{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T15:38:44Z","timestamp":1649000324398},"reference-count":0,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1938,8,1]]},"abstract":"<jats:p>Vaccination of susceptible mice with St. Louis encephalitis virus induced an acquired immunity to intracerebral inoculation which appeared within 1 week. When first demonstrable this immunity was at a very high level and it remained so for about 6 weeks, after which time it declined and disappeared completely between the 12th and 20th week after vaccination.<\/jats:p>\n               <jats:p>Humoral antibodies of significant titre could not be demonstrated during the first 6 weeks after vaccination when actual immunity to intracerebral inoculation was at its highest level. Antibodies were first detected 8 weeks after vaccination, when immunity was decreasing. The humoral antibody titre reached its peak at 23 weeks, at which time immunity had completely disappeared. A high level of circulating antibody was still present 37 weeks after vaccination.<\/jats:p>\n               <jats:p>The evidence presented leads to the conclusion that humoral antibodies do not play a major part in the immunity acquired by susceptible mice after vaccination against St. Louis encephalitis virus.<\/jats:p>","DOI":"10.1084\/jem.68.2.263","type":"journal-article","created":{"date-parts":[[2004,6,21]],"date-time":"2004-06-21T23:43:35Z","timestamp":1087861415000},"page":"263-271","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["RELATION BETWEEN DEGREE OF IMMUNITY OF MICE FOLLOWING VACCINATION WITH ST. LOUIS ENCEPHALITIS VIRUS AND THE TITRE OF THE PROTECTIVE ANTIBODIES OF THE SERUM"],"prefix":"10.1084","volume":"68","author":[{"given":"H. L.","family":"Hodes","sequence":"first","affiliation":[{"name":"From the Laboratories of The Rockefeller Institute for Medical Research"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. T.","family":"Webster","sequence":"additional","affiliation":[{"name":"From the Laboratories of The Rockefeller Institute for Medical Research"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1938,8,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/68\/2\/263\/1140857\/263.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/68\/2\/263\/1140857\/263.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T08:22:35Z","timestamp":1601713355000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/68\/2\/263\/4210\/RELATION-BETWEEN-DEGREE-OF-IMMUNITY-OF-MICE"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1938,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1938,8,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.68.2.263","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1938,8,1]]}}}