{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T07:25:47Z","timestamp":1772609147505,"version":"3.50.1"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1940,7,1]]},"abstract":"<jats:p>The experimental rations commonly used in studies on the vitamin B2 complex are, as a rule, low in content of choline.<\/jats:p>\n               <jats:p>Addition of vitamin B6 has an aggravating influence on the specific effect of deficiency of choline, especially with regard to the development of cortical necrosis of the kidneys.<\/jats:p>\n               <jats:p>The acute and subacute lesions associated with this specific type of renal injury are described.<\/jats:p>\n               <jats:p>The renal lesions and fat infiltration of the liver, observed in rats kept on a vitamin B free diet, supplemented with thiamine, riboflavin and vitamin B6, are indistinguishable from those attributed hitherto to cystine intoxication.<\/jats:p>\n               <jats:p>Attention is drawn to the ro\u0302le of choline as a potential member of the vitamin B2 complex and, in this connection, to the importance of the ratio cystine\/methionine in the diet.<\/jats:p>","DOI":"10.1084\/jem.72.1.1","type":"journal-article","created":{"date-parts":[[2004,6,21]],"date-time":"2004-06-21T23:43:35Z","timestamp":1087861415000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["CHOLINE AS A MEMBER OF THE VITAMIN B2 COMPLEX"],"prefix":"10.1084","volume":"72","author":[{"given":"Paul","family":"Gyo\u0308rgy","sequence":"first","affiliation":[{"name":"From the Babies and Childrens Hospital, the Institute of Pathology, and the Departments of Pediatrics and Pathology, School of Medicine, Western Reserve University, Cleveland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Goldblatt","sequence":"additional","affiliation":[{"name":"From the Babies and Childrens Hospital, the Institute of Pathology, and the Departments of Pediatrics and Pathology, School of Medicine, Western Reserve University, Cleveland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1940,7,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/72\/1\/1\/1181883\/1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/72\/1\/1\/1181883\/1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T13:17:34Z","timestamp":1601731054000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/72\/1\/1\/4421\/CHOLINE-AS-A-MEMBER-OF-THE-VITAMIN-B2-COMPLEX"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1940,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1940,7,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.72.1.1","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1940,7,1]]}}}