","sequence":"additional","affiliation":[{"name":"From the Oscar Johnson Institute, Washington University School of Medicine, St. Louis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Morris","sequence":"additional","affiliation":[{"name":"From the Oscar Johnson Institute, Washington University School of Medicine, St. Louis"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1937,5,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/65\/5\/735\/1180994\/735.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/65\/5\/735\/1180994\/735.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T13:04:17Z","timestamp":1601730257000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/65\/5\/735\/3597\/THE-PROBABLE-NATURE-OF-THE-INFECTIOUS-AGENT-OF"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1937,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1937,5,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.65.5.735","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1937,5,1]]}}}