{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:47:14Z","timestamp":1758278834182},"reference-count":0,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1941,12,1]]},"abstract":"<jats:p>1. Highly purified scarlet fever toxin has been prepared from culture filtrates of two scarlatinal strains (NY5 and 594B) of hemolytic streptococcus grown on a medium of defined composition.<\/jats:p>\n               <jats:p>2. The flocculation reaction of Rane and Wyman has been studied quantitatively and has been shown specific for scarlet fever toxin and antitoxin.<\/jats:p>\n               <jats:p>3. Scarlet fever toxin from strains NY5 and 594B are quantitatively identical in their immunological behavior.<\/jats:p>\n               <jats:p>4. Pure scarlet fever toxin contains 0.00023 mg. nitrogen per flocculating unit and close to 1.3 x 108 skin test doses per mg. nitrogen as calculated from the immunological data. Both the immunological and the analytical data suggest that scarlet fever toxin is a protein. Similar calculations indicate that scarlet fever antitoxin contains 0.00093 mg. nitrogen per unit.<\/jats:p>\n               <jats:p>5. The scarlet fever toxin-antitoxin complex is readily dissociated in dilute solutions. In this respect the scarlet fever toxin-antitoxin system contrasts sharply with the diphtheria toxin-antitoxin system.<\/jats:p>\n               <jats:p>6. The scarlet fever toxin-antitoxin reaction is discussed in relation to other flocculation reactions.<\/jats:p>","DOI":"10.1084\/jem.74.6.545","type":"journal-article","created":{"date-parts":[[2004,6,21]],"date-time":"2004-06-21T23:43:35Z","timestamp":1087861415000},"page":"545-556","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["A QUANTITATIVE STUDY OF THE SCARLET FEVER TOXIN-ANTITOXIN FLOCCULATION REACTION"],"prefix":"10.1084","volume":"74","author":[{"given":"George A.","family":"Hottle","sequence":"first","affiliation":[{"name":"From the Department of Bacteriology, School of Medicine, University of Pennsylvania, Philadephia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"A. M.","family":"Pappenheimer","sequence":"additional","affiliation":[{"name":"From the Department of Bacteriology, School of Medicine, University of Pennsylvania, Philadephia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1941,12,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/74\/6\/545\/1182293\/545.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/74\/6\/545\/1182293\/545.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T13:32:04Z","timestamp":1601731924000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/74\/6\/545\/4570\/A-QUANTITATIVE-STUDY-OF-THE-SCARLET-FEVER"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1941,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1941,12,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.74.6.545","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1941,12,1]]}}}